Ultrastructural immunolocalization of the atrial natriuretic factor pathways in fetal, neonatal, and adult Syrian hamsters: from the atrial cardiomyocytes to the circulation via the endocardium, atrial capillaries and epicardium.
Creator
Gilloteaux J; Jennes L; Menu R; Vanderhaeghen J J
Publisher
Journal of submicroscopic cytology and pathology
Date
1991
1991-01
Description
Atrial natriuretic factor (ANF)-immunoreactivity was identified with peroxidase-antiperoxidase staining and immunoelectron microscopic gold labeling techniques in atrial tissues of fetal, newborn and adult Syrian hamsters.
Focal ellipsoid deposits in the atrial myocytes of Syrian hamster.
Creator
Gilloteaux J; Jennes L; Stoeckel M E; Vanderhaeghen J J
Publisher
Ultrastructural pathology
Date
1994
1994-04
Description
A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been speculated eventually to contain atrial natriuretic factor (ANF). The present study demonstrated that they are fibrillar in nature, however, and do not contain ANF-immunoreactive product. Because their morphologic aspect is analogous to that described in human heart and in the pathology of other contractile tissues, it is suggested that they probably consist of intermediate filaments and/or associated macromolecules.