1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2146/ajhp100225" target="_blank" rel="noreferrer noopener">http://doi.org/10.2146/ajhp100225</a>
Pages
519–521
Issue
6
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability of extemporaneously prepared oxandrolone oral suspensions.
Publisher
An entity responsible for making the resource available
American Journal of Health-System Pharmacy
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-03-15
Subject
The topic of the resource
Human; Descriptive Statistics; Administration; Oral; Drug Compounding; Suspensions; Acid-Base Equilibrium; Androgens – Administration and Dosage; Weight Gain – Chemically Induced
Creator
An entity primarily responsible for making the resource
Johnson Cary E; Cober Mary Petrea; Hawkins Katherine A; Julian Justin D
Description
An account of the resource
Purpose. The stability of extemporaneously prepared oxandrolone oral suspensions was studied. Methods. Oxandrolone oral suspension (1 mg/mL) was prepared using oxandrolone tablets, Ora-Plus, and either Ora-Sweet or Ora-Sweet SF. Three identical samples of each formulation were prepared and stored in 2-oz amber plastic bottles with child-resistant caps at room temperature (23-25 °C). After thorough but gentle shaking by hand to prevent foaming, a 1-mL sample was withdrawn from each of the six bottles, diluted with mobile phase to an expected concentration of 200 µg/mL, and assayed in duplicate by injecting 5 µL into the high-performance liquid chromatography system immediately after preparation and at 7, 14, 35, 60, and 90 days. The samples were examined for any change in color or pH on each day of analysis. The stability of the suspensions was determined by calculating the percentage of the initial oxandrolone concentration remaining on each test day. Stability was defined as the retention of at least 90% of the initial oxandrolone concentration. Results. At least 98% of the original oxandrolone concentration remained in both formulations at the end of the 90-day study period. There was no appreciable change in odor, taste, color, or pH. Both suspensions remained white in color and sweet with no aftertaste throughout the study period. The oxandrolone was easily resuspended with gentle shaking. Conclusion. Extemporaneously prepared suspensions of oxandrolone 1 mg/mL in 1:1 mixtures of Ora-Plus and either Ora-Sweet or Ora-Sweet SF were stable for at least 90 days when stored in 2-oz amber plastic bottles at room temperature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2146/ajhp100225" target="_blank" rel="noreferrer noopener">10.2146/ajhp100225</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Acid-Base Equilibrium
Administration
American Journal of Health-System Pharmacy
Androgens – Administration and Dosage
Cober Mary Petrea
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Descriptive Statistics
Drug Compounding
Hawkins Katherine A
Human
Johnson Cary E
Julian Justin D
NEOMED College of Pharmacy
Oral
Suspensions
Weight Gain – Chemically Induced
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2146/ajhp100274" target="_blank" rel="noreferrer noopener">http://doi.org/10.2146/ajhp100274</a>
Pages
420–423
Issue
5
Volume
68
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability of an extemporaneous alcohol-free melatonin suspension.
Publisher
An entity responsible for making the resource available
American Journal of Health-System Pharmacy
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011
Subject
The topic of the resource
Drug Stability; Descriptive Statistics; Administration; Oral; Drug Compounding; Melatonin; Suspensions; Taste
Creator
An entity primarily responsible for making the resource
Johnson Cary E; Cober Mary Petrea; Thome Tennille; Rouse Emily
Description
An account of the resource
Purpose. The stability of alcohol-free oral suspensions of melatonin 1 mg/mL, extemporaneously prepared from two commercially available melatonin tablet products, was studied. Methods. Four 1-mg/mL melatonin suspensions were prepared. Formulations A and B contained 20 crushed 3-mg tablets of melatonin combined with a 1:1 mixture of Ora-Plus and either Ora-Sweet or Ora-Sweet SF to produce a volume of 60 mL. Formulations C and D were prepared by crushing 20 combination tablets containing melatonin 3 mg and pyridoxine hydrochloride 10 mg and then combining the powder with a 1:1 mixture of Ora-Plus and either Ora-Sweet or Ora-Sweet SF to produce a 60-mL volume. The suspensions were prepared in triplicate and stored at room temperature in amber plastic prescription bottles. Immediately after preparation and on days 7, 15, 30, 60, and 90, the samples were assayed in duplicate by stability-indicating high-performance liquid chromatography (HPLC). The samples were also evaluated for any changes in color, odor, and taste. Results. HPLC analysis demonstrated that at least 94% of the initial melatonin concentration in formulations A and B, and at least 98% of that in formulations C and D, remained throughout the 90-day study period. Detectable changes in color, odor, or taste occurred in all of the formulations. Conclusion. Extemporaneously prepared, alcohol-free, 1-mg/mL suspensions of melatonin and melatonin-pyridoxine hydrochloride in a 1:1 mixture of Ora- Plus and either Ora Sweet or Ora Sweet SF were stable for at least 90 days when stored in 2-oz amber plastic bottles at room temperature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2146/ajhp100274" target="_blank" rel="noreferrer noopener">10.2146/ajhp100274</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Administration
American Journal of Health-System Pharmacy
Cober Mary Petrea
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Descriptive Statistics
Drug Compounding
Drug Stability
Johnson Cary E
Melatonin
NEOMED College of Pharmacy
Oral
Rouse Emily
Suspensions
Taste
Thome Tennille