1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1111/joim.13244" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/joim.13244</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). ISSN 1365-2796 0954-6820 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1111/joim.13244" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1111/joim.13244</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number February 2021 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Family & Community Medicine Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Practical Recommendations for Timely, Accurate Diagnosis of Symptomatic Alzheimer's Disease (MCI and Dementia) in Primary Care: A Review and Synthesis. Date A point or period of time associated with an event in the lifecycle of the resource 2021 2021-01-18 Subject The topic of the resource Alzheimer Disease; Biomarkers; Dementia; Disease-Modifying Therapies; Mild Cognitive Impairment; Primary Health Care Creator An entity primarily responsible for making the resource Liss JL;Seleri MAS;Cummings J;Atri A;Geldmacher DS;Candela SF;Devanand DP;Fillit HM;Susman J;Mintzer J;Bittner T;Brunton SA;Kerwin DR;Clay JW;Small GW;Grossberg GT;Clevenger CK;Cotter V;Stefanacci R;Wise-Brown A;Sabbagh MN Description An account of the resource The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention, diagnosis and management must evolve as new treatment paradigms and disease-modifying therapies (DMTs) emerge. Our understanding of AD has grown substantially: No longer conceptualized as a late-in-life syndrome of cognitive and functional impairments, we now recognize that AD pathology builds silently for decades before cognitive impairment is detectable. Clinically, AD first manifests subtly as mild cognitive impairment (MCI) due to AD before progressing to dementia. Emerging optimism for improved outcomes in AD stem from a focus on preventive interventions in mid-life and timely, biomarker-confirmed diagnosis at early signs of cognitive deficits (ie, MCI due to AD and mild AD dementia). A timely AD diagnosis is particularly important for optimizing patient care and enabling the appropriate use of anticipated DMTs. An accelerating challenge for PCCs and AD specialists will be to respond to innovations in diagnostics and therapy for AD in a system that is not currently well positioned to do so. To overcome these challenges, PCCs and AD specialists must collaborate closely to navigate and optimize dynamically evolving AD care in the face of new opportunities. In the spirit of this collaboration, we summarize here some prominent and influential models that inform our current understanding of AD. We also advocate for timely and accurate (ie, biomarker-defined) diagnosis of early AD. In doing so, we consider evolving issues related to prevention, detecting emerging cognitive impairment, and the role of biomarkers in the clinic. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1111/joim.13244" target="_blank" rel="noreferrer noopener">10.1111/joim.13244</a> Format The file format, physical medium, or dimensions of the resource journalArticle Publisher An entity responsible for making the resource available Journal Of Internal Medicine 2021 Alzheimer disease Atri A Biomarkers Bittner T Brunton SA Candela SF Clay JW Clevenger CK Cotter V Cummings J dementia Department of Family & Community Medicine Devanand DP Disease-Modifying Therapies February 2021 List Fillit HM Geldmacher DS Grossberg GT Journal Of Internal Medicine journalArticle Kerwin DR Liss JL Mild Cognitive Impairment Mintzer J NEOMED College of Medicine Primary Health Care Sabbagh MN Seleri MAS Small GW Stefanacci R Susman J Wise-Brown A