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Text
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URL Address
<a href="http://doi.org/10.1016/j.jddst.2017.09.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jddst.2017.09.007</a>
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Pages
436-443
Volume
41
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Title
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In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles
Publisher
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Journal of Drug Delivery Science and Technology
Date
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2017
2017-10
Subject
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cancer; cellular uptake; copolymer micelles; Drug; drug-delivery; Folate; nanoparticles; nanoparticles; Pharmacokinetics; Pharmacology & Pharmacy; polymeric micelles; targeted delivery; targeting; Tissue distribution
Creator
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Hong W X; Hu R F; Huang X C; Lu X Q; Czech T; Tang J H
Description
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Folate is widely used as a target ligand for tumor cells, and poly (L-aspartic acid)-b-poly-(L-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect, folate-conjugated PAA-PPA micelles were synthesized. To evaluate the hypothesis, we assessed the pharmacokinetics and biodistribution of.a new antitumor drug 4-amino-2-trifluoromethyl-phenyl retinate (ATPR) loaded into the micelles. We also observed in vivo imaging of 1,1'-dioctadecy1-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) loaded micelles to confirm distribution. The results showed that ATPR-loaded, folate-modified PAA-PPA displayed a prolonged circulation half-life and iinproved the targeting effect. (C) 2017 Elsevier B.V. All tights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.jddst.2017.09.007" target="_blank" rel="noreferrer noopener">10.1016/j.jddst.2017.09.007</a>
Format
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Journal Article or Conference Abstract Publication
2017
Cancer
cellular uptake
copolymer micelles
Czech T
Drug
drug-delivery
Folate
Hong W X
Hu R F
Huang X C
Journal Article or Conference Abstract Publication
Journal of Drug Delivery Science and Technology
Lu X Q
Nanoparticles
pharmacokinetics
Pharmacology & Pharmacy
polymeric micelles
Tang J H
targeted delivery
Targeting
Tissue Distribution