1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1002/jez.b.22990" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jez.b.22990</a> ISSN 1552-5015 1552-5007 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1002/jez.b.22990" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/jez.b.22990</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number August 2020 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology NEOMED Postdoc Publications Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (balaena mysticetus). Publisher An entity responsible for making the resource available Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution Date A point or period of time associated with an event in the lifecycle of the resource 2020 2020-07-29 Subject The topic of the resource aging; Cetacea; bone; whales; osteoblasts; hyperostosis Creator An entity primarily responsible for making the resource Cooper LN; Ball HC; Vinyard CJ; Safadi FF; George JC; Thewissen JGM Description An account of the resource Bowhead whales are among the longest-lived mammals with an extreme lifespan of about 211 years. During the first 25 years of their lives, rib bones increase in mineral density and the medulla transitions from compact to trabecular bone. Molecular drivers associated with these phenotypic changes in bone remain unknown. This study assessed expression levels of osteogenic genes from samples of rib bones of bowheads. Samples were harvested from prenatal to 86-year-old whales, representing the first third of the bowhead lifespan. Fetal to 2-year-old bowheads showed expression levels consistent with the rapid deposition of the bone extracellular matrix. Sexually mature animals showed expression levels associated with low rates of osteogenesis and increased osteoclastogenesis. After the first 25 years of life, declines in osteogenesis corresponded with increased expression of EZH2, an epigenetic regulator of osteogenesis. These findings suggest EZH2 may be at least one epigenetic modifier that contributes to the age-related changes in the rib bone phenotype along with the transition from compact to trabecular bone. Ancient cetaceans and their fossil relatives also display these phenotypes, suggesting EZH2 may have shaped the skeleton of whales in evolutionary history. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1002/jez.b.22990" target="_blank" rel="noreferrer noopener">10.1002/jez.b.22990</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2020 Aging August 2020 List Ball HC Bone Cetacea Cooper LN Department of Anatomy & Neurobiology George JC Hyperostosis Journal of Experimental Zoology. Part B Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution journalArticle Molecular and Developmental Evolution NEOMED College of Medicine NEOMED College of Medicine Postdoc NEOMED Postdoc Publications Osteoblasts Safadi FF Thewissen JGM Vinyard CJ WHALES