1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2012.04.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2012.04.009</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
178-187
Issue
1
Volume
24
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis
Publisher
An entity responsible for making the resource available
Journal of Nutritional Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
Biochemistry & Molecular Biology; cancer chemoprevention; Chemoprevention; cyclooxygenase-2; cyclooxygenase-2; factor-kappa-b; gene-expression; heat-shock proteins; hepatocarcinogenesis; human-disease; Inflammation; inhibitors; molecular chaperones; nitric-oxide synthase; Nuclear factor-kappaB; Nutrition & Dietetics; oxidative stress; Pomegranate; punica-granatum l.
Creator
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Bishayee A; Thoppil R J; Darvesh A S; Ohanyan V; Meszaros J G; Bhatia D
Description
An account of the resource
Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation. Due to dismal prognosis and limited therapeutic intervention, chemoprevention has emerged as a viable approach to reduce the morbidity and mortality of HCC. Pomegranate fruit is a rich source of phytochemicals endowed with potent antioxidant and anti-inflammatory properties. We previously reported that pomegranate phytochemicals inhibit diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats though nuclear factor E2-related factor 2 (Nrf2)-mediated antioxidant mechanisms. Since Nrf2 also acts as a key mediator of the nuclear factor-kappaB (NF-kappa B)-regulated inflammatory pathway, our present study investigated the anti-inflammatory mechanisms of a pomegranate emulsion (PE) during DENA-induced rat hepatocarcinogenesis. Rats were administered with PE (1 or 10 g/kg) 4 weeks before and 18 weeks following DENA initiation. There was a significant increase in hepatic expressions of inducible nitric oxide synthase, 3-nitrotyrosine, heat shock protein 70 and 90, cyclooxygenase-2 and NF-kappa B in DENA-exposed rat livers. PE dose-dependently suppressed all aforementioned elevated inflammatory markers. A conspicuous finding of this study involves lack of cardiotoxicity of PE as assessed by monitoring cardiac function using noninvasive echocardiography. Our results provide substantial evidence that suppression of the inflammatory cascade through modulation of NF-kappa B signaling pathway may represent a novel mechanism of liver tumor inhibitory effects of PE against experimental hepatocarcinogenesis. Data presented here coupled with those of our earlier study underline the importance of simultaneously targeting two interconnected molecular circuits, namely, Nrf2-mediated redox signaling and NF-kappa B-regulated inflammatory pathway, by pomegranate phytoconstituents to achieve chemoprevention of HCC. (C) 2013 Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jnutbio.2012.04.009" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2012.04.009</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Bhatia D
Biochemistry & Molecular Biology
Bishayee A
cancer chemoprevention
Chemoprevention
cyclooxygenase-2
Darvesh A S
Department of Pharmaceutical Sciences
factor-kappa-b
gene-expression
Heat-Shock Proteins
Hepatocarcinogenesis
human-disease
Inflammation
inhibitors
Journal Article or Conference Abstract Publication
Journal of Nutritional Biochemistry
Meszaros J G
molecular chaperones
NEOMED College of Pharmacy
nitric-oxide synthase
Nuclear factor-kappaB
Nutrition & Dietetics
Ohanyan V
Oxidative Stress
Pomegranate
punica-granatum l.
Thoppil R J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2012.04.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2012.04.009</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
178-187
Issue
1
Volume
24
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis
Publisher
An entity responsible for making the resource available
Journal of Nutritional Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
Biochemistry & Molecular Biology; cancer chemoprevention; chemoprevention; cyclooxygenase-2; cyclooxygenase-2; factor-kappa-b; gene-expression; heat-shock proteins; hepatocarcinogenesis; human-disease; inflammation; inhibitors; molecular chaperones; nitric-oxide synthase; Nuclear factor-kappaB; Nutrition & Dietetics; oxidative stress; Pomegranate; punica-granatum l.
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Darvesh A S; Ohanyan V; Meszaros J G; Bhatia D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jnutbio.2012.04.009" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2012.04.009</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Bhatia D
Biochemistry & Molecular Biology
Bishayee A
cancer chemoprevention
Chemoprevention
cyclooxygenase-2
Darvesh A S
Department of Pharmaceutical Sciences
factor-kappa-b
gene-expression
Heat-Shock Proteins
Hepatocarcinogenesis
human-disease
Inflammation
inhibitors
Journal of Nutritional Biochemistry
Meszaros J G
molecular chaperones
NEOMED College of Pharmacy
nitric-oxide synthase
Nuclear factor-kappaB
Nutrition & Dietetics
Ohanyan V
Oxidative Stress
Pomegranate
punica-granatum l.
Thoppil R J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2010.09.001</a>
Pages
1035–1046
Issue
11
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Publisher
An entity responsible for making the resource available
Journal of Nutritional Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Male; Animals; Rats; Chemoprevention; Phenobarbital; Plants; Biochemical Phenomena; Nitrosamines; Preventive Cardiovascular Nurses Association; Proteins – Metabolism; Cell Physiology – Drug Effects; Liver Neoplasms – Metabolism; Liver Neoplasms – Pathology; Antineoplastic Agents – Therapeutic Use; Liver Neoplasms – Prevention and Control; Liver – Pathology; Plant Extracts – Therapeutic Use; Apoptosis – Drug Effects; Liver Neoplasms – Chemically Induced
Creator
An entity primarily responsible for making the resource
Bishayee A; Mbimba T; Thoppil R J; Háznagy-Radnai E; Sipos P; Darvesh A S; Folkesson H G; Hohmann J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2010.09.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Antineoplastic Agents – Therapeutic Use
Apoptosis – Drug Effects
Biochemical Phenomena
Bishayee A
Cell Physiology – Drug Effects
Chemoprevention
Darvesh A S
Department of Pharmaceutical Sciences
Folkesson H G
Háznagy-Radnai E
Hohmann J
Journal of Nutritional Biochemistry
Liver – Pathology
Liver Neoplasms – Chemically Induced
Liver Neoplasms – Metabolism
Liver Neoplasms – Pathology
Liver Neoplasms – Prevention and Control
Male
Mbimba T
NEOMED College of Pharmacy
Nitrosamines
Phenobarbital
Plant Extracts – Therapeutic Use
Plants
Preventive Cardiovascular Nurses Association
Proteins – Metabolism
Rats
Sipos P
Thoppil R J