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40
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Text
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URL Address
<a href="http://doi.org/10.4103/1477-3163.51368" target="_blank" rel="noreferrer noopener">http://doi.org/10.4103/1477-3163.51368</a>
Pages
9–9
Volume
8
Dublin Core
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Title
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d -Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis.
Publisher
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Journal of carcinogenesis
Date
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2009
1905-07
Creator
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Rabi Thangaiyan; Bishayee Anupam
Description
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BACKGROUND: Clinical trials have shown that docetaxel combined with other novel agents can improve the survival of androgen-independent prostate cancer patients. d -Limonene, a non-nutrient dietary component, has been found to inhibit various cancer cell growths without toxicity. We sought to characterize whether a non-toxic dose of d -limonene may enhance tumor response to docetaxel in an in vitro model of metastatic prostate cancer. MATERIALS AND METHODS: Human prostate carcinoma DU-145 and normal prostate epithelial PZ-HPV-7 cells were treated with various concentrations of d -limonene, docetaxel or a combination of both, and cell viability was determined by MTT assay. Intracellular reactive oxygen species (ROS), reduced glutathione (GSH) and caspase activity were measured. Apoptosis and apoptosis-related proteins were studied by enzyme-linked immunosorbent assay and Western blotting, respectively. RESULTS: d -Limonene and docetaxel in combination significantly enhanced the cytotoxicity to DU-145 cells than PZ-HPV-7 cells. Exposure of DU-145 cells to a combined d -limonene and docetaxel resulted in higher ROS generation, depletion of GSH, accompanied by increased caspase activity than docetaxel alone. It also triggered a series of effects involving cytochrome c , cleavages of caspase-9, 3 and poly (ADP-ribose) polymerase, and a shift in Bad:Bcl-xL ratio in favor of apoptosis. Apoptotic effect was significantly blocked on pretreatment with N -acetylcystein, indicating that antitumor effect is initiated by ROS generation, and caspase cascades contribute to the cell death. CONCLUSION: Our results show, for the first time, that d -limonene enhanced the antitumor effect of docetaxel against prostate cancer cells without being toxic to normal prostate epithelial cells. The combined beneficial effect could be through the modulation of proteins involved in mitochondrial pathway of apoptosis. d -Limonene could be used as a potent non-toxic agent to improve the treatment outcome of hormone-refractory prostate cancer with docetaxel.
Identifier
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<a href="http://doi.org/10.4103/1477-3163.51368" target="_blank" rel="noreferrer noopener">10.4103/1477-3163.51368</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Bishayee Anupam
Journal of carcinogenesis
Rabi Thangaiyan
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4103/1477-3163.67074" target="_blank" rel="noreferrer noopener">http://doi.org/10.4103/1477-3163.67074</a>
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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MicroRNAs and lung cancer: Biology and applications in diagnosis and prognosis.
Publisher
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Journal of carcinogenesis
Date
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2010
2010-08
Subject
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gene expression; lung cancer; Carcinogenesis; microRNA
Creator
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Mallick Reema; Patnaik Santosh Kumar; Yendamuri Sai
Description
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MicroRNAs are tiny non-coding RNA molecules which play important roles in the epigenetic control of cellular processes by preventing the translation of proteins from messenger RNAs (mRNAs). A single microRNA can target different mRNAs, and an mRNA can be targeted by multiple microRNAs. Such complex interplays underlie many molecular pathways in cells, and specific roles for many microRNAs in physiological as well as pathological phenomena have been identified. Changes in expression of microRNAs have been associated with a wide variety of disease conditions, and microRNA-based biomarkers are being developed for the identification and monitoring of such states. This review provides a general overview of the current state of knowledge about the biology of microRNAs, and specific information about microRNAs with regard to the diagnosis and prognosis of lung cancer.
Identifier
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<a href="http://doi.org/10.4103/1477-3163.67074" target="_blank" rel="noreferrer noopener">10.4103/1477-3163.67074</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Carcinogenesis
Gene Expression
Journal of carcinogenesis
Lung cancer
Mallick Reema
MicroRNA
Patnaik Santosh Kumar
Yendamuri Sai