Browse Items (35 total)
- Tags: Journal of lipid research
Fluorocholesterols, In Contrast To Hydroxycholesterols, Exhibit Interfacial Properties Similar To Cholesterol
Tags: 2000, A, bile-acids, Biochemistry & Molecular Biology, Carey M C, condensation, enzyme-catalyzed oxidation, isotherm, Journal Article or Conference Abstract Publication, Journal of lipid research, Kauffman J M, monolayers, Orientation, orphan nuclear receptor, phosphatidylcholine, phosphatidylcholines, reductase-activity, side-chain, spectroscopic imaging, sterol synthesis, surface balance, surface potential, Westerman P W
Cholesterol 7-alpha-hydroxylase - Evidence For Transcriptional Regulation By Cholesterol Or Metabolic Products Of Cholesterol In The Rat
Tags: 1993, bile fistula, bile-acid synthesis, Biochemistry & Molecular Biology, biosynthesis, Chiang J Y L, Cloning, enterohepatic circulation, enzyme, hepatic cholesterol, hepatocytes, Heuman D M, HMG-CoA reductase, Hylemon P B, Jones M P, Journal Article or Conference Abstract Publication, Journal of lipid research, liver microsomes, lovastatin, messenger-rna, mevalonate, Pandak W M, Stimulation, Vlahcevic Z R
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Tags: 2013, apolipoprotein-b secretion, Bi L P, Biochemistry & Molecular Biology, Cells, Chiang J Y L, Diabetes, Ding W X, Dunn W, extracellular signal-regulated kinase, Fatty Liver, Function, induced insulin-resistance, Journal Article or Conference Abstract Publication, Journal of lipid research, LDL, Li T G, Lipid Metabolism, Liver, mitogen-activated protein kinase, Obesity, overproduction, Oxidative Stress, Roberts B, ubiquitination, Vascular, vldl production
Peroxisome Proliferator-activated Receptor Alpha (ppar Alpha) And Agonist Inhibit Cholesterol 7 Alpha-hydroxylase Gene (cyp7a1) Transcription
Tags: 2000, bezafibrate, Bile acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, cytochrome P450, Drugs, elements, expression, fatty-acids, gallstones, HNF-4, hypolipidemic, hypolipidemic drugs, isoform, Journal of lipid research, lipoprotein metabolism, Marrapodi M, Nuclear Receptors, peroxisome proliferators, rat, suppression
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Tags: 2013, apolipoprotein-b secretion, Bi L P, Biochemistry & Molecular Biology, Cells, Chiang J Y L, Diabetes, Ding W X, Dunn W, extracellular signal-regulated kinase, Fatty Liver, Function, induced insulin-resistance, Journal of lipid research, LDL, Li T G, Lipid Metabolism, Liver, mitogen-activated protein kinase, Obesity, overproduction, Oxidative Stress, Roberts B, ubiquitination, Vascular, vldl production
Transcriptional activation of the cholesterol 7 alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors
Tags: 1998, alpha-hydroxylase, bile acid response element, Bile acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, cholesterol 7, Crestani M, cytochrome P450, elements, expression, factor coup-tf, Galli G, gene transcription and regulation, hormone receptor, Journal Article or Conference Abstract Publication, Journal of lipid research, Liver, messenger-rna, Metabolism, mutations, nuclear, promoter, rat, retinoic acid receptors, Sadeghpour A, Stroup D
Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Tags: 1, 2014, 25-dihydroxyvitamin d-3, Absorption, BILE acids, bile-acid, Biochemistry & Molecular Biology, Cheng J, Chiang J Y L, cytochrome-p450 3a4, Disease, expression, Fang Z Z, Gonzalez F J, Journal Article or Conference Abstract Publication, Journal of lipid research, Kim J H, Krausz K W, Metabolomics, Permeability, Tanaka N, vitamin D receptor
Nuclear receptor-mediated repression of human cholesterol 7 alpha-hydroxylase gene transcription by bile acids
Tags: 2001, activation, Bile acid synthesis, Biochemistry & Molecular Biology, Chen W L, Chiang J Y L, cyp7a, cytochrome P450, expression, hepg2 cells, identification, Journal Article or Conference Abstract Publication, Journal of lipid research, Liver, mechanism of gene regulation, messenger-rna, orphan receptor, Owsley E, promoter, SHP, Stroup D, Yang Y Z
Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1
Tags: 1999, 27-hydroxycholesterol, 7-alpha-hydroxylase, bile-acid synthesis, Biochemistry & Molecular Biology, Brain, Chiang J Y L, Cholesterol, cholesterol 7 alpha-hydroxylase, cytochrome P450, dehydroepiandrosterone (DHEA), human liver-microsomes, identification, Javitt N B, Journal Article, Journal of lipid research, Martin K O, neurosteroids, Transcription, Wu Z L
Physicochemical characterization of a model digestive mixture by H-2 NMR
Tags: 1995, adult human-beings, bile salts, bile-salt, biliary lipid systems, Biochemistry & Molecular Biology, c-13 nmr, Cholesterol, contents, digestion, fat, H-2-labeled lipids, human intestinal, intestinal lipids, Journal Article, Journal of lipid research, liquid-crystalline phases, nuclear magnetic-resonance, phosphatidylcholine mixed micelles, physical-chemical behavior, Westerman P W
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7 alpha-hydroxylase gene (CYP7A1)
Tags: 2000, BILE acids, bile-acid synthesis, Biochemistry & Molecular Biology, Chiang J Y L, chicken ovalbumin, cholesterol metabolism, dna-binding, Hepatocyte Nuclear Factor 4, hormone-receptor superfamily, Journal Article, Journal of lipid research, messenger-rna, orphan receptors, promoter, Receptors, Response Elements, retinoic acid, Stroup D, thyroid-hormone, transcriptional regulation, upstream promoter transcription factor II
Hormonal regulation of cholesterol 7 alpha-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat
Tags: 1997, bile-acid biosynthesis, Biochemistry & Molecular Biology, Chiang J Y L, Cholesterol, cholesterol 7 alpha-hydroxylase, cultures, gene, gene cyp7, Glucocorticoid, hepatic cholesterol, hepatocyte cultures, Heuman D M, Hylemon P B, Journal Article, Journal of lipid research, Liver, messenger-rna levels, monolayer-cultures, Pandak W M, primary, protein-kinase-c, Redford K, regulation, sterol 27-hydroxylase, Stravitz R T, thyroid, thyroid-hormone, Vlahcevic Z R
BILE-ACID SYNTHESIS .6. REGULATION OF CHOLESTEROL 7-ALPHA-HYDROXYLASE BY TAUROCHOLATE AND MEVALONATE
Tags: 1992, 3-hydroxy-3-methylglutaryl, 7-alpha-hydroxylase, BILE acids, Biochemistry & Molecular Biology, biosynthesis, Chiang J Y L, circadian-rhythm, Cloning, coenzyme, enzyme, hepatocytes, Heuman D M, HMG-CoA reductase, Hylemon P B, Journal Article, Journal of lipid research, Liver, messenger-rna, Pandak W M, rat-liver microsomes, reductase, substrate, Vlahcevic Z R
The stimulatory effect of LXR alpha is blocked by SHP despite the presence of a LXR alpha binding site in the rabbit CYP7A1 promoter
Tags: 2006, alpha-fetoprotein transcription, bile-acid biosynthesis, Biochemistry & Molecular Biology, Chiang J Y L, cholesterol 7 alpha-hydroxylase, cholesterol 7-alpha-hydroxylase gene, dietary-cholesterol, factor, Farnesoid X receptor, inhibition, Journal Article, Journal of lipid research, liver X receptor, messenger-rna levels, Nuclear Receptor, orphan, Pan L X, rat, Salen G, Saumoy M, Shang Q, SHP, taurocholate, Tint G S, Transcription, Xu G R
Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
Tags: 2011, Anakk S, beta-oxidation, Biochemistry & Molecular Biology, birth-weight, Choi J S, diet-induced obesity, fatty-acid oxidation, hepatic steatosis, Induced, insulin sensitivity, insulin-resistance, Jang H C, Journal Article, Journal of lipid research, Kim J, Kim S C, Lee J M, Lee K U, Lee Y K, lipid-metabolism, Liver, Moore D D, negative feedback-regulation, Novak C M, Oxygen Consumption, Park J, Park Y J, quotient, respiratory, retinoic acid, signaling pathways, skeletal-muscle, Tseng H T, Yechoor V
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.
Tags: 1999, Animals, Base Sequence, Blotting, Cell Line, Chiang J Y, Chromosome Mapping, Cloning, Codon, Complementary/biosynthesis/*isolation & purification, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA, Genetic, Genetic/genetics, Humans, Hydroxycholesterols/metabolism, Initiator, Javitt N B, Journal of lipid research, Luciferases/genetics, Martin K O, Mice, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Nucleic Acid, Promoter Regions, Regulatory Sequences, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Wu Z
Physicochemical characterization of a model digestive mixture by 2H NMR.
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
Tags: *Promoter Regions, *Transcription, *Transcription Factors, 1996, Base Sequence, Binding Sites, Cell Line, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Consensus Sequence, Crestani M, Department of Integrative Medical Sciences, DNA-Binding Proteins/genetics/metabolism, Enzyme Repression, Enzymologic/*drug effects, Galli G, Gene Expression Regulation, Genes, Genetic, Glucocorticoid/genetics/metabolism, Glucocorticoids/pharmacology, Hepatocyte Nuclear Factor 3-alpha, Humans, Insulin/pharmacology, Journal of lipid research, Marrapodi M, Molecular Sequence Data, NEOMED College of Medicine, Nuclear Proteins/genetics/metabolism, Phorbol Esters/pharmacology, Receptors, Recombinant Fusion Proteins/biosynthesis, Reporter, Stroup D, Thyroid Hormones/pharmacology, Transfection, Wang D P
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Tags: *Receptors, *Transcription, 2000, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Cultured, Department of Integrative Medical Sciences, DNA Primers, DNA-Binding Proteins/*metabolism, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Luciferases/genetics, Mutation, NEOMED College of Medicine, Phosphoproteins/*metabolism, Promoter Regions, Rats, Recombinant Proteins/metabolism, Reporter, Sprague-Dawley, Steroid, Stroup D, Transcription Factors/*metabolism, Tumor Cells
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Expression and purification of human cholesterol 7 alpha-hydroxylase in Escherichia coli.
Tags: 1994, Animals, Base Sequence, Catalysis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/genetics/*isolation & purification, Cytochrome P-450 Enzyme System/biosynthesis/isolation & purification, Department of Integrative Medical Sciences, Escherichia coli, Humans, Immunochemistry, Journal of lipid research, Karam W G, Kinetics, Molecular Sequence Data, NEOMED College of Medicine, Rats, Recombinant Proteins/biosynthesis, Solubility, Subcellular Fractions/enzymology
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: *Promoter Regions, *Transcription, 1995, Animals, Base Sequence, Cell Count, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cultured, Cyclic AMP/pharmacology, Department of Integrative Medical Sciences, Enzymologic/*physiology, Gene Expression Regulation, Genetic, Hormones/*pharmacology, Journal of lipid research, Luciferases/genetics, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Phorbol Esters/pharmacology, Rats, Second Messenger Systems/physiology, Stroup D, Transfection, Tumor Cells
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y
Bile acids: regulation of synthesis.
Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Tags: *Gene Expression Regulation, 2008, Animals, Cell Line, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic, Forkhead Transcription Factors/physiology, Humans, Insulin/*physiology, Journal of lipid research, Li Tiangang, Ma Huiyan, Male, NEOMED College of Medicine, Nerve Tissue Proteins/physiology, Rats, Signal Transduction, Smad3 Protein/antagonists & inhibitors/pharmacology, Sprague-Dawley, Transforming Growth Factor beta1/*physiology, Tumor, Tumor Necrosis Factor-alpha/*physiology
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Tags: *Lipid Metabolism, 2007, ATP Binding Cassette Transporter, ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters/genetics, Base Sequence, Cell Line, Chen Wenling, Chiang John Y L, Cholestanetriol 26-Monooxygenase/*metabolism, Cholesterol, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Fluorinated, Genes, Genetic/drug effects, Genetic/genetics, HDL/metabolism, Hepatocytes/drug effects/enzymology/metabolism, Humans, Hydrocarbons, Hydroxycholesterols/metabolism/pharmacology, Intestinal Mucosa/metabolism, Intestines/cytology/drug effects/enzymology, Journal of lipid research, Li Tiangang, Member 1, Messenger/genetics/metabolism, Molecular Sequence Data, NEOMED College of Medicine, Pregnane X Receptor, Promoter Regions, Receptors, Reporter, Response Elements/genetics, Rifampin/pharmacology, RNA, Steroid/*metabolism, Subfamily G, Sulfonamides/pharmacology, Transcription, Up-Regulation/drug effects
Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Tags: *bile acid, *Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, *Farnesoid X receptor, *Homeostasis, *Liver Cirrhosis/chemically induced/enzymology/genetics/prevention & control, *Liver/enzymology/pathology, *nuclear receptor, *Takeda G protein-coupled receptor 5, 2016, Animals, Boehme Shannon, Chiang John Y L, Cholesterol/genetics/*metabolism, Department of Integrative Medical Sciences, G-Protein-Coupled/genetics/metabolism, Hep G2 Cells, Humans, Journal of lipid research, Knockout, Liu Hailiang, Mice, NEOMED College of Medicine, NF-kappa B/genetics/metabolism, Oxidative Stress, Pathak Preeti, Receptors, Tumor Necrosis Factor-alpha/genetics/metabolism
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Tags: *estrogen, *estrogen receptor alpha, *lipid and lipoprotein metabolism, *small heterodimer partner, *triglycerides, *very low density lipoprotein, 2016, Animals, Cholesterol Ester Transfer Proteins/*physiology, Department of Integrative Medical Sciences, Estrogen Receptor alpha/metabolism, Estrogens/physiology, Female, Inbred C57BL, Journal of lipid research, Le Thao D, Lee Yoon-Kwang, Lipid Metabolism, Liver/*metabolism, Metabolic Networks and Pathways, Mice, NEOMED College of Medicine, Oxidation-Reduction, Palmisano Brian T, Stafford John M, Transgenic, Triglycerides/biosynthesis/*blood, Zhu Lin
Cholesterol 7alpha-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Tags: *bile acids and salt/metabolism, *cholesterol/diet, *Lipids, *Liver, 2016, Animal, Animals, Bile Acids and Salts/genetics/metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Diet, Disease Models, Exhalation/genetics, Ferrell Jessica M, Glucose/metabolism, High-Fat, Homeostasis, Humans, Journal of lipid research, Li Feng, Lipid Metabolism/genetics, Liver/enzymology/pathology, Metabolic Diseases/*genetics/metabolism, Mice, NEOMED College of Medicine
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Tags: 2010, 3' Untranslated Regions/genetics, Base Sequence, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Department of Integrative Medical Sciences, Enzymologic/drug effects/*genetics, Fibroblast Growth Factors/pharmacology, Gene Expression Regulation, Genetic/drug effects/genetics, Hep G2 Cells, Hepatocytes/drug effects/enzymology/*metabolism, Humans, Isoxazoles/pharmacology, Journal of lipid research, Li Tiangang, MicroRNAs/*genetics/*metabolism, NEOMED College of Medicine, Oligonucleotide Array Sequence Analysis, Owsley Erika, Post-Transcriptional/drug effects/genetics, RNA Processing, Song Kwang-Hoon, Transcription
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: *Gene Expression Regulation, 2010, Acetylation, AMP-Activated Protein Kinases/metabolism, ATP Citrate (pro-S)-Lyase/genetics/metabolism, Bile Acids and Salts/metabolism, Cells, Chanda Dipanjan, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cultured, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Enzymologic, Epigenesis, Genes, Genetic, Glucose/*administration & dosage, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*enzymology/metabolism, Histones/metabolism, Humans, Hyperglycemia/enzymology/*metabolism, Journal of lipid research, Li Tiangang, Messenger/metabolism, Methylation, NEOMED College of Medicine, Reporter, RNA, RNA Interference, Zhang Yanqiao