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40
29
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Text
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<a href="http://doi.org/10.1152/jn.00409.2020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00409.2020</a>
ISSN
1522-1598
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September 2020 List
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NEOMED College of Medicine
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Department of Anatomy & Neurobiology
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Title
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Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing.
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Journal Of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-23
Subject
The topic of the resource
Swallowing; aspiration; variation; neuromuscular function
Creator
An entity primarily responsible for making the resource
Gould FDH;Lammers Andrew R;Mayerl CJ;Ohlemacher J;German RZ
Description
An account of the resource
Understanding the interactions between neural and musculoskeletal systems is key to identifying mechanisms of functional failure. Mammalian swallowing is a complex, poorly understood motor process. Lesion of the recurrent laryngeal nerve, a sensory and motor nerve of the upper airway, results in airway protection failure (liquid entry into the airway) during swallowing through an unknown mechanism. We examined how muscle and kinematic changes after recurrent laryngeal nerve lesion relate to airway protection in eight infant pigs. We tested two hypotheses: 1) Kinematics and muscle function will both change in response to lesion in swallows with and without airway protection failure 2) Differences in both kinematics and muscle function will predict whether airway protection failure occurs in lesion and intact pigs. We recorded swallowing with high speed videofluoroscopy and simultaneous electromyography of oropharyngeal muscles pre- and post-recurrent laryngeal nerve lesion. Lesion changed the relationship between airway protection and timing of tongue and hyoid movements. Changes in onset and duration of hyolaryngeal muscles post-lesion were less associated with airway protection outcomes. The tongue and hyoid kinematics all predicted airway protection outcomes differently pre and post-lesion. Onset and duration of activity of activity in only one infrahyoid and one suprahyoid muscle showed a change in predictive relationship pre- and post-lesion. Kinematics of the tongue and hyoid more directly reflect changes in airway protection s pre and post lesion than muscle activation patterns. Identifying mechanisms of airway protection failure requires specific functional hypotheses that link neural motor outputs to muscle activation to specific movements.
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<a href="http://doi.org/10.1152/jn.00409.2020" target="_blank" rel="noreferrer noopener">10.1152/jn.00409.2020</a>
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journalArticle
2020
Aspiration
Department of Anatomy & Neurobiology
German RZ
Gould FDH
Journal of neurophysiology
journalArticle
Lammers Andrew R
Mayerl CJ
NEOMED College of Medicine
NEOMED Postdoc Publications
neuromuscular function
Ohlemacher J
September 2020 List
swallowing
Variation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1538-1548
Issue
5
Volume
66
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Hyperpolarizing And Depolarizing Gaba-a Receptor-mediated Dendritic Inhibition In Area Ca1 Of The Rat Hippocampus
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Journal of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
activity-dependent disinhibition; cortical-neurons; depression; electrophysiology; gamma-aminobutyric acid; lacunosum-moleculare interneurons; morphology; Neurosciences & Neurology; Physiology; pyramidal cells-invitro; responses; voltage-clamp
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. Gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABA(A) and late, GABA(B) receptor or-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABA(A) receptor antagonist bicuculline methiodide (BMI; 30-mu-M) and were not changed by the GABA(B) receptor antagonist P-[3-aminopropyl]-P-diethoxymethylphosphinic acid (CGP 35 348; 0.1-1.0 mM). CGP 35 348 (0.1 mM) reversibly blocked late monosynaptic IPSPs and late positive field potentials. These results suggest that fast field potentials are GABA(A) receptor-mediated population IPSPs (GABA(A), fast pIPSPs) and that late field potentials are GABA(B) receptor-mediated population IPSPs (GABA(B), late pIPSPs). 4. Fast pIPSPs were reversibly abolished when the extracellular Cl- concentration ([Cl-1]o) was reduced from 132 to 26 mM in parallel with a depolarizing shift in the reversal potential of fast IPSPs. Paired or repetitive stimulation in s. radiatum reversibly depressed fast pIPSPs and fast IPSPs. Paired-pulse depression of fast pIPSPs was reversibly antagonized by CGP 35 348 (0.40. 8 mM). 5. Laminar analysis of s. radiatum-evoked fast pIPSPs and one-dimensional CSD analysis revealed active current sources in s. radiatum and passive current sinks in s. oriens and s. lacunosum moleculare. S. radiatum sources were abolished by pressure application of BMI in s. radiatum but not in s. oriens. Stimulation in s. oriens, s. pyramidale, or s. lacunosum moleculare evoked GABA(A) current sources horizontal to the stimulation site. Changes in the dendritic location of inhibitory current with changes in stimulus location paralleled changes in the distribution of excitatory current. 6. In the presence of 4-aminopyridine (50-100-mu-M), DNQX and APV long-lasting depolarizing GABA(A) receptor-mediated responses (LLDs) occurred spontaneously or could be evoked. Current sinks associated with s. radiatum-evoked LLDs were located in the same dendritic area as sources associated with hyperpolarizing fast IPSPs. 7. These results suggest that activation of GABA(A) receptors located on pyramidal neuron apical and basal dendrites produces outward Cl-1 current and hyperpolarizing IPSPs. This suggests that depolarizing responses to dendritic GABA application and orthodromic activation in area CA1 do not result from inward chloride current.
Identifier
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n/a
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Journal Article or Conference Abstract Publication
1991
activity-dependent disinhibition
Borroni A M
cortical-neurons
Depression
Electrophysiology
gamma-aminobutyric acid
Grover L M
Journal Article or Conference Abstract Publication
Journal of neurophysiology
lacunosum-moleculare interneurons
Lambert N A
morphology
Neurosciences & Neurology
Physiology
pyramidal cells-invitro
responses
Teyler T J
voltage-clamp
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1993.69.5.1541</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1541-1555
Issue
5
Volume
69
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Title
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Role Of Hco3- Ions In Depolarizing Gaba-a Receptor-mediated Responses In Pyramidal Cells Of Rat Hippocampus
Publisher
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Journal of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
central-nervous-system; cl-channels; cortical-neurons; cultured astrocytes; dendritic inhibition; gamma-aminobutyric acid; glial-cells; guinea-pig hippocampus; long-term potentiation; mammalian; Neurosciences & Neurology; Physiology; synaptic responses
Creator
An entity primarily responsible for making the resource
Grover L M; Lambert N A; Schwartzkroin P A; Teyler T J
Description
An account of the resource
1. Activation of GABA(A) receptors can produce both hyperpolarizing and depolarizing responses in CA1 pyramidal cells. The hyperpolarizing response is mediated by a Cl- conductance, but the ionic basis of the depolarizing response is not clear. We compared the GABA(A) receptor-mediated depolarizations induced by synaptically released gamma-aminobutyric acid [GABA; depolarizing inhibitory postsynaptic potentials (dIPSPs)] with those produced by exogenous GABA (depolarizing GABA responses). Short trains of high-frequency (200 Hz) stimuli were used to generate dIPSPs. We found that dIPSPs generated by trains of stimuli and depolarizing responses to exogenous GABA were accompanied by a conductance increase and had a similar reversal potential, indicating a similar ionic basis for both responses. 2. We wished to determine whether an HCO3- current contributed to the GABA(A)-mediated depolarizations. We found that dIPSPs and depolarizing GABA responses were sensitive to perfusion with HCO3--free medium. Interpretation of these data was complicated by the mixed nature of the responses: dIPSPs were invariably accompanied by conventional, Cl--mediated fast hyperpolarizing IPSPs (fIPSPs), and response to exogenous GABA usually consisted of biphasic hyperpolarizing and depolarizing responses. However, it was sometimes possible to elicit responses to GABA that appeared purely depolarizing (monophasic depolarizing GABA responses). 3. We analyzed monophasic depolarizing GABA responses and found no change in reversal potential when slices were perfused with HCO3--free medium. We also made whole-cell recordings from CA1 pyramidal cells, attempting to reduce [HCO3-]i, and compared the reversal potential for monophasic depolarizing GABA responses with similar responses recorded with fine intracellular microelectrodes. We found no difference in reversal potential. We also examined effects of the carbonic anhydrase inhibitor acetazolamide (ACTZ) on depolarizing GABA responses. ACTZ reduced these responses but did not change their reversal potential. 4. Effects of HCO3--free medium were not specific to GABA(A) receptor-mediated responses. GABA(B) receptor-mediated slow IPSPs (sIPSPs) were also reduced, as were excitatory postsynaptic potentials (EPSPs). Analyses of field potentials and spontaneous fIPSPs suggested a decrease in presynaptic excitability during perfusion with HCO3--free medium. In addition, pyramidal cells showed decreased input resistance when perfused with HCO 3--free medium. 5. The sensitivity of GABA(A) receptor-mediated depolarizations to HCO3--free medium can be explained by a decrease in presynaptic excitability and an increased resting conductance in postsynaptic neurons. Reduced presynaptic excitability and resting input resistance are also likely causes of the reduction in fast IPSPs, slow IPSPs, and EPSPs in HCO3--free medium. We suggest that these nonspecific effects of HCO3--free medium may be a consequence of an extracellular acidification. These data do not provide convincing evidence for involvement of an HCO3- conductance in the generation of dIPSPs and depolarizing GABA responses.
Identifier
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<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">10.1152/jn.1993.69.5.1541</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
central-nervous-system
cl-channels
cortical-neurons
cultured astrocytes
dendritic inhibition
gamma-aminobutyric acid
glial-cells
Grover L M
guinea-pig hippocampus
Journal Article or Conference Abstract Publication
Journal of neurophysiology
Lambert N A
Long-Term Potentiation
Mammalian
Neurosciences & Neurology
Physiology
Schwartzkroin P A
synaptic responses
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
407-431
Issue
3
Volume
51
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Title
A name given to the resource
ANATOMICAL AND FUNCTIONAL-ORGANIZATION OF PATHWAY FROM SUPERIOR COLLICULUS TO LATERAL POSTERIOR NUCLEUS IN HAMSTER
Publisher
An entity responsible for making the resource available
Journal of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1984
1984
Subject
The topic of the resource
Physiology; Neurosciences & Neurology
Creator
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Mooney R D; Fish S E; Rhoades R W
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n/a
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Journal Article or Conference Abstract Publication
1984
Fish S E
Journal Article or Conference Abstract Publication
Journal of neurophysiology
Mooney R D
Neurosciences & Neurology
Physiology
Rhoades R W
-
Text
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URL Address
<a href="http://doi.org/10.1152/jn.1998.79.1.334" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1998.79.1.334</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
334-341
Issue
1
Volume
79
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Title
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Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1
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Journal of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
aged fischer-344 rats; alzheimers-disease; calcium channels; concentration-dependent manner; cortex; ltp induction; Neurosciences & Neurology; nmda receptors; Physiology; prefrontal; pyramidal neurons; synaptic transmission; visual cortex
Creator
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Shankar S; Teyler T J; Robbins N
Description
An account of the resource
Aging differentially alters forms of long-term potentiation in rat hippocampal area CAl. J. Neurophysiol. 79: 334-341, 1998. Long-term potentiation (LTP) of the Schaffer collateral/commissural inputs to CAI in the hippocampus was shown to consist of N-methyl-D-aspartate receptor (NMDAR) and voltage-dependent calcium channel (VDCC) dependent forms. In this study, the relative contributions of these two forms of LTP in in vitro hippocampal slices from young (2 mo) and old (24 mo) Fischer 344 rats were examined. Excitatory postsynaptic potentials (EPSP) were recorded extracellularly from stratum radiat-um before and after II tetanic stimulus consisting of four 200-Hz, 0.5-s trains given 5 s apart. Under control conditions, a compound LTP consisting of both forms was induced and was similar, in both time course and magnitude, in young and old animals. NMDAR-dependent LTP (nmdaLTP), isolated by the application of 10 mu M nifedipine (a voltage-dependent calcium channel blocker), was significantly reduced in magnitude in aged animals. The VDCC dependent form (vdccLTP), isolated by the application of 50 mu M D,L-2-amino-5-phosphonvalerate (APV), was significantly larger in aged animals. Although both LTP forms reached stable values 40-60 min posttetanus in young animals, in aged animals vdccLTP increased and nmdaLTP decreased during this time. In both young and old animals, the sum of the two isolated LTP forms approximated the magnitude of the compound LTP, and application of APV and nifedipine or genestein (a tyrosine kinase inhibitor) together blocked potentiation. These results suggest that aging causes a shift in synaptic plasticity from NMDAR-dependent mechanisms to VDCC-dependent mechanisms. The data are consistent with previous findings of increased L-type calcium current and decreased NMDAR number In aged CAI cells and may help explain age-related deficits in learning and memory.
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<a href="http://doi.org/10.1152/jn.1998.79.1.334" target="_blank" rel="noreferrer noopener">10.1152/jn.1998.79.1.334</a>
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The file format, physical medium, or dimensions of the resource
Journal Article
1998
aged fischer-344 rats
alzheimers-disease
Calcium Channels
concentration-dependent manner
cortex
Journal Article
Journal of neurophysiology
ltp induction
Neurosciences & Neurology
nmda receptors
Physiology
prefrontal
pyramidal neurons
Robbins N
Shankar S
Synaptic Transmission
Teyler T J
visual cortex
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.91300.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.91300.2008</a>
Pages
167–180
Issue
1
Volume
102
Dublin Core
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Title
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Temporal features of spectral integration in the inferior colliculus: effects of stimulus duration and rise time.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-07
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/physiology; Animals; Auditory Perception/*physiology; Auditory Threshold/*physiology; Chiroptera/physiology; Inferior Colliculi/*cytology; Neural Inhibition/physiology; Neurons/*physiology; Predictive Value of Tests; Psycholinguistics; Reaction Time/*physiology; Time Factors; Wakefulness/physiology
Creator
An entity primarily responsible for making the resource
Gans Donald; Sheykholeslami Kianoush; Peterson Diana Coomes; Wenstrup Jeffrey
Description
An account of the resource
This report examines temporal features of facilitation and suppression that underlie spectrally integrative responses to complex vocal signals. Auditory responses were recorded from 160 neurons in the inferior colliculus (IC) of awake mustached bats. Sixty-two neurons showed combination-sensitive facilitation: responses to best frequency (BF) signals were facilitated by well-timed signals at least an octave lower in frequency, in the range 16-31 kHz. Temporal features and strength of facilitation were generally unaffected by changes in duration of facilitating signals from 4 to 31 ms. Changes in stimulus rise time from 0.5 to 5.0 ms had little effect on facilitatory strength. These results suggest that low frequency facilitating inputs to high BF neurons have phasic-on temporal patterns and are responsive to stimulus rise times over the tested range. We also recorded from 98 neurons showing low-frequency (11-32 kHz) suppression of higher BF responses. Effects of changing duration were related to the frequency of suppressive signals. Signals\textless23 kHz usually evoked suppression sustained throughout signal duration. This and other features of such suppression are consistent with a cochlear origin that results in masking of responses to higher, near-BF signal frequencies. Signals in the 23- to 30-kHz range-frequencies in the first sonar harmonic-generally evoked phasic suppression of BF responses. This may result from neural inhibitory interactions within and below IC. In many neurons, we observed two or more forms of the spectral interactions described here. Thus IC neurons display temporally and spectrally complex responses to sound that result from multiple spectral interactions at different levels of the ascending auditory pathway.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.91300.2008" target="_blank" rel="noreferrer noopener">10.1152/jn.91300.2008</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Acoustic Stimulation/methods
Action Potentials/physiology
Animals
Auditory Perception/*physiology
Auditory Threshold/*physiology
Chiroptera/physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Gans Donald
Inferior Colliculi/*cytology
Journal of neurophysiology
NEOMED College of Medicine
Neural Inhibition/physiology
Neurons/*physiology
Peterson Diana Coomes
Predictive Value of Tests
Psycholinguistics
Reaction Time/*physiology
Sheykholeslami Kianoush
Time Factors
Wakefulness/physiology
Wenstrup Jeffrey
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.90390.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.90390.2008</a>
Pages
629–645
Issue
2
Volume
100
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intracellular recordings from combination-sensitive neurons in the inferior colliculus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-08
Subject
The topic of the resource
Acoustic Stimulation/methods; Afferent/classification/*physiology; Animals; Auditory/physiology; Biological; Chiroptera; Evoked Potentials; Inferior Colliculi/*cytology; Membrane Potentials/physiology/radiation effects; Models; Neural Inhibition/*physiology; Neural Pathways/physiology; Neurons; Psychophysics; Reaction Time; Wakefulness
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Voytenko Sergiy; Gans Donald; Galazyuk Alexander; Wenstrup Jeffrey
Description
An account of the resource
In vertebrate auditory systems, specialized combination-sensitive neurons analyze complex vocal signals by integrating information across multiple frequency bands. We studied combination-sensitive interactions in neurons of the inferior colliculus (IC) of awake mustached bats, using intracellular somatic recording with sharp electrodes. Facilitated combinatorial neurons are coincidence detectors, showing maximum facilitation when excitation from low- and high-frequency stimuli coincide. Previous work showed that facilitatory interactions originate in the IC, require both low and high frequency-tuned glycinergic inputs, and are independent of glutamatergic inputs. These results suggest that glycinergic inputs evoke facilitation through either postinhibitory rebound or direct depolarizing mechanisms. However, in 35 of 36 facilitated neurons, we observed no evidence of low frequency-evoked transient hyperpolarization or depolarization that was closely related to response facilitation. Furthermore, we observed no evidence of shunting inhibition that might conceal inhibitory inputs. Since these facilitatory interactions originate in IC neurons, the results suggest that inputs underlying facilitation are electrically segregated from the soma. We also recorded inhibitory combinatorial interactions, in which low frequency sounds suppress responses to higher frequency signals. In 43% of 118 neurons, we observed low frequency-evoked hyperpolarizations associated with combinatorial inhibition. For these neurons, we conclude that low frequency-tuned inhibitory inputs terminate on neurons primarily excited by high-frequency signals; these inhibitory inputs may create or enhance inhibitory combinatorial interactions. In the remainder of inhibited combinatorial neurons (57%), we observed no evidence of low frequency-evoked hyperpolarizations, consistent with observations that inhibitory combinatorial responses may originate in lateral lemniscal nuclei.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.90390.2008" target="_blank" rel="noreferrer noopener">10.1152/jn.90390.2008</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Acoustic Stimulation/methods
Afferent/classification/*physiology
Animals
Auditory/physiology
Biological
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk Alexander
Gans Donald
Inferior Colliculi/*cytology
Journal of neurophysiology
Membrane Potentials/physiology/radiation effects
Models
NEOMED College of Medicine
Neural Inhibition/*physiology
Neural Pathways/physiology
Neurons
Peterson Diana Coomes
Psychophysics
Reaction Time
Voytenko Sergiy
Wakefulness
Wenstrup Jeffrey
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.2001.86.3.1289</a>
Pages
1289–1296
Issue
3
Volume
86
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Electrical stimuli patterned after the theta-rhythm induce multiple forms of LTP.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-09
Subject
The topic of the resource
*Theta Rhythm; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Calcium Channel Blockers/pharmacology; Calcium Channels/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; Long-Evans; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/physiology; N-Methylaspartate/pharmacology; Neuronal Plasticity/drug effects/*physiology; Nifedipine/pharmacology; Organ Culture Techniques; Rats; Receptors
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
The induction of long-term potentiation (LTP) by high-frequency stimulation is considered an acceptable model for the study of learning and memory. In area CA1 calcium influx through N-methyl-D-aspartate receptors (NMDARs; nmdaLTP) and/or
Identifier
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<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">10.1152/jn.2001.86.3.1289</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Theta Rhythm
2-Amino-5-phosphonovalerate/pharmacology
2001
Animals
Calcium Channel Blockers/pharmacology
Calcium Channels/physiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/drug effects/*physiology
Male
Morgan S L
N-Methyl-D-Aspartate/physiology
N-Methylaspartate/pharmacology
Neuronal Plasticity/drug effects/*physiology
Nifedipine/pharmacology
Organ Culture Techniques
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1999.82.5.2528" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1999.82.5.2528</a>
Pages
2528–2544
Issue
5
Volume
82
Dublin Core
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Title
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Frequency organization and responses to complex sounds in the medial geniculate body of the mustached bat.
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-11
Subject
The topic of the resource
*Brain Mapping; Animal; Animals; Auditory Cortex/*physiology; Auditory Perception/*physiology; Chiroptera/*physiology; Electrophysiology/methods; Geniculate Bodies/*physiology; Neurons/*physiology; Pitch Discrimination/*physiology; Reaction Time; Ultrasonics; Vocalization
Creator
An entity primarily responsible for making the resource
Wenstrup J J
Description
An account of the resource
The auditory cortex of the mustached bat (Pteronotus parnellii) displays some of the most highly developed physiological and organizational features described in mammalian auditory cortex. This study examines response properties and organization in the medial geniculate body (MGB) that may contribute to these features of auditory cortex. About 25% of 427 auditory responses had simple frequency tuning with single excitatory tuning curves. The remainder displayed more complex frequency tuning using two-tone or noise stimuli. Most of these were combination-sensitive, responsive to combinations of different frequency bands within sonar or social vocalizations. They included FM-FM neurons, responsive to different harmonic elements of the frequency modulated (FM) sweep in the sonar signal, and H1-CF neurons, responsive to combinations of the bat's first sonar harmonic (H1) and a higher harmonic of the constant frequency (CF) sonar signal. Most combination-sensitive neurons (86%) showed facilitatory interactions. Neurons tuned to frequencies outside the biosonar range also displayed combination-sensitive responses, perhaps related to analyses of social vocalizations. Complex spectral responses were distributed throughout dorsal and ventral divisions of the MGB, forming a major feature of this bat's analysis of complex sounds. The auditory sector of the thalamic reticular nucleus also was dominated by complex spectral responses to sounds. The ventral division was organized tonotopically, based on best frequencies of singly tuned neurons and higher best frequencies of combination-sensitive neurons. Best frequencies were lowest ventrolaterally, increasing dorsally and then ventromedially. However, representations of frequencies associated with higher harmonics of the FM sonar signal were reduced greatly. Frequency organization in the dorsal division was not tonotopic; within the middle one-third of MGB, combination-sensitive responses to second and third harmonic CF sonar signals (60-63 and 90-94 kHz) occurred in adjacent regions. In the rostral one-third, combination-sensitive responses to second, third, and fourth harmonic FM frequency bands predominated. These FM-FM neurons, thought to be selective for delay between an emitted pulse and echo, showed some organization of delay selectivity. The organization of frequency sensitivity in the MGB suggests a major rewiring of the output of the central nucleus of the inferior colliculus, by which collicular neurons tuned to the bat's FM sonar signals mostly project to the dorsal, not the ventral, division. Because physiological differences between collicular and MGB neurons are minor, a major role of the tecto-thalamic projection in the mustached bat may be the reorganization of responses to provide for cortical representations of sonar target features.
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<a href="http://doi.org/10.1152/jn.1999.82.5.2528" target="_blank" rel="noreferrer noopener">10.1152/jn.1999.82.5.2528</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain Mapping
1999
Animal
Animals
Auditory Cortex/*physiology
Auditory Perception/*physiology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrophysiology/methods
Geniculate Bodies/*physiology
Journal of neurophysiology
NEOMED College of Medicine
Neurons/*physiology
Pitch Discrimination/*physiology
Reaction Time
Ultrasonics
Vocalization
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1999.82.3.1326" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1999.82.3.1326</a>
Pages
1326–1338
Issue
3
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Delay-tuned neurons in the inferior colliculus of the mustached bat: implications for analyses of target distance.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-09
Subject
The topic of the resource
Animal/physiology; Animals; Chiroptera/*physiology; Echolocation/*physiology; Inferior Colliculi/cytology/*physiology; Neural Inhibition/physiology; Neurons/*physiology; Reaction Time/physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Portfors C V; Wenstrup J J
Description
An account of the resource
We examined response properties of delay-tuned neurons in the central nucleus of the inferior colliculus (ICC) of the mustached bat. In the mustached bat, delay-tuned neurons respond best to the combination of the first-harmonic, frequency-modulated (FM1) sweep in the emitted pulse and a higher harmonic frequency-modulated (FM2, FM3 or FM4) component in returning echoes and are referred to as FM-FM neurons. We also examined H1-CF2 neurons. H1-CF2 neurons responded to simultaneous presentation of the first harmonic (H1) in the emitted pulse and the second constant frequency (CF2) component in returning echoes. These neurons served as a comparison as they are thought to encode different features of sonar targets than FM-FM neurons. Only 7% of our neurons (14/198) displayed a single excitatory tuning curve. The rest of the neurons (184) displayed complex responses to sounds in two separate frequency bands. The majority (51%, 101) of neurons were facilitated by the combination of specific components in the mustached bat's vocalizations. Twenty-five percent showed purely inhibitory interactions. The remaining neurons responded to two separate frequencies, without any facilitation or inhibition. FM-FM neurons (69) were facilitated by the FM1 component in the simulated pulse and a higher harmonic FM component in simulated echoes, provided the high-frequency signal was delayed the appropriate amount. The delay producing maximal facilitation ("best delay") among
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<a href="http://doi.org/10.1152/jn.1999.82.3.1326" target="_blank" rel="noreferrer noopener">10.1152/jn.1999.82.3.1326</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animal/physiology
Animals
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/*physiology
Inferior Colliculi/cytology/*physiology
Journal of neurophysiology
NEOMED College of Medicine
Neural Inhibition/physiology
Neurons/*physiology
Portfors C V
Reaction Time/physiology
Vocalization
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1999.82.2.736" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1999.82.2.736</a>
Pages
736–740
Issue
2
Volume
82
Dublin Core
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Title
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VDCCs and NMDARs underlie two forms of LTP in CA1 hippocampus in vivo.
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-08
Subject
The topic of the resource
Animals; Calcium Channel Blockers/*pharmacology; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/*pharmacology; Excitatory Postsynaptic Potentials/drug effects; Hippocampus/*drug effects; Long-Evans; Long-Term Potentiation/*drug effects; Male; Membrane Potentials/physiology; N-Methyl-D-Aspartate/*antagonists & inhibitors; Rats; Receptors; Verapamil/pharmacology
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
N-methyl-D-aspartate receptor/channel (NMDAR) and voltage-dependent calcium channel (VDCC) antagonists applied independently reduce the magnitude of long-term potentiation (LTP) in area CA1 of the hippocampal slice preparation. When used in combination, the antagonists completely block the induction of LTP. In urethan-anesthetized rats we examined the effect of the NMDAR blocker MK-801 (0.1 mg/kg) and the VDCC blocker Verapamil (10 mg/kg) on LTP induction in area CA1. Extracellular recordings were obtained from stratum radiatum following stimulation of Schaffer collaterals. LTP was induced by a 200-Hz/100-ms tetanus repeated 10 times (2 s isi). Tetanus was given in the presence of intraperitoneal saline, MK-801, Verapamil, or both Verapamil and MK-801. When given separately, Verapamil and MK-801 both significantly reduced the magnitude of LTP as compared with control animals. When given together, the drugs blocked the induction of LTP completely. We conclude that like LTP in vitro, VDCCs and NMDAR underlie two forms of LTP in vivo.
Identifier
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<a href="http://doi.org/10.1152/jn.1999.82.2.736" target="_blank" rel="noreferrer noopener">10.1152/jn.1999.82.2.736</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Animals
Calcium Channel Blockers/*pharmacology
Dizocilpine Maleate/pharmacology
Excitatory Amino Acid Antagonists/*pharmacology
Excitatory Postsynaptic Potentials/drug effects
Hippocampus/*drug effects
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/*drug effects
Male
Membrane Potentials/physiology
Morgan S L
N-Methyl-D-Aspartate/*antagonists & inhibitors
Rats
Receptors
Teyler T J
Verapamil/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1996.76.5.3038" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1996.76.5.3038</a>
Pages
3038–3047
Issue
5
Volume
76
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Two forms of long-term potentiation in area CA1 activate different signal transduction cascades.
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-11
Subject
The topic of the resource
Animals; Hippocampus/drug effects/*physiology; Long-Term Potentiation/drug effects/*physiology; Nifedipine/pharmacology; Rats; Signal Transduction/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Cavus I; Teyler T
Description
An account of the resource
1. The effects of protein kinase inhibitors on N-methyl-D-aspartate (NMDA)-receptor-mediated, voltage-dependent calcium channel (VDCC)-mediated, and
Identifier
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<a href="http://doi.org/10.1152/jn.1996.76.5.3038" target="_blank" rel="noreferrer noopener">10.1152/jn.1996.76.5.3038</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Cavus I
Hippocampus/drug effects/*physiology
Journal of neurophysiology
Long-Term Potentiation/drug effects/*physiology
Nifedipine/pharmacology
Rats
Signal Transduction/drug effects/*physiology
Teyler T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1993.69.5.1541</a>
Pages
1541–1555
Issue
5
Volume
69
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
Afferent Pathways/physiology; Animals; Bicarbonates/*metabolism; Culture Techniques; Electric Stimulation; GABA-A/*physiology; gamma-Aminobutyric Acid/physiology; Hippocampus/*physiology; Interneurons/physiology; Membrane Potentials/physiology; Neurons/physiology; Rats; Receptors; Synapses/physiology; Synaptic Transmission/*physiology
Creator
An entity primarily responsible for making the resource
Grover L M; Lambert N A; Schwartzkroin P A; Teyler T J
Description
An account of the resource
1. Activation of GABAA receptors can produce both hyperpolarizing and depolarizing responses in CA1 pyramidal cells. The hyperpolarizing response is mediated by a Cl- conductance, but the ionic basis of the depolarizing response is not clear. We compared the GABAA receptor-mediated depolarizations induced by synaptically released gamma-aminobutyric acid [GABA; depolarizing inhibitory postsynaptic potentials (dIPSPs)] with those produced by exogenous GABA (depolarizing GABA responses). Short trains of high-frequency (200 Hz) stimuli were used to generate dIPSPs. We found that dIPSPs generated by trains of stimuli and depolarizing responses to exogenous GABA were accompanied by a conductance increase and had a similar reversal potential, indicating a similar ionic basis for both responses. 2. We wished to determine whether an HCO3- current contributed to the GABAA-mediated depolarizations. We found that dIPSPs and depolarizing GABA responses were sensitive to perfusion with HCO3(-)-free medium. Interpretation of these data was complicated by the mixed nature of the responses: dIPSPs were invariably accompanied by conventional, Cl(-)-mediated fast hyperpolarizing IPSPs (fIPSPs), and response to exogenous GABA usually consisted of biphasic hyperpolarizing and depolarizing responses. However, it was sometimes possible to elicit responses to GABA that appeared purely depolarizing (monophasic depolarizing GABA responses). 3. We analyzed monophasic depolarizing GABA responses and found no change in reversal potential when slices were perfused with HCO(3-)-free medium. We also made whole-cell recordings from CA1 pyramidal cells, attempting to reduce [HCO3-]i, and compared the reversal potential for monophasic depolarizing GABA responses with similar responses recorded with fine intracellular microelectrodes. We found no difference in reversal potential. We also examined effects of the carbonic anhydrase inhibitor acetazolamide (ACTZ) on depolarizing GABA responses. ACTZ reduced these responses but did not change their reversal potential. 4. Effects of HCO(3-)-free medium were not specific to GABAA receptor-mediated responses. GABAB receptor-mediated slow IPSPs (sIPSPs) were also reduced, as were excitatory postsynaptic potentials (EPSPs). Analyses of field potentials and spontaneous fIPSPs suggested a decrease in presynaptic excitability during perfusion with HCO(3-)-free medium. In addition, pyramidal cells showed decreased input resistance when perfused with HCO(3-)-free medium. 5. The sensitivity of GABAA receptor-mediated depolarizations to HCO(3-)-free medium can be explained by a decrease in presynaptic excitability and an increased resting conductance in postsynaptic neurons.(ABSTRACT TRUNCATED AT 400 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">10.1152/jn.1993.69.5.1541</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent Pathways/physiology
Animals
Bicarbonates/*metabolism
Culture Techniques
Electric Stimulation
GABA-A/*physiology
gamma-Aminobutyric Acid/physiology
Grover L M
Hippocampus/*physiology
Interneurons/physiology
Journal of neurophysiology
Lambert N A
Membrane Potentials/physiology
Neurons/physiology
Rats
Receptors
Schwartzkroin P A
Synapses/physiology
Synaptic Transmission/*physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1991.66.5.1538</a>
Pages
1538–1548
Issue
5
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Bicuculline/analogs & derivatives/pharmacology; Chlorides/pharmacology; Dendrites/drug effects/*physiology; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/*physiology; Hippocampus/*physiology; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials/drug effects; Models; Neurological; Neurons/drug effects/*physiology; Organophosphorus Compounds/pharmacology; Pyramidal Tracts/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABAA and late, GABAB receptor-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) and were not changed by the GABAB receptor antagonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">10.1152/jn.1991.66.5.1538</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Bicuculline/analogs & derivatives/pharmacology
Borroni A M
Chlorides/pharmacology
Dendrites/drug effects/*physiology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lambert N A
Mathematics
Membrane Potentials/drug effects
Models
Neurological
Neurons/drug effects/*physiology
Organophosphorus Compounds/pharmacology
Pyramidal Tracts/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01152.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01152.2004</a>
Pages
3294–3312
Issue
6
Volume
93
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Roles of inhibition in creating complex auditory responses in the inferior colliculus: facilitated combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-06
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/*physiology; Animals; Auditory Pathways/physiology; Bicuculline/pharmacology; Cell Count; Drug Interactions; GABA Antagonists/pharmacology; Glycine Agents/pharmacology; Inferior Colliculi/*cytology; Iontophoresis/methods; Models; Neural Inhibition/drug effects/*physiology; Neurological; Neurons/classification/drug effects/*physiology/radiation effects; Otters; Reaction Time/*physiology/radiation effects; Regression Analysis; Strychnine/pharmacology; Time Factors; Wakefulness/physiology
Creator
An entity primarily responsible for making the resource
Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied roles of inhibition on temporally sensitive facilitation in combination-sensitive neurons from the mustached bat's inferior colliculus (IC). In these integrative neurons, excitatory responses to best frequency (BF) tones are enhanced by much lower frequency signals presented in a specific temporal relationship. Most facilitated neurons (76%) showed inhibition at delays earlier than or later than the delays causing facilitation. The timing of inhibition at earlier delays was closely related to the best delay of facilitation, but the inhibition had little influence on the duration or strength of the facilitatory interaction. Local iontophoretic application of antagonists to receptors for glycine (strychnine, STRY) and gamma-aminobutyric acid (GABA) (bicuculline, BIC) showed that STRY abolished facilitation in 96% of tested units, but BIC eliminated facilitation in only 28%. This suggests that facilitatory interactions are created in IC and reveals a differential role for these neurotransmitters. The facilitation may be created by coincidence of a postinhibitory rebound excitation activated by the low-frequency signal with the BF-evoked excitation. Unlike facilitation, inhibition at earlier delays was not eliminated by application of antagonists, suggesting an origin in lower brain stem nuclei. However, inhibition at delays later than facilitation, like facilitation itself, appears to originate within IC and to be more dependent on glycinergic than GABAergic mechanisms. Facilitatory and inhibitory interactions displayed by these combination-sensitive neurons encode information within sonar echoes and social vocalizations. The results indicate that these complex response properties arise through a series of neural interactions in the auditory brain stem and midbrain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.01152.2004" target="_blank" rel="noreferrer noopener">10.1152/jn.01152.2004</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Acoustic Stimulation/methods
Action Potentials/*physiology
Animals
Auditory Pathways/physiology
Bicuculline/pharmacology
Cell Count
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Drug Interactions
GABA Antagonists/pharmacology
Glycine Agents/pharmacology
Inferior Colliculi/*cytology
Iontophoresis/methods
Journal of neurophysiology
Models
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurological
Neurons/classification/drug effects/*physiology/radiation effects
Otters
Reaction Time/*physiology/radiation effects
Regression Analysis
Strychnine/pharmacology
Time Factors
Wakefulness/physiology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01148.2005</a>
Pages
2179–2192
Issue
4
Volume
95
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Roles of inhibition in complex auditory responses in the inferior colliculus: inhibited combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects/physiology; Afferent/drug effects/*physiology; Animals; Auditory; Auditory Pathways/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; GABA-A/physiology; Glycine/antagonists & inhibitors/physiology; Inferior Colliculi/*physiology; Neural Inhibition/drug effects/*physiology; Neurons; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied the functional properties and underlying neural mechanisms associated with inhibitory combination-sensitive neurons in the mustached bat's inferior colliculus (IC). In these neurons, the excitatory response to best frequency tones was suppressed by lower frequency signals (usually in the range of 12-30 kHz) in a time-dependant manner. Of 143 inhibitory units, the majority (71%) were type I, in which low-frequency sounds evoked inhibition only. In the remainder, however, the low-frequency inhibitory signal also evoked excitation. Of these, excitation preceded the inhibition in type E/I units (16%), whereas in type I/E units (13%), excitation followed the inhibition. Type E/I and I/E units were distinct in the tuning and threshold sensitivity of low-frequency responses, whereas type I units overlapped the other types in these features. In 71 neurons, antagonists to receptors for glycine [strychnine (STRY)] or GABA [bicuculline (BIC)] were applied microiontophoretically. These antagonists failed to eliminate combination-sensitive inhibition in 92% (STRY), 93% (BIC), and 87% (BIC + STRY) of the type I units tested. However, inhibition was reduced in many neurons. Results were similar for type E/I and I/E inhibitory neurons. The results indicate that there are distinct populations of combination-sensitive inhibited neurons in the IC and that these populations are at least partly independent of glycine or GABAA receptors in the IC. We propose that these populations originate in different brain stem auditory nuclei, that they may be modified by interactions within the IC, and that they may perform different spectrotemporal analyses of vocal signals.
Identifier
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<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.01148.2005</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Acoustic Stimulation
Action Potentials/drug effects/physiology
Afferent/drug effects/*physiology
Animals
Auditory
Auditory Pathways/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrophysiology
Evoked Potentials
GABA-A Receptor Antagonists
GABA-A/physiology
Glycine/antagonists & inhibitors/physiology
Inferior Colliculi/*physiology
Journal of neurophysiology
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00976.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00976.2006</a>
Pages
1368–1378
Issue
2
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intracellular recording reveals temporal integration in inferior colliculus neurons of awake bats.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
Acoustic Stimulation; Animals; Chiroptera/*physiology; Data Interpretation; Electrophysiology; Excitatory Postsynaptic Potentials/physiology; Inferior Colliculi/cytology/*physiology; Inhibitory Postsynaptic Potentials/physiology; Microelectrodes; Neurons/*physiology; Pitch Perception; Statistical
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
The central nucleus of the inferior colliculus (IC) is a major integrative center in the central auditory system. It receives information from both the ascending and descending auditory pathways. To determine how single IC neurons integrate information over a wide range of sound frequencies and sound levels, we examined their intracellular responses to frequency-modulated (FM) sounds in awake little brown bats (Myotis lucifugus). Postsynaptic potentials were recorded in response to downward FM sweeps of the range typical for little brown bats (80-20 kHz) and to three FM subcomponents (80-60, 60-40, and 40-20 kHz). The majority of recorded neurons responded to the 80- to 20-kHz downward FM sweep with a complex response. In this response an initial hyperpolarization was followed by depolarization with or without spike followed by hyperpolarization. Intracellular recordings in response to three FM subcomponents revealed that these neurons receive excitatory and inhibitory inputs from a wide range of sound frequencies. One third of IC neurons performed nearly linear temporal summation across a wide range of sound frequencies, whereas two thirds of IC neurons exhibited nonlinear summation with different degrees of nonlinearity. Some IC neurons showed different latencies of postsynaptic potentials in response to different FM subcomponents. Often responses to the later FM subcomponent occurred before responses to the earlier ones. This phenomenon may be responsible for response selectivity of IC neurons to FM sweeps.
Identifier
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<a href="http://doi.org/10.1152/jn.00976.2006" target="_blank" rel="noreferrer noopener">10.1152/jn.00976.2006</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Acoustic Stimulation
Animals
Chiroptera/*physiology
Data Interpretation
Department of Anatomy & Neurobiology
Electrophysiology
Excitatory Postsynaptic Potentials/physiology
Galazyuk A V
Inferior Colliculi/cytology/*physiology
Inhibitory Postsynaptic Potentials/physiology
Journal of neurophysiology
Microelectrodes
NEOMED College of Medicine
Neurons/*physiology
Pitch Perception
Statistical
Voytenko S V
-
Text
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URL Address
<a href="http://doi.org/10.1152/jn.00953.2015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00953.2015</a>
Pages
868–886
Issue
2
Volume
115
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Two distinct representations of social vocalizations in the basolateral amygdala.
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-02
Subject
The topic of the resource
*Discrimination (Psychology); *Social Behavior; *Vocalization; acoustic communication; Action Potentials; Amygdala/cytology/*physiology; Animal; Animals; bat; Chiroptera; electrocardiogram; Eptesicus fuscus; Female; Heart Rate; Male; Neurons/classification/*physiology; vocalizations
Creator
An entity primarily responsible for making the resource
Gadziola Marie A; Shanbhag Sharad J; Wenstrup Jeffrey J
Description
An account of the resource
Acoustic communication signals carry information related to the types of social interactions by means of their "acoustic context," the sequencing and temporal emission pattern of vocalizations. Here we describe responses to natural vocal sequences in adult big brown bats (Eptesicus fuscus). We first assessed how vocal sequences modify the internal affective state of a listener (via heart rate). The heart rate of listening bats was differentially modulated by vocal sequences, showing significantly greater elevation in response to moderately aggressive sequences than appeasement or neutral sequences. Next, we characterized single-neuron responses in the basolateral amygdala (BLA) of awake, restrained bats to isolated syllables and vocal sequences. Two populations of neurons distinguished by background firing rates also differed in acoustic stimulus selectivity. Low-background neurons (\textless1 spike/s) were highly selective, responding on average to one tested stimulus. These may participate in a sparse code of vocal stimuli, in which each neuron responds to one or a few stimuli and the population responds to the range of vocalizations across behavioral contexts. Neurons with higher background rates (\textgreater/=1 spike/s) responded broadly to tested stimuli and better represented the timing of syllables within sequences. We found that spike timing information improved the ability of these neurons to discriminate among vocal sequences and among the behavioral contexts associated with sequences compared with a rate code alone. These findings demonstrate that the BLA contains multiple robust representations of vocal stimuli that can provide the basis for emotional/physiological responses to these stimuli.
Identifier
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<a href="http://doi.org/10.1152/jn.00953.2015" target="_blank" rel="noreferrer noopener">10.1152/jn.00953.2015</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)
*Social Behavior
*Vocalization
2016
acoustic communication
Action Potentials
Amygdala/cytology/*physiology
Animal
Animals
bat
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
electrocardiogram
Eptesicus fuscus
Female
Gadziola Marie A
Heart Rate
Journal of neurophysiology
Male
NEOMED College of Medicine
Neurons/classification/*physiology
Shanbhag Sharad J
vocalizations
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00883.2006</a>
Pages
1018–1029
Issue
2
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Amino Acids/pharmacology; Animals; Chickens/*physiology; Cochlear Nucleus/*cytology/*physiology; Electric Stimulation; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/physiology; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; GABA-B/physiology; gamma-Aminobutyric Acid/*physiology; Glycine/analogs & derivatives/pharmacology; In Vitro Techniques; Kinetics; Membrane Potentials/drug effects; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology; Models; Neurological; Neurons/*physiology; Patch-Clamp Techniques; Receptors; Resorcinols/pharmacology; Synapses/physiology; Synaptic Transmission/*physiology; Xanthenes/pharmacology
Creator
An entity primarily responsible for making the resource
Lu Yong
Description
An account of the resource
GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic glutamate receptors (mGluRs) with whole cell recordings in brain slice preparations. I found that tACPD, a nonspecific mGluR agonist, exerted dose-dependent suppression on evoked inhibitory postsynaptic currents (eIPSCs) in NM neurons. At concentrations of 100 or 200 microM, tACPD increased the failure rate of GABAergic transmission. Agonists for group I (3,5-DHPG, 200 microM), group II (DCG-IV, 2 microM), and group III (L-AP4, 10 microM) mGluRs produced a significant reduction in the amplitude of eIPSCs and a significant increase in failure rate, indicating the involvement of multiple mGluRs in this modulation. The frequency, but not the amplitude, of miniature IPSCs (mIPSCs) was decreased significantly by 3,5-DHPG or DCG-IV. Neither frequency nor amplitude of mIPSCs was affected by L-AP4. mGluR antagonists LY341495 (20 microM) plus CPPG (10 microM) significantly increased the amplitude of eIPSCs, indicating that endogenous mGluR activity suppresses GABA release to NM neurons. Furthermore, blockage of mGluRs increased GABA-evoked discharges recorded under physiological Cl(-) concentrations, whereas tACPD (100 microM) eliminated them. The results indicate that mGluRs play important roles in achieving balanced excitation and inhibition in NM and preserving fidelity of temporal information encoded by NM neurons.
Identifier
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<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">10.1152/jn.00883.2006</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2-Amino-5-phosphonovalerate/pharmacology
2007
Amino Acids/pharmacology
Animals
Chickens/*physiology
Cochlear Nucleus/*cytology/*physiology
Department of Anatomy & Neurobiology
Electric Stimulation
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/physiology
GABA-B Receptor Agonists
GABA-B Receptor Antagonists
GABA-B/physiology
gamma-Aminobutyric Acid/*physiology
Glycine/analogs & derivatives/pharmacology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lu Yong
Membrane Potentials/drug effects
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology
Models
NEOMED College of Medicine
Neurological
Neurons/*physiology
Patch-Clamp Techniques
Receptors
Resorcinols/pharmacology
Synapses/physiology
Synaptic Transmission/*physiology
Xanthenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00657.2016</a>
Pages
2550–2563
Issue
6
Volume
116
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-type calcium channels refine the neural population code of sound level.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-12
Subject
The topic of the resource
*auditory midbrain; *dynamic range; *inferior colliculus; *level tuning; *local circuits; *rate-level functions; *Sound; 4-Aminopyridine/analogs & derivatives/pharmacology; Acoustic Stimulation; Action Potentials/drug effects/*physiology; Amifampridine; Animals; Biophysical Phenomena/drug effects; Calcium Channel Blockers/pharmacology; Calcium Channels; Calcium/metabolism; Excitatory Amino Acid Antagonists/pharmacology; In Vitro Techniques; Inbred CBA; Inferior Colliculi/*cytology; L-Type/*metabolism; Mice; Neurons/*physiology; Nimodipine/pharmacology; omega-Conotoxin GVIA/pharmacology; Potassium Channel Blockers/pharmacology; Quinoxalines/pharmacology; Wakefulness
Creator
An entity primarily responsible for making the resource
Grimsley Calum Alex; Green David Brian; Sivaramakrishnan Shobhana
Description
An account of the resource
The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (CaL: CaV1.1-1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of CaL to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. CaL is a high-threshold current and comprises approximately 50% of the total calcium current in ICC neurons. In vivo, CaL activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, CaL boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, CaL either suppresses or enhances firing at sound levels that evoke maximum firing. CaL multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level.
Identifier
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<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">10.1152/jn.00657.2016</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*auditory midbrain
*dynamic range
*Inferior colliculus
*level tuning
*local circuits
*rate-level functions
*Sound
2016
4-Aminopyridine/analogs & derivatives/pharmacology
Acoustic Stimulation
Action Potentials/drug effects/*physiology
Amifampridine
Animals
Biophysical Phenomena/drug effects
Calcium Channel Blockers/pharmacology
Calcium Channels
Calcium/metabolism
Excitatory Amino Acid Antagonists/pharmacology
Green David Brian
Grimsley Calum Alex
In Vitro Techniques
Inbred CBA
Inferior Colliculi/*cytology
Journal of neurophysiology
L-Type/*metabolism
Mice
Neurons/*physiology
Nimodipine/pharmacology
omega-Conotoxin GVIA/pharmacology
Potassium Channel Blockers/pharmacology
Quinoxalines/pharmacology
Sivaramakrishnan Shobhana
Wakefulness
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00634.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00634.2005</a>
Pages
88–105
Issue
1
Volume
95
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Auditory responses in the cochlear nucleus of awake mustached bats: precursors to spectral integration in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-01
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/*physiology; Animals; Auditory; Brain Mapping; Brain Stem/*physiology; Chiroptera/*physiology; Cochlear Nucleus/*physiology; Evoked Potentials; Mesencephalon/physiology; Nerve Net/*physiology; Pitch Perception/*physiology; Wakefulness/physiology
Creator
An entity primarily responsible for making the resource
Marsh Robert A; Nataraj Kiran; Gans Donald; Portfors Christine V; Wenstrup Jeffrey J
Description
An account of the resource
In the cochlear nucleus (CN) of awake mustached bats, single- and two-tone stimuli were used to examine how responses in major CN subdivisions contribute to spectrotemporal integrative features in the inferior colliculus (IC). Across CN subdivisions, the proportional representation of frequencies differed. A striking result was the substantial number of units tuned to frequencies \textless23 kHz. Across frequency bands, temporal response patterns, latency, and spontaneous discharge differed. For example, the 23- to 30-kHz representation, which comprises the fundamental of the sonar call, had an unusually high proportion of units with onset responses (39%) and low spontaneous rates (53%). Units tuned to 58-59 kHz, corresponding to the sharply tuned cochlear resonance, had slightly but significantly longer latencies than other bands. In units tuned to frequencies \textgreater30 kHz, 31% displayed a secondary excitatory peak, usually between 10 and 22 kHz. The secondary peak may originate in cochlear mechanisms for some units, but in others it may result from convergent input onto CN neurons. In 20% of units tested with two-tone stimuli, suppression of best frequency (BF) responses was tuned at least an octave below BF. These properties may underlie similar IC responses. However, other forms of spectral interaction present in IC were absent in CN: we found no facilitatory combination-sensitive interactions and very few combination-sensitive inhibitory interactions of the dominant IC type in which inhibition was tuned to 23-30 kHz. Such interactions arise above CN. Distinct forms of spectral integration thus originate at different levels of the ascending auditory pathway.
Identifier
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<a href="http://doi.org/10.1152/jn.00634.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.00634.2005</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Acoustic Stimulation/methods
Action Potentials/*physiology
Animals
Auditory
Brain Mapping
Brain Stem/*physiology
Chiroptera/*physiology
Cochlear Nucleus/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Evoked Potentials
Gans Donald
Journal of neurophysiology
Marsh Robert A
Mesencephalon/physiology
Nataraj Kiran
NEOMED College of Medicine
Nerve Net/*physiology
Pitch Perception/*physiology
Portfors Christine V
Wakefulness/physiology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00472.2014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00472.2014</a>
Pages
1819–1830
Issue
6
Volume
113
Dublin Core
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Title
A name given to the resource
A function for binaural integration in auditory grouping and segregation in the inferior colliculus.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-03
Subject
The topic of the resource
*Auditory Perception; Animals; Auditory; binaural integration; Evoked Potentials; Female; Guinea Pigs; harmonic complex; Inferior Colliculi/cytology/*physiology; inferior colliculus; Male; Neurons/physiology; pitch
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Shackleton Trevor M; Magezi David A; Palmer Alan R
Description
An account of the resource
Responses of neurons to binaural, harmonic complex stimuli in urethane-anesthetized guinea pig inferior colliculus (IC) are reported. To assess the binaural integration of harmonicity cues for sound segregation and grouping, responses were measured to harmonic complexes with different fundamental frequencies presented to each ear. Simultaneously gated harmonic stimuli with fundamental frequencies of 125 Hz and 145 Hz were presented to the left and right ears, respectively, and recordings made from 96 neurons with characteristic frequencies \textgreater2 kHz in the central nucleus of the IC. Of these units, 70 responded continuously throughout the stimulus and were excited by the stimulus at the contralateral ear. The stimulus at the ipsilateral ear excited (EE: 14%; 10/70), inhibited (EI: 33%; 23/70), or had no significant effect (EO: 53%; 37/70), defined by the effect on firing rate. The neurons phase locked to the temporal envelope at each ear to varying degrees depending on signal level. Many of the cells (predominantly EO) were dominated by the response to the contralateral stimulus. Another group (predominantly EI) synchronized to the contralateral stimulus and were suppressed by the ipsilateral stimulus in a phasic manner. A third group synchronized to the stimuli at both ears (predominantly EE). Finally, a group only responded when the waveform peaks from each ear coincided. We conclude that these groups of neurons represent different "streams" of information but exhibit modifications of the response rather than encoding a feature of the stimulus, like pitch.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00472.2014" target="_blank" rel="noreferrer noopener">10.1152/jn.00472.2014</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Auditory Perception
2015
Animals
Auditory
binaural integration
Evoked Potentials
Female
Guinea Pigs
harmonic complex
Inferior Colliculi/cytology/*physiology
inferior colliculus
Journal of neurophysiology
Magezi David A
Male
Nakamoto Kyle T
Neurons/physiology
Palmer Alan R
pitch
Shackleton Trevor M
-
Text
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URL Address
<a href="http://doi.org/10.1152/jn.00451.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00451.2009</a>
Pages
2050–2061
Issue
4
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-04
Subject
The topic of the resource
*Acoustic Stimulation; Action Potentials/physiology; Animal; Animals; Auditory Cortex/*physiology; Auditory Pathways/*physiology; Female; Guinea Pigs; Inferior Colliculi/*physiology; Male; Models; Pitch Perception/physiology
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Shackleton Trevor M; Palmer Alan R
Description
An account of the resource
One of the fundamental questions of auditory research is how sounds are segregated because, in natural environments, multiple sounds tend to occur at the same time. Concurrent sounds, such as two talkers, physically add together and arrive at the ear as a single input sound wave. The auditory system easily segregates this input into a coherent perception of each of the multiple sources. A common feature of speech and communication calls is their harmonic structure and in this report we used two harmonic complexes to study the role of the corticofugal pathway in the processing of concurrent sounds. We demonstrate that, in the inferior colliculus (IC) of the anesthetized guinea pig, deactivation of the auditory cortex altered the temporal and/or the spike response to the concurrent, monaural harmonic complexes. More specifically, deactivating the auditory cortex altered the representation of the relative level of the complexes. This suggests that the auditory cortex modulates the representation of the level of two harmonic complexes in the IC. Since sound level is a cue used in the segregation of auditory input, the corticofugal pathway may play a role in this segregation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00451.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00451.2009</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Acoustic Stimulation
2010
Action Potentials/physiology
Animal
Animals
Auditory Cortex/*physiology
Auditory Pathways/*physiology
Female
Guinea Pigs
Inferior Colliculi/*physiology
Journal of neurophysiology
Male
Models
Nakamoto Kyle T
Palmer Alan R
Pitch Perception/physiology
Shackleton Trevor M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00422.2011</a>
Pages
1047–1057
Issue
4
Volume
107
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel coding mechanism for social vocalizations in the lateral amygdala.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
The topic of the resource
*Social Behavior; Acoustic Stimulation; Action Potentials/*physiology; Amygdala/*cytology/physiology; Animal/*physiology; Animals; Auditory Pathways/*physiology; Chiroptera; Dextrans/metabolism; Echolocation/physiology; Female; Male; Neurons/*physiology; Reaction Time/physiology; Rhodamines/metabolism; Time Factors; Vocalization
Creator
An entity primarily responsible for making the resource
Gadziola Marie A; Grimsley Jasmine M S; Shanbhag Sharad J; Wenstrup Jeffrey J
Description
An account of the resource
The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed how neurons respond to and encode information that is carried within complex acoustic stimuli. We characterized responses of single neurons in the lateral nucleus of the amygdala to social vocalizations and synthetic acoustic stimuli in awake big brown bats. Neurons typically responded to most of the social vocalizations presented (mean = nine of 11 vocalizations) but differentially modulated both firing rate and response duration. Surprisingly, response duration provided substantially more information about vocalizations than did spike rate. In most neurons, variation in response duration depended, in part, on persistent excitatory discharge that extended beyond stimulus duration. Information in persistent firing duration was significantly greater than in spike rate, and the majority of neurons displayed more information in persistent firing, which was more likely to be observed in response to aggressive vocalizations (64%) than appeasement vocalizations (25%), suggesting that persistent firing may relate to the behavioral context of vocalizations. These findings suggest that the amygdala uses a novel coding strategy for discriminating among vocalizations and underscore the importance of persistent firing in the general functioning of the amygdala.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">10.1152/jn.00422.2011</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2012
Acoustic Stimulation
Action Potentials/*physiology
Amygdala/*cytology/physiology
Animal/*physiology
Animals
Auditory Pathways/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dextrans/metabolism
Echolocation/physiology
Female
Gadziola Marie A
Grimsley Jasmine M S
Journal of neurophysiology
Male
NEOMED College of Medicine
Neurons/*physiology
Reaction Time/physiology
Rhodamines/metabolism
Shanbhag Sharad J
Time Factors
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00419.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00419.2009</a>
Pages
1672–1683
Issue
3
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
Animals; Auditory Pathways/physiology; Biophysics; Brain Mapping; Chick Embryo; Cochlear Nucleus/*cytology; Electric Stimulation/methods; Excitatory Amino Acid Agents/pharmacology; GABA Agents/pharmacology; gamma-Aminobutyric Acid/*metabolism/pharmacology; In Vitro Techniques; Inhibitory Postsynaptic Potentials/drug effects/physiology; Nerve Net/*physiology; Neural Inhibition/drug effects/*physiology; Neurons/*physiology; Patch-Clamp Techniques/methods; Synaptic Transmission/drug effects/*physiology; Time Factors
Creator
An entity primarily responsible for making the resource
Tang Zheng-Quan; Gao Hongxiang; Lu Yong
Description
An account of the resource
Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus magnocellularis (NM) and GABAergic inhibition from the ipsilateral superior olivary nucleus. Here, we study metabotropic glutamate receptor (mGluR)- and GABAB receptor (GABABR)-mediated modulation of synaptic transmission in NL neurons. Gramicidin-perforated recordings from acute brain stem slice preparations showed that the reversal potential of the GABAergic responses in NL neurons was more depolarized than the spike threshold. Activation of the GABAergic input produced a mix of inhibitory and excitatory actions in NL neurons. The inhibitory action is known to be critical in improving the acuity of temporal processing of sounds. The excitatory action, however, would reduce the phase locking fidelity of NL neurons in response to their excitatory inputs from the NM. We show that activation of presynaptic mGluRs or GABABRs by either exogenous agonists or synaptically released neurotransmitters reduced the GABAergic responses, preventing the excitatory action of GABA while leaving the inhibitory action intact. Unlike most CNS synapses, the glutamatergic transmission in the NL was not modulated by either mGluRs or GABABRs, indicating that fixed (nonmodulatory) excitatory inputs to the NL may be optimal for coincidence detection. This study contributes to our understanding of how selective neuromodulation is achieved to suit a particular function of neuronal circuits in the brain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00419.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00419.2009</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Auditory Pathways/physiology
Biophysics
Brain Mapping
Chick Embryo
Cochlear Nucleus/*cytology
Department of Anatomy & Neurobiology
Electric Stimulation/methods
Excitatory Amino Acid Agents/pharmacology
GABA Agents/pharmacology
gamma-Aminobutyric Acid/*metabolism/pharmacology
Gao Hongxiang
In Vitro Techniques
Inhibitory Postsynaptic Potentials/drug effects/physiology
Journal of neurophysiology
Lu Yong
NEOMED College of Medicine
Nerve Net/*physiology
Neural Inhibition/drug effects/*physiology
Neurons/*physiology
Patch-Clamp Techniques/methods
Synaptic Transmission/drug effects/*physiology
Tang Zheng-Quan
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00227.2014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00227.2014</a>
Pages
683–704
Issue
3
Volume
112
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-08
Subject
The topic of the resource
Action Potentials/physiology; Animals; Antigens/metabolism; auditory midbrain; Calcium/metabolism; env/metabolism; Experimental/physiopathology; Gene Products; Hearing Loss/physiopathology; Inferior Colliculi/physiopathology/virology; inferior colliculus; Leukemia; Leukemia Virus; Membrane Potentials/physiology; Mice; Microglia/physiology/virology; Murine/*physiology; Neural Pathways/physiopathology; Neurodegenerative Diseases/*physiopathology; Neuroglia/physiology/virology; Neurons/*physiology/virology; Patch-Clamp Techniques; postinhibitory rebound neurons; Proteoglycans/metabolism; Retroviridae Infections/*physiopathology/virology; retrovirus; Tissue Culture Techniques; Tumor Virus Infections/*physiopathology/virology; Voltage-Sensitive Dye Imaging; voltage-sensitive dyes
Creator
An entity primarily responsible for making the resource
Li Ying; Davey Robert A; Sivaramakrishnan Shobhana; Lynch William P
Description
An account of the resource
Certain retroviruses induce progressive spongiform motor neuron disease with features resembling prion diseases and amyotrophic lateral sclerosis. With the neurovirulent murine leukemia virus (MLV) FrCasE, Env protein expression within glia leads to postsynaptic vacuolation, cellular effacement, and neuronal loss in the absence of neuroinflammation. To understand the physiological changes associated with MLV-induced spongiosis, and its neuronal specificity, we employed patch-clamp recordings and voltage-sensitive dye imaging in brain slices of the mouse inferior colliculus (IC), a midbrain nucleus that undergoes extensive spongiosis. IC neurons characterized by postinhibitory rebound firing (PIR) were selectively affected in FrCasE-infected mice. Coincident with Env expression in microglia and in glia characterized by NG2 proteoglycan expression (NG2 cells), rebound neurons (RNs) lost PIR, became hyperexcitable, and were reduced in number. PIR loss and hyperexcitability were reversed by raising internal calcium buffer concentrations in RNs. PIR-initiated rhythmic circuits were disrupted, and spontaneous synchronized bursting and prolonged depolarizations were widespread. Other IC neuron cell types and circuits within the same degenerative environment were unaffected. Antagonists of NMDA and/or AMPA receptors reduced burst firing in the IC but did not affect prolonged depolarizations. Antagonists of L-type calcium channels abolished both bursts and slow depolarizations. IC infection by the nonneurovirulent isogenic virus Friend 57E (Fr57E), whose Env protein is structurally similar to FrCasE, showed no RN hyperactivity or cell loss; however, PIR latency increased. These findings suggest that spongiform neurodegeneration arises from the unique excitability of RNs, their local regulation by glia, and the disruption of this relationship by glial expression of abnormal protein.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00227.2014" target="_blank" rel="noreferrer noopener">10.1152/jn.00227.2014</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Action Potentials/physiology
Animals
Antigens/metabolism
auditory midbrain
Calcium/metabolism
Davey Robert A
Department of Integrative Medical Sciences
env/metabolism
Experimental/physiopathology
Gene Products
Hearing Loss/physiopathology
Inferior Colliculi/physiopathology/virology
inferior colliculus
Journal of neurophysiology
Leukemia
Leukemia Virus
Li Ying
Lynch William P
Membrane Potentials/physiology
Mice
Microglia/physiology/virology
Murine/*physiology
NEOMED College of Medicine
Neural Pathways/physiopathology
Neurodegenerative Diseases/*physiopathology
Neuroglia/physiology/virology
Neurons/*physiology/virology
Patch-Clamp Techniques
postinhibitory rebound neurons
Proteoglycans/metabolism
Retroviridae Infections/*physiopathology/virology
retrovirus
Sivaramakrishnan Shobhana
Tissue Culture Techniques
Tumor Virus Infections/*physiopathology/virology
Voltage-Sensitive Dye Imaging
voltage-sensitive dyes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00114.2018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00114.2018</a>
Pages
1558–1571
Issue
4
Volume
120
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Late maturation of backward masking in auditory cortex.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
auditory; cortex; detection; development; masking
Creator
An entity primarily responsible for making the resource
Mattingly Michelle M; Donell Brittany M; Rosen Merri J
Description
An account of the resource
Speech perception relies on the accurate resolution of brief, successive sounds that change rapidly over time. Deficits in the perception of such sounds, indicated by a reduced ability to detect signals during auditory backward masking, strongly relate to language processing difficulties in children. Backward masking during normal development has a longer maturational trajectory than many other auditory percepts, implicating the involvement of central auditory neural mechanisms with protracted developmental time courses. Despite the importance of this percept, its neural correlates are not well described at any developmental stage. We therefore measured auditory cortical responses to masked signals in juvenile and adult Mongolian gerbils and quantified the detection ability of individual neurons and neural populations in a manner comparable with psychoacoustic measurements. Perceptually, auditory backward masking manifests as higher thresholds for detection of a short signal followed by a masker than for the same signal in silence. Cortical masking was driven by a combination of suppressed responses to the signal and a reduced dynamic range available for signal detection in the presence of the masker. Both coding elements contributed to greater masked threshold shifts in juveniles compared with adults, but signal-evoked firing suppression was more pronounced in juveniles. Neural threshold shifts were a better match to human psychophysical threshold shifts when quantified with a longer temporal window that included the response to the delayed masker, suggesting that temporally selective listening may contribute to age-related differences in backward masking. NEW & NOTEWORTHY In children, auditory detection of backward masked signals is immature well into adolescence, and detection deficits correlate with problems in speech processing. Our auditory cortical recordings reveal immature backward masking in adolescent animals that mirrors the prolonged development seen in children. This is driven by both signal-evoked suppression and dynamic range reduction. An extended window of analysis suggests that differences in temporally focused listening may contribute to late maturing thresholds for backward masked signals.
Identifier
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<a href="http://doi.org/10.1152/jn.00114.2018" target="_blank" rel="noreferrer noopener">10.1152/jn.00114.2018</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Auditory
cortex
Department of Anatomy & Neurobiology
detection
development
Donell Brittany M
Journal of neurophysiology
masking
Mattingly Michelle M
NEOMED College of Medicine
Rosen Merri J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00056.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00056.2005</a>
Pages
314–326
Issue
1
Volume
94
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Leading inhibition to neural oscillation is important for time-domain processing in the auditory midbrain.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-07
Subject
The topic of the resource
*Periodicity; Acoustic Stimulation/methods; Action Potentials/drug effects/physiology; Animals; Anura; Auditory Pathways/physiology; Bicuculline/pharmacology; Chiroptera; Dose-Response Relationship; Echolocation/*physiology; GABA Antagonists/pharmacology; Mesencephalon/*cytology/physiology; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Newborn; Radiation; Reaction Time/drug effects/*physiology; Sound; Species Specificity; Time Factors
Creator
An entity primarily responsible for making the resource
Galazyuk Alexander V; Lin Wenyu; Llano Daniel; Feng Albert S
Description
An account of the resource
A number of central auditory neurons exhibit paradoxical latency shift (PLS), a response characterized by longer response latencies at higher sound levels. PLS neurons are known to play a role in target ranging for echolocating bats that emit frequency-modulated sounds. We recently reported that early inhibition of unit's oscillatory discharges is critical for PLS in the inferior colliculus (IC) of little brown bats. The goal of this study was to determine in echolocating bats and in non-echolocating animals (frogs): 1) the detailed characteristics of PLS and whether PLS was dependent on sound level, frequency, and duration; 2) the time course of inhibition underlying PLS using a paired-pulse paradigm. We found that 22% of IC neurons in bats and 15% in frogs exhibited periodic discharge patterns in response to tone pulses at high sound levels. The firing periodicity was unit specific and independent of sound level and duration. Other IC neurons (28% in bats; 14% in frogs) exhibited PLS. These PLS neurons shared several response characteristics: 1) PLS was largely independent of sound frequency and 2) the magnitude of shift in first-spike latency was either duration dependent or duration tolerant. For PLS neurons, application of bicuculline abolished PLS and unmasked the unit's periodical firing pattern that served as the building block for PLS. In response to paired sound pulses, PLS neurons exhibited delay-dependent response suppression, confirming that high-threshold leading inhibition was responsible for PLS. Results also revealed the timing of excitatory and inhibitory inputs underlying PLS and its role in time-domain processing.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00056.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.00056.2005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Periodicity
2005
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Anura
Auditory Pathways/physiology
Bicuculline/pharmacology
Chiroptera
Department of Anatomy & Neurobiology
Dose-Response Relationship
Echolocation/*physiology
Feng Albert S
GABA Antagonists/pharmacology
Galazyuk Alexander V
Journal of neurophysiology
Lin Wenyu
Llano Daniel
Mesencephalon/*cytology/physiology
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Newborn
Radiation
Reaction Time/drug effects/*physiology
Sound
Species Specificity
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00040.2009</a>
Pages
1004–1016
Issue
2
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycinergic inhibition creates a form of auditory spectral integration in nuclei of the lateral lemniscus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects; Animals; Auditory Perception/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; GABA Antagonists/pharmacology; GABA-A Receptor Antagonists; GABA-A/metabolism; gamma-Aminobutyric Acid/metabolism; Glycine Agents/pharmacology; Glycine/*physiology; Glycine/antagonists & inhibitors/metabolism; Microelectrodes; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Nataraj Kiran; Wenstrup Jeffrey
Description
An account of the resource
For analyses of complex sounds, many neurons integrate information across different spectral elements via suppressive effects that are distant from the neurons' excitatory tuning. In the mustached bat, suppression evoked by sounds within the first sonar harmonic (23-30 kHz) or in the subsonar band (\textless23 kHz) alters responsiveness to the higher best frequencies of many neurons. This study examined features and mechanisms associated with low-frequency (LF) suppression among neurons of the lateral lemniscal nuclei (NLL). We obtained extracellular recordings from neurons in the intermediate and ventral nuclei of the lateral lemniscus, observing different forms of LF suppression related to the two above-cited frequency bands. To understand the mechanisms underlying this suppression in NLL neurons, we examined the roles of glycinergic and GABAergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (GlyRs), or bicuculline, an antagonist to gamma-aminobutyric acid type A receptors (GABA(A)Rs). With blockade of GABA(A)Rs, neurons showed an increase in firing rate to best frequency (BF) and/or LF tones but retained LF suppression of BF sounds. For neurons that displayed LF suppression tuned to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00040.2009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Acoustic Stimulation
Action Potentials/drug effects
Animals
Auditory Perception/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
GABA Antagonists/pharmacology
GABA-A Receptor Antagonists
GABA-A/metabolism
gamma-Aminobutyric Acid/metabolism
Glycine Agents/pharmacology
Glycine/*physiology
Glycine/antagonists & inhibitors/metabolism
Journal of neurophysiology
Microelectrodes
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Peterson Diana Coomes
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey