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<a href="http://doi.org/10.14309/01.ajg.0000706532.82398.af" target="_blank" rel="noreferrer noopener">http://doi.org/10.14309/01.ajg.0000706532.82398.af</a>
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Pages
S564-S565
Issue
S
Volume
115
ISSN
0002-9270
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Role of Markers of Heavy Metal Metabolism in Identification of Hepatic Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)
Date
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2020
2020-10
Subject
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Oxidative stress; hepatic fibrosis; non-alcoholic fatty liver disease; Heavy Metals; non-alcoholic steatohepatitis (NASH)
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Aggarwal Manik;Mitchell B;Singh AD;Kasumov T;McCullough A
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INTRODUCTION: Fibrosis & nonalcoholic steatohepatitis (NASH) are important predictors of long term prognosis in patients with non-alcoholic fatty liver disease (NAFLD). Oxidative stress (OS) has been shown to play a central role in progression of NAFLD, & changes in proteins associated with metal homeostasis may exacerbate OS. We investigated relationship of proteins related to transition metal metabolism with fibrosis in NAFLD. METHODS: Adult patients (>18y) who underwent liver biopsy for clinically suspected NAFLD at our institution were included. We retrospectively collected serum levels of ceruloplasmin (Cp), ferritin, iron, & transferrin saturation (Tsat) within 3 months of liver biopsy & calculated Cp/Tsat ratio (CT ratio) & Cp/Ferritin ratio (CF ratio). Histologic features were scored by an experienced pathologist using Non-alcoholic Steatohepatitis Clinical Research Network criteria. Fibrosis was staged as (0 - 4). Independent T test were used to compare the means & receiver operating characteristics (ROC) curves were plotted for assessing area under curve (AUC), sensitivity (Sn) & specificity (Sp). RESULTS: 174 patients were included in final analysis. The mean age of subjects was 48 y. Baseline features are depicted in Table 1. Biopsy proven NASH was seen in 61.5% of liver biopsies. No fibrosis was seen in 29.3% of liver biopsies & Stage 1, 2,3& 4 fibrosis were seen in 29.9%, 10.9%, 14.3% & 15.55% of samples. Mean Tsat was significantly higher (24.41% v/s 38.27%, P < 0.0001) & Cp (mg/dl) (27.82 v/s 24.91, P = 0.03) significantly lower between patients with advanced fibrosis (AF) (3-4) v/s early fibrosis (EF) (0-2). The mean CT ratio was also higher in patients with EF v/s AF (1.54 v/s 1.02, P = 0.01). The mean Tsat of patients with fibrosis v/s without fibrosis was higher (31.4% v/s 21.57% P < 0.005) however mean Cp (mg/dl) values were not significantly different (27.88 v/s 27.58, P = 0.42). The ROC curves show CF ratio (Figure 1) at a cut off of 0.10 had AUC = 0.61 (Sn = 70%, Sp = 52% P = 0.01) to detect any fibrosis & CT ratio (Figure 2) at a cut off 0.86 had AUC = 0.65 (Sn = 69%, Sp = 50% P = 0.002) for differentiating EF v/s AF. CONCLUSION: Our data reveals changes in ceruloplasmin: transferrin system, which decreases the content of toxic ions of Fe2+ in NAFLD. Tsat, Cp, CF ratio & CT ratio are useful non-invasive biomarkers in identifying NAFLD patients with fibrosis. Markers of heavy metal metabolism can spare patients from liver biopsies & can be potential therapeutic targets in future.
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<a href="http://doi.org/10.14309/01.ajg.0000706532.82398.af" target="_blank" rel="noreferrer noopener">10.14309/01.ajg.0000706532.82398.af</a>
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journalArticle
Publisher
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American Journal Of Gastroenterology
2020
Aggarwal Manik
American Journal of Gastroenterology
Department of Pharmaceutical Sciences
February 2021 List
Heavy Metals
hepatic fibrosis
journalArticle
Kasumov T
McCullough A
Mitchell B
NEOMED College of Pharmacy
non-alcoholic steatohepatitis (NASH)
Non-alcoholic Fatty Liver Disease
Oxidative Stress
Singh AD
-
Text
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<a href="http://doi.org/10.1016/j.ab.2020.114067" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ab.2020.114067</a>
Pages
114067
Volume
615
ISSN
1096-0309 0003-2697
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Measuring acetyl-coa and acetylated histone turnover in vivo: Effect of a high fat diet.
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Analytical Biochemistry
Date
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2021
2021-02-15
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Acetyl-CoA; Acetylation; Heavy water; High resolution mass spectrometry; Histone; Turnover
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Arias-Alvarado A; Aghayev M; Ilchenko S; Rachdaoui N; Lepp J; Tsai T-H; Zhang G-F; Previs S; Kasumov T
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Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for simultaneous measurement of acetyl-CoA and acetylated histones kinetics using a single (2)H(2)O tracer, and used it to examine effect of HFD-induced perturbations on hepatic histone acetylation in LDLR(-/-) mice, a mouse model of non-alcoholic fatty liver disease (NAFLD). Mice were given (2)H(2)O in the drinking water and the kinetics of hepatic acetyl-CoA, histones, and acetylated histones were quantified based on their (2)H-labeling. Consumption of a high fat Western-diet (WD) for twelve weeks led to decreased acetylation of hepatic histones (p< 0.05), as compared to a control diet. These changes were associated with 1.5-3-fold increased turnover rates of histones without any change in acetyl-CoA flux. Acetylation significantly reduced the stability of histones and the turnover rates of acetylated peptides were correlated with the number of acetyl groups in neighboring lysine sites. We conclude that (2)H(2)O-method can be used to study metabolically controlled histone acetylation and acetylated histone turnover in vivo.
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<a href="http://doi.org/10.1016/j.ab.2020.114067" target="_blank" rel="noreferrer noopener">10.1016/j.ab.2020.114067</a>
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journalArticle
2021
Acetyl-CoA
Acetylation
Aghayev M
Analytical biochemistry
Arias-Alvarado A
Department of Pharmaceutical Sciences
Heavy water
High resolution mass spectrometry
Histone
Ilchenko S
January 2021 List
journalArticle
Kasumov T
Lepp J
NEOMED College of Pharmacy
Previs S
Rachdaoui N
Tsai T-H
Turnover
Zhang G-F
-
Text
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<a href="http://doi.org/10.3390/metabo10110474" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/metabo10110474</a>
Issue
11
Volume
10
ISSN
2218-1989 2218-1989 2218-1989
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Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of (2)H-Labeling of Small Molecules.
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Metabolites
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11-20
Subject
The topic of the resource
stable isotopes; data integration; gas chromatography-mass spectrometry; isotope fractionation; metabolic flux; Savitzky-Golay
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Downes DP; Kasumov T; Daurio NA; Wood NB; Previs MJ; Sheth PR; McLaren DG; Previs SF
Description
An account of the resource
Stable isotope tracers can be used to quantify the activity of metabolic pathways. Specifically, (2)H-water is quite versatile, and its incorporation into various products can enable measurements of carbohydrate, lipid, protein and nucleic acid kinetics. However, since there are limits on how much (2)H-water can be administered and since some metabolic processes may be slow, it is possible that one may be challenged with measuring small changes in isotopic enrichment. We demonstrate an advantage of the isotope fractionation that occurs during gas chromatography, namely, setting tightly bounded integration regions yields a powerful approach for determining isotope ratios. We determined how the degree of isotope fractionation, chromatographic peak width and mass spectrometer dwell time can increase the apparent isotope labeling. Relatively simple changes in the logic surrounding data acquisition and processing can enhance gas chromatography-mass spectrometry measures of low levels of (2)H-labeling, this is especially useful when asymmetrical peaks are recorded at low signal:background. Although we have largely focused attention on alanine (which is of interest in studies of protein synthesis), it should be possible to extend the concepts to other analytes and/or hardware configurations.
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<a href="http://doi.org/10.3390/metabo10110474" target="_blank" rel="noreferrer noopener">10.3390/metabo10110474</a>
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journalArticle
2020
data integration
Daurio NA
December 2020 List
Department of Pharmaceutical Sciences
Downes DP
gas chromatography-mass spectrometry
isotope fractionation
journalArticle
Kasumov T
McLaren DG
metabolic flux
metabolites
NEOMED College of Pharmacy
Previs MJ
Previs SF
Savitzky-Golay
Sheth PR
Stable isotopes
Wood NB
-
Text
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
324A
Issue
1
Volume
72
ISSN
0270-9139
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Title
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Effect of a high fat "western type" diet on dynamics of hepatic acetylated mitochondrial proteins in a mouse model of NAFLD
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
Creator
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Kasumov T;Arias-Alvarado A;Aghayev M;Ilchenko S;McCullough AJ
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Aghayev M
Arias-Alvarado A
Department of Pharmaceutical Sciences
Hepatology
Ilchenko S
journalArticle
Kasumov T
McCullough AJ
NEOMED College of Pharmacy
October 2020 List
-
Text
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URL Address
<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/ijms21207472</a>
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Issue
20
Volume
21
ISSN
1422-0067 1422-0067
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Department of Pharmacy Practice
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Title
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Early pro-inflammatory remodeling of HDL proteome in a model of diet-induced obesity: 2H2O-metabolic labeling-based kinetic approach.
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International Journal of Molecular Sciences
Date
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2020
2020-10-10
Subject
The topic of the resource
inflammation; NAFLD; proteome dynamics; dyslipidemia; insulin resistance; diet-induced obesity; acute-phase proteins; high-density lipoprotein; high-fat diet
Creator
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Sadana P;Lin Li;Aghayev M;Ilchenko S;Kasumov T
Description
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Mice fed a high-fat diet for 12 weeks or longer develop hyperglycemia, insulin resistance, dyslipidemia, and fatty liver. Additionally, a high-fat diet induces inflammation that remodels and affects the anti-inflammatory and antiatherogenic property of the high-density lipoprotein (HDL). However, the precise time course of metabolic disease progression and HDL remodeling remains unclear. Short-term (four weeks) high-fat feeding (60% fat calories) was performed in wild-type male C57BL/6J mice to gain insights into the early metabolic disease processes in conjunction with a HDL proteome dynamics analysis using a heavy water metabolic labeling approach. The high-fat diet-fed mice developed hyperglycemia, impaired glucose tolerance, hypercholesterolemia without hypertriglyceridemia or hepatic steatosis. A plasma HDL proteome dynamics analysis revealed increased turnover rates (and reduced half-lives) of several acute-phase response proteins involved in innate immunity, including complement C3 (12.77 ± 0.81 vs. 9.98 ± 1.20 h, p < 0.005), complement factor B (12.71 ± 1.01 vs. 10.85 ± 1.04 h, p < 0.05), complement Factor H (19.60 ± 1.84 vs. 16.80 ± 1.58 h, p < 0.05), and complement factor I (25.25 ± 1.29 vs. 19.88 ± 1.50 h, p < 0.005). Our findings suggest that an early immune response-induced inflammatory remodeling of the plasma HDL proteome precedes the diet-induced steatosis and dyslipidemia.
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<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">10.3390/ijms21207472</a>
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journalArticle
2020
acute-phase proteins
Aghayev M
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
diet-induced obesity
dyslipidemia
high-density lipoprotein
High-fat diet
Ilchenko S
Inflammation
Insulin Resistance
International journal of molecular sciences
journalArticle
Kasumov T
Lin Li
NAFLD
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
October 2020 List
Proteome dynamics
Sadana P
-
Text
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<a href="http://doi.org/10.1021/acschembio.0c00380" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acschembio.0c00380</a>
ISSN
1554-8937
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Title
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Examining targeted protein degradation from physiological and analytical perspectives: Enabling translation between cells and subjects.
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ACS Chemical Biology
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2020
2020-09-30
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Daurio NA;Zhou H;Chen Y;Sheth PR;Imbriglio JE;McLaren DG;Tawa P;Rachdaoui N;Previs MJ;Kasumov T;O'Neil J;Previs SF
Description
An account of the resource
The ability to target specific proteins for degradation may open a new door toward developing therapeutics. Although effort in chemistry is essential for advancing this modality, i.e., one needs to generate proteolysis targeting chimeras (bifunctional molecules, also referred to as PROTACS) or "molecular glues" to accelerate protein degradation, we suspect that investigations could also benefit by directing attention toward physiological regulation surrounding protein homeostasis, including the methods that can be used to examine changes in protein kinetics. This perspective will first consider some metabolic scenarios that might be of importance when one aims to change protein abundance by increasing protein degradation. Specifically, could protein turnover impact the apparent outcome? We will then outline how to study protein dynamics by coupling stable isotope tracer methods with mass spectrometry-based detection; since the experimental conditions could have a dramatic effect on protein turnover, special attention is directed toward the application of methods for quantifying protein kinetics using in vitro and in vivo models. Our goal is to present key concepts that should enable mechanistically informed studies which test targeted protein degradation strategies.
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<a href="http://doi.org/10.1021/acschembio.0c00380" target="_blank" rel="noreferrer noopener">10.1021/acschembio.0c00380</a>
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journalArticle
2020
Acs Chemical Biology
Chen Y
Daurio NA
Department of Pharmaceutical Sciences
Imbriglio JE
journalArticle
Kasumov T
McLaren DG
NEOMED College of Pharmacy
O'Neil J
Previs MJ
Previs SF
Rachdaoui N
September 2020 List
Sheth PR
Tawa P
Zhou H
-
Text
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URL Address
<a href="http://doi.org/10.1021/acs.jproteome.6b00601" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acs.jproteome.6b00601</a>
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Pages
3388-3404
Issue
9
Volume
15
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Proteome Dynamics Reveals Pro-inflammatory Remodeling Of Plasma Proteome In A Mouse Model Of Nafld
Publisher
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Journal of Proteome Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
antiinflammatory properties; Atherosclerosis; Biochemistry & Molecular Biology; fatty liver-disease; gene-expression; HDL; heavy water; high-density-lipoprotein; mass-spectrometry; NAFLD; oxidized phospholipids; ppar-alpha; proteome dynamics; proteomics; rapid method; shotgun; statistical-model
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Li L; Bebek G; Previs S F; Smith J D; Sadygov R G; McCullough A J; Willard B; Kasumov T
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Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease. Because the liver is the major source of circulatory proteins, it is not surprising that hepatic disease could lead to alterations in the plasma proteome, which are therein implicated in atherosclerosis. The current study used low-density lipoprotein receptor-deficient (LDLR-/-) mice to examine the impact of Western diet (WD)-induced NAFLD on plasma proteome homeostasis. Using a (H2O)-H-2-metabolic labeling method, we found that a WD led to a proinflammatory distribution of circulatory proteins analyzed in apoB-depleted plasma, which was attributed to an increased production. The fractional turnover rates of short-lived proteins that are implicated in stress-response, lipid metabolism, and transport functions were significantly increased with WD (P < 0.05). Pathway analyses revealed that alterations in plasma proteome dynamics were related to the suppression of hepatic PPAR alpha, which was confirmed based on reduced gene and protein expression of PPAR alpha in mice fed a WD. These changes were associated with similar to 4-fold increase (P < 0.0001) in the proinflammatory property of apoB-depleted plasma. In conclusion, the proteome dynamics method reveals proinflammatory remodeling of the plasma proteome relevant to liver disease. The approach used herein may provide a useful metric of in vivo liver function and better enable studies of novel therapies surrounding NAFLD and other diseases.
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<a href="http://doi.org/10.1021/acs.jproteome.6b00601" target="_blank" rel="noreferrer noopener">10.1021/acs.jproteome.6b00601</a>
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The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2016
antiinflammatory properties
Atherosclerosis
Bebek G
Biochemistry & Molecular Biology
Department of Pharmaceutical Sciences
fatty liver-disease
gene-expression
HDL
Heavy water
high-density-lipoprotein
Journal Article or Conference Abstract Publication
Journal of proteome research
Kasumov T
Li L
Mass-spectrometry
McCullough A J
NAFLD
NEOMED College of Pharmacy
oxidized phospholipids
PPAR-alpha
Previs S F
Proteome dynamics
proteomics
rapid method
Sadygov R G
shotgun
Smith J D
statistical-model
Willard B
-
Text
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URL Address
<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/osp4.309</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36-45
Issue
1
Volume
5
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Title
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A Systematic Review: The Appraisal Of The Effects Of Metformin On Lipoprotein Modification And Function
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Obesity Science & Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
a-i; cardiovascular-disease; cholesterol; Endocrinology & Metabolism; expression; glycation end-products; Gycation; high-density-lipoprotein; increases; Lipoproteins; metformin; methylglyoxal; oxidative stress; Type II diabetes; type-2
Creator
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Kheniser K G; Kashyap S R; Kasumov T
Description
An account of the resource
Aims Metformin is a commonly prescribed anti-hyperglycaemic pharmacological agent, and it remains a staple in the management of type II diabetes. In addition to metformin's glucose lowering effects, research has indicated that metformin inhibits glycation-mediated and oxidative modification of lipoprotein residues. The purpose was to discuss the effects of metformin as it relates to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) modification. Materials and methods The purpose was to conduct a narrative and pragmatic review on the effects of metformin as it pertains to HDL and LDL modification. Results High-density lipoprotein (HDL) concentration is a quantitative measure and therefore does not provide insight into its function, which is a qualitative property. Dysfunctional HDLs are unable to carry out functions normally associated with HDL because they can be modified by glycating agents. Metformin may counteract HDL dysfunction by abating HDL modification. Reductions in HDL modification may improve reverse cholesterol transport ability and thus possibly diminish cardiovascular risk. Similarly, metformin-mediated attenuations in LDL modification may reduce their atherogenic potency. Conclusion Metformin may partially ameliorate HDL dysfunction and reduce LDL modification by inhibiting alpha-dicarbonyl-mediated modification of apolipoprotein residues; consequently, the results are salient because cardiovascular disease incidence may be reduced given that reverse cholesterol transport activity predicts risk, and modified LDL are proatherogenic.
Identifier
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<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">10.1002/osp4.309</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2019
a-i
cardiovascular-disease
Cholesterol
Department of Pharmaceutical Sciences
Endocrinology & Metabolism
expression
glycation end-products
Gycation
high-density-lipoprotein
increases
Journal Article or Conference Abstract Publication
Kashyap S R
Kasumov T
Kheniser K G
Lipoproteins
metformin
methylglyoxal
NEOMED College of Pharmacy
Obesity science & practice
Oxidative Stress
Type II diabetes
type-2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1082A-1083A
Volume
66
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Transferrin And Ceruloplasmin Kinetics Discriminate Simple Steatosis From Nonalcoholic Steatohepatitis
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Kasumov T; Lee K; Osme A; Kalinina I; Dasarathy J; Dasarathy S; McCullough A J
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Dasarathy J
Dasarathy S
Department of Pharmaceutical Sciences
Gastroenterology & Hepatology
Hepatology
Journal Article or Conference Abstract Publication
Kalinina I
Kasumov T
Lee K
McCullough A J
NEOMED College of Pharmacy
Osme A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
614A-614A
Volume
64
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Proteome Dynamics Reveals That High Density Lipoprotein Dysfunction In Nonalcoholic Steatohepatitis Is Related To Increased Degradation Of Hdl Proteins Involved In Reverse Cholesterol Transport
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Kasumov T; Lee K; Osme A; Dasarathy J; Li L; Willard B; Kalinina I; Dasarathy S; Smith J D; McCullough A J
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2016
Dasarathy J
Dasarathy S
Department of Pharmaceutical Sciences
Gastroenterology & Hepatology
Hepatology
Journal Article or Conference Abstract Publication
Kalinina I
Kasumov T
Lee K
Li L
McCullough A J
NEOMED College of Pharmacy
Osme A
Smith J D
Willard B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
37
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Title
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The Role Of Amadori-glycation In High Density Lipoprotein Dysfunction And Oxidative Stress In Patients With Diabetes
Publisher
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Arteriosclerosis Thrombosis and Vascular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Apolipoproteins; Atherosclerosis; Cardiovascular System & Cardiology; Hematology; Insulin resistance
Creator
An entity primarily responsible for making the resource
Kasumov T; Golizeh M; Lee K; Ilchenko S; Wang S H; Smith J; Kashyap S
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Apolipoproteins
Arteriosclerosis Thrombosis and Vascular Biology
Atherosclerosis
Cardiovascular System & Cardiology
Department of Pharmaceutical Sciences
Golizeh M
Hematology
Ilchenko S
Insulin Resistance
Journal Article or Conference Abstract Publication
Kashyap S
Kasumov T
Lee K
NEOMED College of Pharmacy
Smith J
Wang S H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
500A-501A
Volume
68
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Title
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Hyperammonemia Induced Redox Changes In Skeletal Muscle Perturbs Glucose-pyruvate Metabolism And Tissue Bioenergetics
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
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Gangadhariah M; Allawy A; Davuluri G; Kumar A; Kant S; Alchirazi K A; Shah R; Sandlers Y; Kasumov T; Mao X; O'Connell T; Harris R; Dasarathy S
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n/a
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Journal Article or Conference Abstract Publication
2018
Alchirazi K A
Allawy A
Dasarathy S
Davuluri G
Department of Pharmaceutical Sciences
Gangadhariah M
Gastroenterology & Hepatology
Harris R
Hepatology
Kant S
Kasumov T
Kumar A
Mao X
NEOMED College of Pharmacy
O'Connell T
Sandlers Y
Shah R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1328A-1329A
Volume
68
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Title
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Dyslipidemia Alters HDL Metabolism and Function in NAFLD
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
McCullough A J; Kim C; Osme A; Lee K; Dasarathy J; Dasarathy S; Kasumov T
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2018
Dasarathy J
Dasarathy S
Department of Pharmaceutical Sciences
Gastroenterology & Hepatology
Hepatology
Journal Article or Conference Abstract Publication
Kasumov T
Kim C
Lee K
McCullough A J
NEOMED College of Pharmacy
Osme A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/acs.jproteorne.8b00417" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/acs.jproteorne.8b00417</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3740-3748
Issue
11
Volume
17
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Title
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d2ome, Software for in Vivo Protein Turnover Analysis Using Heavy Water Labeling and LC-MS, Reveals Alterations of Hepatic Proteome Dynamics in a Mouse Model of NAFLD
Publisher
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Journal of Proteome Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-11
Subject
The topic of the resource
40S ribosomal proteins; algorithm; amino-acids; Biochemistry & Molecular Biology; dna; in vivo protein turnover; isotopomer; Mass spectrometry; metabolic labeling; NAFLD; nonlinear least-squares modeling; peak detection and integration; proliferation; protein half-life; proteome dynamics; proteostasis; quantification; rates; respiratory-chain; steatosis; UPR
Creator
An entity primarily responsible for making the resource
Sadygov R G; Avva J; Rahman M; Lee K; Ilchenko S; Kasumov T; Borzou A
Description
An account of the resource
Metabolic labeling with heavy water followed by LC-MS is a high throughput approach to study proteostasis in vivo. Advances in mass spectrometry and sample processing have allowed consistent detection of thousands of proteins at multiple time points. However, freely available automated bioinformatics tools to analyze and extract protein decay rate constants are lacking. Here, we describe d2ome-a robust, automated software solution for in vivo protein turnover analysis. d2ome is highly scalable, uses innovative approaches to nonlinear fitting, implements Grubbs' outlier detection and removal, uses weighted-averaging of replicates, applies a data dependent elution time windowing, and uses mass accuracy in peak detection. Here, we discuss the application of d2ome in a comparative study of protein turnover in the livers of normal vs Western diet-fed LDLR-/- mice (mouse model of nonalcoholic fatty liver disease), which contained 256 LC-MS experiments. The study revealed reduced stability of 40S ribosomal protein subunits in the Western diet-fed mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/acs.jproteorne.8b00417" target="_blank" rel="noreferrer noopener">10.1021/acs.jproteorne.8b00417</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2018
40S ribosomal proteins
algorithm
amino-acids
Avva J
Biochemistry & Molecular Biology
Borzou A
Department of Pharmaceutical Sciences
DNA
Ilchenko S
in vivo protein turnover
isotopomer
Journal Article
Journal of proteome research
Kasumov T
Lee K
Mass spectrometry
metabolic labeling
NAFLD
NEOMED College of Pharmacy
nonlinear least-squares modeling
peak detection and integration
proliferation
protein half-life
Proteome dynamics
proteostasis
quantification
Rahman M
rates
respiratory-chain
Sadygov R G
Steatosis
UPR
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/osp4.309</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36-45
Issue
1
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A systematic review: the appraisal of the effects of metformin on lipoprotein modification and function.
Publisher
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Obesity science & practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
Lipoproteins; Type II diabetes; Gycation; Metformin
Creator
An entity primarily responsible for making the resource
Kheniser K G; Kashyap S R; Kasumov T
Description
An account of the resource
Aims: Metformin is a commonly prescribed anti-hyperglycaemic pharmacological agent, and it remains a staple in the management of type II diabetes. In addition to metformin's glucose lowering effects, research has indicated that metformin inhibits glycation-mediated and oxidative modification of lipoprotein residues. The purpose was to discuss the effects of metformin as it relates to high-density lipoprotein (HDL) and low-density lipoprotein (LDL) modification. Materials and methods: The purpose was to conduct a narrative and pragmatic review on the effects of metformin as it pertains to HDL and LDL modification. Results: High-density lipoprotein (HDL) concentration is a quantitative measure and therefore does not provide insight into its function, which is a qualitative property. Dysfunctional HDLs are unable to carry out functions normally associated with HDL because they can be modified by glycating agents. Metformin may counteract HDL dysfunction by abating HDL modification. Reductions in HDL modification may improve reverse cholesterol transport ability and thus possibly diminish cardiovascular risk. Similarly, metformin-mediated attenuations in LDL modification may reduce their atherogenic potency. Conclusion: Metformin may partially ameliorate HDL dysfunction and reduce LDL modification by inhibiting alpha-dicarbonyl-mediated modification of apolipoprotein residues; consequently, the results are salient because cardiovascular disease incidence may be reduced given that reverse cholesterol transport activity predicts risk, and modified LDL are proatherogenic.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/osp4.309" target="_blank" rel="noreferrer noopener">10.1002/osp4.309</a>
2019
Department of Pharmaceutical Sciences
Gycation
Kashyap S R
Kasumov T
Kheniser K G
Lipoproteins
metformin
NEOMED College of Pharmacy
Obesity science & practice
Type II diabetes