1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciw247" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciw247</a>
Pages
532–538
Issue
4
Volume
63
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Approaches to Modifying the Behavior of Clinicians Who Are Noncompliant With Antimicrobial Stewardship Program Guidelines.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-08
Subject
The topic of the resource
*antibiotic stewardship; *Antimicrobial Stewardship; *ASP; *outlier physicians; *peer review; *Practice Patterns; Anti-Bacterial Agents/*therapeutic use; Communication; Evidence-Based Medicine; Guideline Adherence; Humans; Physicians; Physicians'; Practice Guidelines as Topic
Creator
An entity primarily responsible for making the resource
Goldstein Ellie J C; Goff Debra A; Reeve William; Naumovski Snezana; Epson Erin; Zenilman Jonathan; Kaye Keith S; File Thomas M Jr
Description
An account of the resource
Antimicrobial stewardship programs (ASPs) are a key national initiative to promote appropriate use of antibiotics and to reduce the burden of resistance. The dilemma of managing the outlier physician is especially complex. We outline strategies to establish a successful ASP that reviews appropriate efforts to achieve the goal of modifying outlier physicians' behavior. One must try to differentiate deviation from ASP norms from all other issues of outliers. Essential elements include identifying and understanding the local problems, planning, and achieving hospital administration and medical staff support. A successful ASP includes effective communication and acceptance of evidence-based recommendations, so that patient clinical outcomes will be optimized.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciw247" target="_blank" rel="noreferrer noopener">10.1093/cid/ciw247</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*antibiotic stewardship
*Antimicrobial stewardship
*ASP
*outlier physicians
*peer review
*Practice Patterns
2016
Anti-Bacterial Agents/*therapeutic use
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Communication
Department of Internal Medicine
Epson Erin
Evidence-Based Medicine
File Thomas M Jr
Goff Debra A
Goldstein Ellie J C
Guideline Adherence
Humans
Kaye Keith S
Naumovski Snezana
NEOMED College of Medicine
Physicians
Physicians'
Practice Guidelines as Topic
Reeve William
Zenilman Jonathan
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciw805" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciw805</a>
Pages
711–718
Issue
6
Volume
64
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
*beta-Lactam Resistance; *carbapenem-resistant Enterobacteriaceae; *colistin; *Klebsiella pneumoniae; *mortality; *ST258; Aged; Anti-Bacterial Agents/pharmacology/*therapeutic use; beta-Lactamases/genetics; Carbapenems/pharmacology/therapeutic use; Colistin/pharmacology/*therapeutic use; Comorbidity; Female; Humans; Kaplan-Meier Estimate; Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality; Klebsiella pneumoniae/classification/*drug effects/genetics; Male; Microbial Sensitivity Tests; Middle Aged; Phylogeny; Proportional Hazards Models
Creator
An entity primarily responsible for making the resource
Rojas Laura J; Salim Madiha; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Marshall Steve; Rudin Susan D; Domitrovic T Nicholas; Hujer Andrea M; Hujer Kristine M; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David
Description
An account of the resource
Background: Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide. Methods: A cohort nested within the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRACKLE) was constructed of patients with infection, or colonization with CRKp isolates tested for colistin susceptibility during the study period of December, 2011 to October, 2014. Reference colistin resistance determination as performed by broth macrodilution was compared to results from clinical microbiology laboratories (Etest) and to polymyxin resistance testing. Each patient was included once, at the time of their first colistin-tested CRKp positive culture. Time to 30-day in-hospital all-cause mortality was evaluated by Kaplan-Meier curves and Cox proportional hazard modeling. Results: In 246 patients with CRKp, 13% possessed ColR CRKp. ColR was underestimated by Etest (very major error rate = 35%, major error rate = 0.4%). A variety of rep-PCR strain types were encountered in both the ColS and the ColR groups. Carbapenem resistance was mediated primarily by blaKPC-2 (46%) and blaKPC-3 (50%). ColR was associated with increased hazard for in-hospital mortality (aHR 3.48; 95% confidence interval, 1.73-6.57; P \textless .001). The plasmid-associated ColR genes, mcr-1 and mcr-2 were not detected in any of the ColR CRKp. Conclusions: In this cohort, 13% of patients with CRKp presented with ColR CRKp. The apparent polyclonal nature of the isolates suggests de novo emergence of ColR in this cohort as the primary factor driving ColR. Importantly, mortality was increased in patients with ColR isolates.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciw805" target="_blank" rel="noreferrer noopener">10.1093/cid/ciw805</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*beta-Lactam Resistance
*carbapenem-resistant Enterobacteriaceae
*Colistin
*Klebsiella pneumoniae
*mortality
*ST258
2017
Aged
Anti-Bacterial Agents/pharmacology/*therapeutic use
beta-Lactamases/genetics
Bonomo Robert A
Carbapenems/pharmacology/therapeutic use
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Cober Eric
Colistin/pharmacology/*therapeutic use
Comorbidity
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Female
Fowler Vance G Jr
Hujer Andrea M
Hujer Kristine M
Humans
Kalayjian Robert C
Kaplan-Meier Estimate
Kaye Keith S
Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality
Klebsiella pneumoniae/classification/*drug effects/genetics
Male
Marshall Steve
Microbial Sensitivity Tests
Middle Aged
NEOMED College of Medicine
Perez Federico
Phylogeny
Proportional Hazards Models
Richter Sandra S
Rojas Laura J
Rudin Susan D
Salata Robert A
Salim Madiha
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/cix783" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/cix783</a>
Pages
163–171
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
benefit-risk; carbapenem-resistant Enterobacteriaceae; Carbapenems; Ceftazidime – Therapeutic Use; ceftazidime-avibactam; colistin; Colistin – Therapeutic Use; Comparative Studies; Drug Resistance; Enterobacteriaceae Infections – Drug Therapy; Human; In Vitro Studies; Klebsiella Infections; Klebsiella pneumoniae
Creator
An entity primarily responsible for making the resource
van Duin David; Lok Judith J; Earley Michelle; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Fowler Vance G Jr; Paterson David L; Bonomo Robert A; Evans Scott
Description
An account of the resource
Background: The efficacy of ceftazidime-avibactam-a cephalosporin-beta-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE)-compared with colistin remains unknown. Methods: Patients initially treated with either ceftazidime-avibactam or colistin for CRE infections were selected from the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), a prospective, multicenter, observational study. Efficacy, safety, and benefit-risk analyses were performed using intent-to-treat analyses with partial credit and the desirability of outcome ranking approaches. The ordinal efficacy outcome was based on disposition at day 30 after starting treatment (home vs not home but not observed to die in the hospital vs hospital death). All analyses were adjusted for confounding using inverse probability of treatment weighting (IPTW). Results: Thirty-eight patients were treated first with ceftazidime-avibactam and 99 with colistin. Most patients received additional anti-CRE agents as part of their treatment. Bloodstream (n = 63; 46%) and respiratory (n = 30; 22%) infections were most common. In patients treated with ceftazidime-avibactam versus colistin, IPTW-adjusted all-cause hospital mortality 30 days after starting treatment was 9% versus 32%, respectively (difference, 23%; 95% bootstrap confidence interval, 9%-35%; P = .001). In an analysis of disposition at 30 days, patients treated with ceftazidime-avibactam, compared with those treated within colistin, had an IPTW-adjusted probability of a better outcome of 64% (95% confidence interval, 57%-71%). Partial credit analyses indicated uniform superiority of ceftazidime-avibactam to colistin. Conclusions: Ceftazidime-avibactam may be a reasonable alternative to colistin in the treatment of K. pneumoniae carbapenemase-producing CRE infections. These findings require confirmation in a randomized controlled trial.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/cix783" target="_blank" rel="noreferrer noopener">10.1093/cid/cix783</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
benefit-risk
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Carbapenems
Ceftazidime – Therapeutic Use
ceftazidime-avibactam
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Cober Eric
colistin
Colistin – Therapeutic Use
Comparative Studies
Department of Internal Medicine
Doi Yohei
Drug Resistance
Earley Michelle
Enterobacteriaceae Infections – Drug Therapy
Evans Scott
Fowler Vance G Jr
Human
In Vitro Studies
Kalayjian Robert C
Kaye Keith S
Klebsiella Infections
Klebsiella pneumoniae
Lok Judith J
NEOMED College of Medicine
Paterson David L
Perez Federico
Richter Sandra S
Salata Robert A
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofx157" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofx157</a>
Pages
ofx157–ofx157
Issue
3
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-7
Subject
The topic of the resource
carbapenem-resistant Enterobacteriaceae; Klebsiella pneumoniae; ST258; surgical site infections; wound infection
Creator
An entity primarily responsible for making the resource
Henig Oryan; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Marshall Steve; Rudin Susan D; Domitrovic T Nicholas; Hujer Andrea M; Hujer Kristine M; Doi Yohei; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David; Kaye Keith S
Description
An account of the resource
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed. Molecular typing of isolates was performed using repetitive extragenic palindromic polymerase chain reaction (PCR). Carbapenemase genes were detected using PCR. RESULTS: One hundred forty-two patients were included: 62 had SSTI (44%) and 56% were colonized. Mean age was 61 years, and 48% were male: median Charlson score was 3 (interquartile range, 1-5). Forty-eight percent of patients were admitted from long-term care facilities (LTCFs), and 31% were from the community. Two strain types (ST258A and ST258B) were identified (73% of 45 tested). Carbapenemase genes were detected in 40 of 45 isolates (blaKPC-3 [47%], blaKPC-2 [42%]). Sixty-eight patients (48%) underwent surgical intervention, 63% of whom had SSTI. Patients admitted from LTCFs were less likely to undergo surgical intervention (odds ratio [OR], 0.36; 95% confidence interval [CI], 0.18-0.71). In multivariable analysis, among patients with SSTI, those admitted from LTCFs were less likely to undergo debridement (OR, 0.18; 95% CI, 0.04-0.93). CONCLUSIONS: Patients admitted from LTCFs with CRE SSTI were less likely to undergo surgical intervention. Sixteen percent of the patients died, and approximately 50% of survivors required more intensive care upon discharge. These findings suggest a unique, impactful syndrome within the CRE infection spectrum. Further studies are needed to assess the role of surgical debridement in management of CRE-SSTI, particularly among LTCF residents.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofx157" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofx157</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Fowler Vance G Jr
Henig Oryan
Hujer Andrea M
Hujer Kristine M
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumoniae
Marshall Steve
NEOMED College of Medicine
Open forum infectious diseases
Perez Federico
Richter Sandra S
Rudin Susan D
Salata Robert A
ST258
surgical site infections
van Duin David
Watkins Richard R
wound infection
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofx216" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofx216</a>
Pages
ofx216–ofx216
Issue
4
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Carbapenem-Resistant Enterobacteriaceae Infections in Patients on Renal Replacement Therapy.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-07
Subject
The topic of the resource
carbapenem-resistant Enterobacteriaceae; Klebsiella pneumoniae; mortality; renal failure; renal replacement therapy
Creator
An entity primarily responsible for making the resource
Eilertson Brandon; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; DeHovitz Jack; Kreiswirth Barry; van Duin David
Description
An account of the resource
Background: Patients on chronic intermittent renal replacement therapy (RRT) are at risk for infection with carbapenem-resistant Enterobacteriaceae (CRE). However, the impact of RRT on outcomes after CRE infections remains to be defined. Here we perform a comparison of outcomes for CRE-infected patients with preserved renal function compared with CRE-infected patients on RRT. Methods: Cases and controls were defined from a prospective cohort of CRE-infected patients from the Consortium on Resistance against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE). Cases were defined as CRE-infected patients on RRT at hospital admission, while controls were defined as CRE-infected patients with serum creatinine \textless2 mg/dL and not receiving RRT at admission. Risk factors for 28-day in-hospital mortality were assessed using multivariable logistic regression. An ordinal ranking of outcomes by desirability analysis was performed. Results: Patients on RRT were more likely to have diabetes mellitus and cardiac disease than controls. Urinary sources of infection were less common in the RRT group. In RRT patients, 28-day in-hospital mortality was increased as compared with controls: 22/71 (31%) vs 33/295 (11%). RRT remained significantly associated with 28-day in-hospital mortality after adjustment for source of infection, prehospitalization origin, and severity of illness (adjusted odds ratio, 2.27; 95% confidence interval [CI], 1.09-4.68; P = .03). Using univariable desirability of outcome ranking analysis, RRT status was associated with a 68% (95% CI, 61%-74%) chance of a worse disposition outcome. Conclusions: Chronic RRT in CRE-infected patients is associated with increased in-hospital mortality and worse disposition outcomes at 28 days.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofx216" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofx216</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Cober Eric
DeHovitz Jack
Department of Internal Medicine
Doi Yohei
Eilertson Brandon
Evans Scott
Fowler Vance G Jr
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumoniae
Kreiswirth Barry
Mortality
NEOMED College of Medicine
Open forum infectious diseases
Perez Federico
Renal failure
renal replacement therapy
Richter Sandra S
Salata Robert A
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
Pages
ofy351–ofy351
Issue
1
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
antimicrobial resistance; carbapenem-resistant Enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
An entity primarily responsible for making the resource
Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David
Description
An account of the resource
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Fowler Vance G Jr
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciz528" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciz528</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
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Title
A name given to the resource
The Pitt Bacteremia Score Predicts Mortality in Non-Bacteremic Infections.
Publisher
An entity responsible for making the resource available
Clinical Infectious Diseases: An Official Publication Of The Infectious Diseases Society Of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Creator
An entity primarily responsible for making the resource
Henderson Heather; Luterbach Courtney L; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Harris Anthony; Napravnik Sonia; van Duin David
Description
An account of the resource
Background: Predicting mortality risk in patients is important in research settings. The Pitt bacteremia score (PBS) is commonly used as a predictor of early mortality risk in patients with bloodstream infections (BSI). Here, we determined whether the PBS predicts 14-day inpatient mortality in non-bacteremia carbapenem-resistant Enterobacteriaceae (CRE) infections.; Methods: Patients were selected from the Consortium on resistance against carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE-1), a prospective, multicenter, observational study. We estimated risk ratios to analyze the predictive ability of the PBS overall and each of its components individually. We analyzed each component of the PBS in the prediction of mortality, assessed the appropriate cutoff value for the dichotomized score, and compared the predictive ability of the qPitt score to that of the PBS.; Results: In a cohort of 475 patients with CRE infections, a PBS ≥ 4 was associated with mortality in patients with non-bacteremia infections (RR=21.9 [95% CI: 7.0, 68.8]) and with BSI (RR=6.0 [95% CI: 2.5, 14.4]). In multivariable analysis, the hypotension, mechanical ventilation, mental status, and cardiac arrest parameters of the PBS were independent risk factors for 14-day all-cause inpatient mortality. The temperature parameter as originally calculated for the PBS was not independently associated with mortality. However, a temperature < 36.0ᴼ C versus ≥ 36ᴼ C was independently associated with mortality. A qPitt score ≥ 2 had similar discrimination as a PBS ≥ 4 in non-bacteremia infections.; Conclusion: Here, we validated that the PBS and qPitt score can be used as reliable predictors of mortality in non-bacteremia CRE infections.; © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciz528" target="_blank" rel="noreferrer noopener">10.1093/cid/ciz528</a>
2019
Bonomo Robert A
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Cober Eric
Department of Family & Community Medicine
Department of Internal Medicine
Doi Yohei
Evans Scott
Fowler Vance G
Harris Anthony
Henderson Heather
Kalayjian Robert C
Kaye Keith S
Luterbach Courtney L
Napravnik Sonia
NEOMED College of Medicine
Richter Sandra S
Salata Robert A
September 2019 Update
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciz816" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciz816</a>
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas Aeruginosa
Publisher
An entity responsible for making the resource available
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-09
Subject
The topic of the resource
aminoglycoside; ceftolozane; multidrug resistant; polymyxin; Pseudomonas
October 2019 Update
Creator
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Pogue Jason M; Kaye Keith S; Veve Michael P; Patel Twisha S; Gerlach Anthony T; Davis Susan L; Puzniak Laura A; File Tom M; Olson Shannon; Dhar Sorabh; Bonomo Robert A; Perez Federico
Description
An account of the resource
BACKGROUND: Ceftolozane/tazobactam is a novel cephalosporin/beta-lactamase inhibitor combination that often retains activity against resistant Pseudomonas aeruginosa. The comparative safety and efficacy vs polymyxins or aminoglycosides in this setting remains unknown. METHODS: A retrospective, multicenter, observational cohort study was performed. Patients who received ceftolozane/tazobactam were compared with those treated with either polymyxin or aminoglycoside-based regimens for infections due to drug-resistant P. aeruginosa. Multivariate logistic regression was performed controlling for factors associated with treatment to assess the independent impact of ceftolozane/tazobactam on clinical cure, acute kidney injury (AKI), and in-hospital mortality. RESULTS: A total of 200 patients were included (100 in each treatment arm). The cohort represented an ill population with 69% in the intensive care unit, 63% mechanically ventilated, and 42% in severe sepsis or septic shock at infection onset. The most common infection type was ventilator-associated pneumonia (52%); 7% of patients were bacteremic. Combination therapy was more commonly used in polymyxin/aminoglycoside patients than those who received ceftolozane/tazobactam (72% vs 15%, P < .001). After adjusting for differences between groups, receipt of ceftolozane/tazobactam was independently associated with clinical cure (adjusted odds ratio [aOR], 2.63; 95% confidence interval [CI], 1.31-5.30) and protective against AKI (aOR, 0.08; 95% CI, 0.03-0.22). There was no difference in in-hospital mortality. The number needed to treat for a clinical cure with ceftolozane/tazobactam was 5, and the number needed to harm with AKI with a polymyxin/aminoglycoside was 4. CONCLUSIONS: These data support the preferential use of ceftolozane/tazobactam over polymyxins or aminoglycosides for drug-resistant P. aeruginosa infections.
Identifier
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<a href="http://doi.org/10.1093/cid/ciz816" target="_blank" rel="noreferrer noopener">10.1093/cid/ciz816</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
aminoglycoside
Bonomo Robert A
ceftolozane
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Davis Susan L
Department of Internal Medicine
Dhar Sorabh
File Tom M
Gerlach Anthony T
Kaye Keith S
multidrug resistant
NEOMED College of Medicine
October 2019 Update
Olson Shannon
Patel Twisha S
Perez Federico
Pogue Jason M
polymyxin
Pseudomonas
Puzniak Laura A
Veve Michael P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofz360.577" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofz360.577</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S246-S246
Volume
6
ISSN
23288957
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Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ofid/ofz360.577" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ofid/ofz360.577</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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Title
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508. Gentamicin Non-susceptibility is Associated with Persistence of Carbapenem-Resistant Klebsiella pneumoniae in the Urinary Tract.
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Open Forum Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10-02
Subject
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NORTH Carolina; hospital admission; bacteriuria; urine; laboratory; antimicrobial susceptibility; Klebsiella pneumonia; bacteriuria; CENTERS for Disease Control & Prevention (U.S.); urinary tract infections; URINARY organs; urinary tract; health care systems; disclosure; CENTERS for Disease Control & Prevention (U.S.); amikacin; antibiotic overuse; carbapenem resistance; carbapenem-resistant enterobacteriaceae; GENTAMICIN; gentamicin sulfate (usp); gentamicins; health care safety; Klebsiella pneumonia; midwestern united states; persistence; persistence; rales; signs and symptoms; trimethoprim-sulfamethoxazole combination; urinary tract infections; urine culture
Creator
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Luterbach Courtney L; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kaye Keith S; Doi Yohei; Watkins Richard R; Bonomo Robert A; Duin David van
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Background Urinary tract infection (UTI) is the most common clinical manifestation of carbapenem-resistant Klebsiella pneumoniae (CR Kp). Persistent CR Kp bacteriuria is associated with the spread of CR Kp and antibiotic overuse. Risk factors for persistent CR Kp bacteriuria are uncertain. Methods CRACKLE-1 was a multicenter, prospective study that included 960 patients with at least one carbapenem-resistant Enterobacteriaceae (CRE)-positive culture from December 2011 to June 2016 collected from 18 hospitals encompassing 8 healthcare systems in the Midwestern US and North Carolina. Patients with CR Kp bacteriuria who were discharged alive from index hospitalization were included in the current study, and sporadic (single positive CR Kp urine culture) and persistent (≥2 CR Kp urine cultures during independent hospital admissions occurring at least 2 days apart) cases were compared. Antibiotic susceptibility testing was performed by local laboratories. Amikacin, gentamicin (GENT), and trimethoprim/sulfamethoxazole were included in the analysis based on variance and frequency of testing. The CDC/National Healthcare Safety Network criteria for UTI were used. Results CR Kp was the most common CRE isolate (n = 869, prevalence 91%). In patients with CR Kp , 527 had CR Kp isolated from the urine (prevalence 61%, 95% CI 0.57, 0.64). Of these, 486 patients, of whom 129 (27%) were diagnosed with a UTI, were discharged alive. Notably, 135/486 (28%) patients with CR Kp bacteriuria were readmitted and yielded a second urine culture of CR Kp. Most patients with persistent bacteriuria, 99/135 (73%), were asymptomatic at initial admission. Of these patients, 20/99 (20%) were diagnosed with a UTI at second admission. In multivariable analysis, only GENT non-susceptibility was associated with an increased risk (adjusted OR 1.66, 95% CI 1.10–2.49) of persistent bacteriuria. Persistent bacteriuria was independent of GENT treatment during index hospitalization (GENT was used in 15% of patients). Conclusion Bacteriuria with GENT non-susceptible CR Kp strains was associated with persistent bacteriuria. As this was independent of GENT treatment, GENT resistance determinants may be co-transmitted along with traits that promote bacterial persistence in CR Kp. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR]
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<a href="http://doi.org/10.1093/ofid/ofz360.577" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofz360.577</a>
Format
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Journal Article
2019
amikacin
antibiotic overuse
antimicrobial susceptibility
bacteriuria
Bonomo Robert A
carbapenem resistance
carbapenem-resistant Enterobacteriaceae
CENTERS for Disease Control & Prevention (U.S.)
Cleveland Clinic Akron General Hospital
Cober Eric
Department of Internal Medicine
Disclosure
Doi Yohei
Duin David van
Gentamicin
gentamicin sulfate (usp)
gentamicins
health care safety
health care systems
Henderson Heather I
hospital admission
Journal Article
Kaye Keith S
Klebsiella pneumonia
Laboratory
Luterbach Courtney L
Midwestern United States
NEOMED College of Medicine
North Carolina
November 2019 Update
Open forum infectious diseases
Persistence
rales
Richter Sandra S
Salata Robert A
signs and symptoms
Trimethoprim-Sulfamethoxazole Combination
URINARY organs
urinary tract
Urinary Tract Infections
Urine
urine culture
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
N.PAG-N.PAG
Issue
1
Volume
6
ISSN
23288957
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ofid/ofy351</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
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Open Forum Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
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antimicrobial resistance; carbapenem-resistant enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
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Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Duin David van
Description
An account of the resource
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Clev eland Clinic Akron General Hosptial
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Duin David van
Evans Scott
Fowler Vance G
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Journal Article
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
November 2019 Update
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
Watkins Richard R