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Text
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URL Address
<a href="http://doi.org/10.1016/j.freeradbiomed.2017.02.041" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.freeradbiomed.2017.02.041</a>
Pages
288–301
Volume
106
Dublin Core
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Title
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Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
Publisher
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Free radical biology & medicine
Date
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2017
2017-05
Subject
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*ERK1/2; *Nrf2; *Osteoarthritis; *Redox; *Wogonin; Anti-Inflammatory Agents/administration & dosage; Chondrocytes/drug effects/pathology; Flavanones/*administration & dosage; Gene Expression Regulation/drug effects; Humans; Inflammation/*drug therapy/metabolism/pathology; Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism; MAP Kinase Signaling System/drug effects; Molecular Docking Simulation; NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism; Osteoarthritis/*drug therapy/metabolism/pathology; Protein Binding; Reactive Oxygen Species/metabolism; Signal Transduction/drug effects
Creator
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Khan Nazir M; Haseeb Abdul; Ansari Mohammad Y; Devarapalli Pratap; Haynie Sara; Haqqi Tariq M
Description
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Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis. Here, we evaluated the potential chondroprotective and anti-inflammatory effects of Wogonin, a naturally occurring flavonoid, in IL-1beta-stimulated human OA chondrocytes and cartilage explants. Wogonin completely suppressed the expression and production of inflammatory mediators including IL-6, COX-2, PGE2, iNOS and NO in
Identifier
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<a href="http://doi.org/10.1016/j.freeradbiomed.2017.02.041" target="_blank" rel="noreferrer noopener">10.1016/j.freeradbiomed.2017.02.041</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*ERK1/2
*Nrf2
*OSTEOARTHRITIS
*Redox
*Wogonin
2017
Ansari Mohammad Y
Anti-Inflammatory Agents/administration & dosage
Chondrocytes/drug effects/pathology
Department of Anatomy & Neurobiology
Devarapalli Pratap
Flavanones/*administration & dosage
Free radical biology & medicine
Gene Expression Regulation/drug effects
Haqqi Tariq M
Haseeb Abdul
Haynie Sara
Humans
Inflammation/*drug therapy/metabolism/pathology
Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism
Khan Nazir M
MAP Kinase Signaling System/drug effects
Molecular Docking Simulation
NEOMED College of Medicine
NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism
Osteoarthritis/*drug therapy/metabolism/pathology
Protein Binding
Reactive Oxygen Species/metabolism
Signal Transduction/drug effects