1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1163/156855500750198762" target="_blank" rel="noreferrer noopener">http://doi.org/10.1163/156855500750198762</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
113-122
Issue
1
Volume
3
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synthesis And Characterization Of Tubular Amphiphilic Networks With Controlled Pore Dimensions For Insulin Delivery
Publisher
An entity responsible for making the resource available
Designed Monomers and Polymers
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000
Subject
The topic of the resource
drug release; Polymer Science
Creator
An entity primarily responsible for making the resource
Kennedy J P; Fenyvesi G; Na S; Keszler B; Rosenthal K S
Description
An account of the resource
A convenient laboratory process for the preparation of thin-walled (similar to 0.02 cm) tubular amphiphilic membranes has been developed. The membranes are suitable for implantation and isolation of pancreatic islets from immune responses. The process involves the simultaneous free radical copolymerization/crosslinking of dimethyl acrylamide (DMAAm) and methacrylate ditelechelic polyisobutylene (MA-PIB-MA) in narrow-bore (similar to 4 mm inner diameter) glass tubes horizontally rotating in a thermostated oven. The pore sizes of the membranes can be controlled by the length, i.e. molecular weight, of the hydrophilic poly(dimethyl acrylamide) (PDMAAm) segment (M-c,M-hydrophilic). Pore sizes, M-c,M-hydrophilic's, and molecular weight cut-off (MWCO) ranges of designed amphiphilic membranes were characterized in terms of Stokes (or viscosity) radii (Rs) and the relationships between these parameters were evaluated. Membranes were designed to allow the rapid diffusion of molecules such as insulin (M-n = 5733 g/mol, R-s = 1.34 nm) but to be opaque to serum albumin (M-n > 66 000 g/mol, R-s > 3.62 nm) and larger proteins such as immunoglobulins. The diffusion coefficients (D) and permeabilities (P) of tubular and flat-sheet amphiphilic membranes have been compared and were found to be similar. Membrane pore size dimensions of the tubular devices were determined by the out-diffusion of commercially available protein markers of known molecular weights (M-n = 6500-66 000 g/mol) and dimensions (R-s = 1.50-3.62 nm). It was found that the minimum M-c,M-hydrophilic or R-s that still allows the diffusion of insulin is similar to 800 g/mol or similar to 1.34 nm, respectively, and that the maximum M-c,M-hydrophilic or R-s that prevents the ingress of antibodies is similar to 5000 g/mol or similar to 3.62 nm, respectively. According to diffusion experiments, the presence or absence of lightly crosslinked 1% calcium alginate does not affect the rate of diffusion of glucose and insulin through our tubules. These membranes are being used in vivo for encapsulating islet cells for implantation to correct type 1 diabetes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1163/156855500750198762" target="_blank" rel="noreferrer noopener">10.1163/156855500750198762</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
Designed Monomers and Polymers
Drug Release
Fenyvesi G
Journal Article or Conference Abstract Publication
Kennedy J P
Keszler B
Na S
Polymer Science
Rosenthal K S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
U410-U410
Volume
219
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Amphiphilic Gels With Controlled-mesh Dimensions For Insulin Delivery
Publisher
An entity responsible for making the resource available
Abstracts of Papers of the American Chemical Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-03
Subject
The topic of the resource
Chemistry
Creator
An entity primarily responsible for making the resource
Kennedy J P; Fenyvesi G; Na S; Keszler B; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
Abstracts of Papers of the American Chemical Society
Chemistry
Fenyvesi G
Journal Article or Conference Abstract Publication
Kennedy J P
Keszler B
Na S
Rosenthal K S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
290-299
Volume
833
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Amphiphilic Gels With Controlled Mesh Dimensions For Insulin Delivery
Publisher
An entity responsible for making the resource available
Polymer Gels: Fundamentals and Applications
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003
Subject
The topic of the resource
drug release; islets; methacrylate)-1-polyisobutylene; networks; xenotransplantation
Creator
An entity primarily responsible for making the resource
Kennedy J P; Fenyvesi G; Na S; Keszler B; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2003
Book Chapter
Drug Release
Fenyvesi G
islets
Kennedy J P
Keszler B
methacrylate)-1-polyisobutylene
Na S
networks
Polymer Gels: Fundamentals and Applications
Rosenthal K S
xenotransplantation