1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1148/radiol.14140567" target="_blank" rel="noreferrer noopener">http://doi.org/10.1148/radiol.14140567</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 280-289 Issue 1 Volume 275 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Prostate Cancer: Diagnostic Performance of Real-time Shear-Wave Elastography Publisher An entity responsible for making the resource available Radiology Date A point or period of time associated with an event in the lifecycle of the resource 2015 2015-04 Subject The topic of the resource ultrasound; guidelines; ultrasonography; Radiology; elasticity; Nuclear Medicine & Medical Imaging; localization; risk; predictors; radical prostatectomy; biopsy; contrast-enhanced mri Creator An entity primarily responsible for making the resource Correas J M; Tissier A M; Khairoune A; Vassiliu V; Mejean A; Helenon O; Memo R; Barr R G Description An account of the resource Purpose: To prospectively evaluate the performance of real-time ultrasonographic (US) shear-wave elastography (SWE) in the diagnosis of peripheral zone prostate cancer in patients with high and/or increasing prostate-specific antigen levels and/or abnormal digital rectal examination results. Materials and Methods: After signing an informed consent form, men referred for transrectal prostate biopsy were enrolled in this prospective HIPAA-compliant two-center study, which was conducted with institutional review board approval. Transrectal US SWE of the prostate was performed after a conventional transrectal US examination and immediately before US-guided 12-core sextant biopsy. For each sextant, the maximum SWE value was measured and matched to the pathologic results of that sextant biopsy. The diagnostic performance of SWE was assessed at both patient and sextant levels. The elasticity value maximizing the Youden index was used to derive sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: The elasticity values were matched to pathologic results for a total of 1040 peripheral zone sextants in 184 men. One hundred twenty-nine positive biopsy findings (size,. 3 mm; Gleason score,. 6) were identified in 68 patients. The sextant-level sensitivity, specificity, PPV, NPV, and area under the receiver operating characteristic curve for SWE with a cutoff of 35 kPa for differentiating benign from malignant lesions were 96% (95% confidence interval [CI]: 95%, 97%), 85% (95% CI: 83%, 87%), 48% (95% CI: 46%, 50%), 99% (95% CI: 98%, 100%), and 95% (95% CI: 93%, 97%), respectively. Conclusion: Use of a 35-kPa threshold at SWE may provide additional information for the detection and biopsy guidance of prostate cancer, enabling a substantial reduction in the number of biopsies while ensuring that few peripheral zone adenocarcinomas are missed. (C) RSNA, 2014 Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1148/radiol.14140567" target="_blank" rel="noreferrer noopener">10.1148/radiol.14140567</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 2015 Barr R G Biopsy contrast-enhanced mri Correas J M Elasticity guidelines Helenon O Journal Article or Conference Abstract Publication Khairoune A localization Mejean A Memo R Nuclear Medicine & Medical Imaging predictors radical prostatectomy Radiology Risk Tissier A M Ultrasonography Ultrasound Vassiliu V