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A Neofunctionalized Gene Zcchc5 Is Expressed In Cartilage And Its Downregulation Inhibits Col2a1 Expression And Enhances The Expression Of Mmp-13 In Chondrocytes

A Wogonin-rich Fraction of scutellaria baicalensis Root Extract Exerts Chondroprotective Effects by Suppressing il-1β-induced Activation of AP-1 in Human OA Chondrocytes.

Elimination of dysfunctional mitochondria by parkin suppresses oxidative stress and expression of osteoarthritis related genes in human chondrocytes.

Human Chondrocytes With Oxidative And Er Stress Inhibit Protein Synthesis By Induction Of Trna Fragments From A Subset Of Trna Isotypes Independent Of Angiogenin Expression And Activity

LIN28A IS OVEREXPRESSED IN OSTEOARTHRITIS AND IS ESSENTIAL FOR THE STABILITY AND HIGH LEVEL EXPRESSION OF IL-6 AND COX-2 IN HUMAN CHONDROCYTES

Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.

OBJECTIVE: Mitochondrial dysfunction, oxidative stress and chondrocyte death are important contributors to the development and pathogenesis of osteoarthritis (OA). In this study, we determined the expression and role of Parkin in the clearance of…

Pleiotropic Roles Of Nrf2 As Regulators Of Chondrocyte Apoptosis, Oxidative Stress, Inflammatory Response And Catabolic And Anabolic Pathways In Osteoarthritis

Wogonin exerts anti-inflammatory effect by disrupting keap-1/Nrf2 interactions and activating Nrf2 in human OA chondrocytes.

Wogonin exerts anti-inflammatory effect by disrupting KEAP-1/NRF2 interactions and activating NRF2 in human OA chondrocytes.

ZCCHC6 (TUT7) DELETION INHIBIT THE EXPRESSION OF IL-6 AND MMP-13 AND REDUCES THE SEVERITY OF POST-TRAUMATIC OSTEOARTHRITIS IN A MURINE MODEL

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