1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1262-1265
Issue
8
Volume
88
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Barretts-esophagus - An Acquired Condition With Genetic Predisposition
Publisher
An entity responsible for making the resource available
American Journal of Gastroenterology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-08
Subject
The topic of the resource
adenocarcinoma; carcinoma; columnar epithelium; dysplasia; Gastroenterology & Hepatology; spectrum
Creator
An entity primarily responsible for making the resource
Fahmy N; King J F
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
Adenocarcinoma
American Journal of Gastroenterology
Carcinoma
columnar epithelium
Dysplasia
Fahmy N
Gastroenterology & Hepatology
King J F
spectrum
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/ajg.2009.241" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/ajg.2009.241</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1913-1921
Issue
8
Volume
104
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Assessment of Familiality, Obesity, and Other Risk Factors for Early Age of Cancer Diagnosis in Adenocarcinomas of the Esophagus and Gastroesophageal Junction
Publisher
An entity responsible for making the resource available
American Journal of Gastroenterology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-08
Subject
The topic of the resource
tobacco; alcohol; Gastroenterology & Hepatology; symptoms; body-mass index; abdominal obesity; barretts-esophagus; esophagogastric junction; gastric cardia; intestinal metaplasia; reflux disease
Creator
An entity primarily responsible for making the resource
Chak A; Falk G; Grady W M; Kinnard M; Elston R; Mittal S; King J F; Willis J E; Kondru A; Brock W; Barnholtz-Sloan J
Description
An account of the resource
OBJECTIVES: Adenocarcinomas of the esophagus and adenocarcinomas of the gastroesophageal junction are postulated to be complex genetic diseases. Combined influences of environmental factors and genetic susceptibility likely influence the age at which these cancers develop. The aim of this study was to determine whether familiality and other recognized risk factors are associated with the development of these cancers at an earlier age. METHODS: A structured validated questionnaire was utilized to collect self-reported data on gastroesophageal reflux symptoms, risk factors for Barrett's esophagus (BE) and family history, including age of cancer diagnosis in affected relatives from probands with BE, adenocarcinoma of the esophagus, or adenocarcinoma of the gastroesophageal junction, at five tertiary care academic hospitals. Medical records of all relatives reported to be affected were requested from hospitals providing this cancer care to confirm family histories. Familiality of BE/cancer, obesity (defined as body mass index >30), gastroesophageal reflux symptoms, and other risk factors were assessed for association with a young age of cancer diagnosis. RESULTS: A total of 356, 216 non-familial and 140 familial, cancers were studied. The study population consisted of 292 (82%) men and 64 (18%) women. Mean age of cancer diagnosis was no different in a comparison of familial and non-familial cancers, 62.6 vs. 61.9 years, P=0.70. There were also no significant differences in symptoms of gastroesophageal reflux, body mass index, race, gender, and smoking history between familial and non-familial cancers. Mean age of cancer diagnosis was significantly younger in those who were obese 1 year before diagnosis as compared to those who were non-obese, mean age 58.99 vs. 63.6 years, P=0.008. Multivariable modeling of age at cancer diagnosis showed that obesity 1 year before diagnosis was associated with a younger age of cancer diagnosis (P=0.005) after adjustment for heartburn and regurgitation duration. CONCLUSIONS: Obesity is associated with the development of esophageal and gastroesophageal junctional adenocarcinomas at an earlier age. Familial cancers arise at the same age as non-familial cancers and have a similar risk factor profile.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/ajg.2009.241" target="_blank" rel="noreferrer noopener">10.1038/ajg.2009.241</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
abdominal obesity
Alcohol
American Journal of Gastroenterology
Barnholtz-Sloan J
barretts-esophagus
body-mass index
Brock W
Chak A
Elston R
esophagogastric junction
Falk G
gastric cardia
Gastroenterology & Hepatology
Grady W M
intestinal metaplasia
Journal Article or Conference Abstract Publication
King J F
Kinnard M
Kondru A
Mittal S
reflux disease
Symptoms
tobacco
Willis J E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
1262–1265
Issue
8
Volume
88
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Barrett's esophagus: an acquired condition with genetic predisposition.
Publisher
An entity responsible for making the resource available
The American journal of gastroenterology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-08
Subject
The topic of the resource
Female; Humans; Male; Middle Aged; Aged; Biopsy; Pedigree; Adenocarcinoma/genetics; Barrett Esophagus/*genetics/pathology; Esophageal Neoplasms/genetics; Esophagus/pathology; Gastroesophageal Reflux/*genetics; Genes; Dominant
Creator
An entity primarily responsible for making the resource
Fahmy N; King J F
Description
An account of the resource
We describe four families with a strong familial expression of Barrett's/gastroesophageal reflux disease (GERD) complex spanning one to four generations with two to seven affected members per family. The purpose of this report is to highlight genetic trends in Barrett's esophagus, stress the importance of a family history in gastroesophageal reflux disease, and to call attention to unique features of familial Barrett's esophagus.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adenocarcinoma/genetics
Aged
Barrett Esophagus/*genetics/pathology
Biopsy
Dominant
Esophageal Neoplasms/genetics
Esophagus/pathology
Fahmy N
Female
Gastroesophageal Reflux/*genetics
Genes
Humans
King J F
Male
Middle Aged
Pedigree
The American journal of gastroenterology