1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofx216" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofx216</a>
Pages
ofx216–ofx216
Issue
4
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Carbapenem-Resistant Enterobacteriaceae Infections in Patients on Renal Replacement Therapy.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-07
Subject
The topic of the resource
carbapenem-resistant Enterobacteriaceae; Klebsiella pneumoniae; mortality; renal failure; renal replacement therapy
Creator
An entity primarily responsible for making the resource
Eilertson Brandon; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; DeHovitz Jack; Kreiswirth Barry; van Duin David
Description
An account of the resource
Background: Patients on chronic intermittent renal replacement therapy (RRT) are at risk for infection with carbapenem-resistant Enterobacteriaceae (CRE). However, the impact of RRT on outcomes after CRE infections remains to be defined. Here we perform a comparison of outcomes for CRE-infected patients with preserved renal function compared with CRE-infected patients on RRT. Methods: Cases and controls were defined from a prospective cohort of CRE-infected patients from the Consortium on Resistance against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE). Cases were defined as CRE-infected patients on RRT at hospital admission, while controls were defined as CRE-infected patients with serum creatinine \textless2 mg/dL and not receiving RRT at admission. Risk factors for 28-day in-hospital mortality were assessed using multivariable logistic regression. An ordinal ranking of outcomes by desirability analysis was performed. Results: Patients on RRT were more likely to have diabetes mellitus and cardiac disease than controls. Urinary sources of infection were less common in the RRT group. In RRT patients, 28-day in-hospital mortality was increased as compared with controls: 22/71 (31%) vs 33/295 (11%). RRT remained significantly associated with 28-day in-hospital mortality after adjustment for source of infection, prehospitalization origin, and severity of illness (adjusted odds ratio, 2.27; 95% confidence interval [CI], 1.09-4.68; P = .03). Using univariable desirability of outcome ranking analysis, RRT status was associated with a 68% (95% CI, 61%-74%) chance of a worse disposition outcome. Conclusions: Chronic RRT in CRE-infected patients is associated with increased in-hospital mortality and worse disposition outcomes at 28 days.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofx216" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofx216</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Cober Eric
DeHovitz Jack
Department of Internal Medicine
Doi Yohei
Eilertson Brandon
Evans Scott
Fowler Vance G Jr
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumoniae
Kreiswirth Barry
Mortality
NEOMED College of Medicine
Open forum infectious diseases
Perez Federico
Renal failure
renal replacement therapy
Richter Sandra S
Salata Robert A
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofx157" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofx157</a>
Pages
ofx157–ofx157
Issue
3
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
1905-7
Subject
The topic of the resource
carbapenem-resistant Enterobacteriaceae; Klebsiella pneumoniae; ST258; surgical site infections; wound infection
Creator
An entity primarily responsible for making the resource
Henig Oryan; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Marshall Steve; Rudin Susan D; Domitrovic T Nicholas; Hujer Andrea M; Hujer Kristine M; Doi Yohei; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David; Kaye Keith S
Description
An account of the resource
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed. Molecular typing of isolates was performed using repetitive extragenic palindromic polymerase chain reaction (PCR). Carbapenemase genes were detected using PCR. RESULTS: One hundred forty-two patients were included: 62 had SSTI (44%) and 56% were colonized. Mean age was 61 years, and 48% were male: median Charlson score was 3 (interquartile range, 1-5). Forty-eight percent of patients were admitted from long-term care facilities (LTCFs), and 31% were from the community. Two strain types (ST258A and ST258B) were identified (73% of 45 tested). Carbapenemase genes were detected in 40 of 45 isolates (blaKPC-3 [47%], blaKPC-2 [42%]). Sixty-eight patients (48%) underwent surgical intervention, 63% of whom had SSTI. Patients admitted from LTCFs were less likely to undergo surgical intervention (odds ratio [OR], 0.36; 95% confidence interval [CI], 0.18-0.71). In multivariable analysis, among patients with SSTI, those admitted from LTCFs were less likely to undergo debridement (OR, 0.18; 95% CI, 0.04-0.93). CONCLUSIONS: Patients admitted from LTCFs with CRE SSTI were less likely to undergo surgical intervention. Sixteen percent of the patients died, and approximately 50% of survivors required more intensive care upon discharge. These findings suggest a unique, impactful syndrome within the CRE infection spectrum. Further studies are needed to assess the role of surgical debridement in management of CRE-SSTI, particularly among LTCF residents.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofx157" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofx157</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Fowler Vance G Jr
Henig Oryan
Hujer Andrea M
Hujer Kristine M
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumoniae
Marshall Steve
NEOMED College of Medicine
Open forum infectious diseases
Perez Federico
Richter Sandra S
Rudin Susan D
Salata Robert A
ST258
surgical site infections
van Duin David
Watkins Richard R
wound infection
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/cix783" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/cix783</a>
Pages
163–171
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
benefit-risk; carbapenem-resistant Enterobacteriaceae; Carbapenems; Ceftazidime – Therapeutic Use; ceftazidime-avibactam; colistin; Colistin – Therapeutic Use; Comparative Studies; Drug Resistance; Enterobacteriaceae Infections – Drug Therapy; Human; In Vitro Studies; Klebsiella Infections; Klebsiella pneumoniae
Creator
An entity primarily responsible for making the resource
van Duin David; Lok Judith J; Earley Michelle; Cober Eric; Richter Sandra S; Perez Federico; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Fowler Vance G Jr; Paterson David L; Bonomo Robert A; Evans Scott
Description
An account of the resource
Background: The efficacy of ceftazidime-avibactam-a cephalosporin-beta-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE)-compared with colistin remains unknown. Methods: Patients initially treated with either ceftazidime-avibactam or colistin for CRE infections were selected from the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), a prospective, multicenter, observational study. Efficacy, safety, and benefit-risk analyses were performed using intent-to-treat analyses with partial credit and the desirability of outcome ranking approaches. The ordinal efficacy outcome was based on disposition at day 30 after starting treatment (home vs not home but not observed to die in the hospital vs hospital death). All analyses were adjusted for confounding using inverse probability of treatment weighting (IPTW). Results: Thirty-eight patients were treated first with ceftazidime-avibactam and 99 with colistin. Most patients received additional anti-CRE agents as part of their treatment. Bloodstream (n = 63; 46%) and respiratory (n = 30; 22%) infections were most common. In patients treated with ceftazidime-avibactam versus colistin, IPTW-adjusted all-cause hospital mortality 30 days after starting treatment was 9% versus 32%, respectively (difference, 23%; 95% bootstrap confidence interval, 9%-35%; P = .001). In an analysis of disposition at 30 days, patients treated with ceftazidime-avibactam, compared with those treated within colistin, had an IPTW-adjusted probability of a better outcome of 64% (95% confidence interval, 57%-71%). Partial credit analyses indicated uniform superiority of ceftazidime-avibactam to colistin. Conclusions: Ceftazidime-avibactam may be a reasonable alternative to colistin in the treatment of K. pneumoniae carbapenemase-producing CRE infections. These findings require confirmation in a randomized controlled trial.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/cix783" target="_blank" rel="noreferrer noopener">10.1093/cid/cix783</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
benefit-risk
Bonomo Robert A
carbapenem-resistant Enterobacteriaceae
Carbapenems
Ceftazidime – Therapeutic Use
ceftazidime-avibactam
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Cober Eric
colistin
Colistin – Therapeutic Use
Comparative Studies
Department of Internal Medicine
Doi Yohei
Drug Resistance
Earley Michelle
Enterobacteriaceae Infections – Drug Therapy
Evans Scott
Fowler Vance G Jr
Human
In Vitro Studies
Kalayjian Robert C
Kaye Keith S
Klebsiella Infections
Klebsiella pneumoniae
Lok Judith J
NEOMED College of Medicine
Paterson David L
Perez Federico
Richter Sandra S
Salata Robert A
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cmi.2016.01.023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cmi.2016.01.023</a>
Pages
513–519
Issue
6
Volume
22
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections.
Publisher
An entity responsible for making the resource available
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-06
Subject
The topic of the resource
*beta-Lactam Resistance; 80 and over; Aged; Bacteremia/microbiology/mortality; Bacterial/microbiology/mortality; carbapenem-resistant Enterobacteriaceae; epidemiology; Female; Humans; Klebsiella Infections/*microbiology/*mortality; Klebsiella pneumoniae; Klebsiella pneumoniae/*drug effects/isolation & purification; Longitudinal Studies; Male; Middle Aged; mortality; Mortality; pneumonia; Pneumonia; Prospective Studies; Survival Analysis; Urinary Tract Infections/microbiology/mortality
Creator
An entity primarily responsible for making the resource
Hauck C; Cober E; Richter S S; Perez F; Salata R A; Kalayjian R C; Watkins R R; Scalera N M; Doi Y; Kaye K S; Evans S; Fowler V G Jr; Bonomo R A; van Duin D
Description
An account of the resource
Patients infected or colonized with carbapenem-resistant Klebsiella pneumoniae (CRKp) are often chronically and acutely ill, which results in substantial mortality unrelated to infection. Therefore, estimating excess mortality due to CRKp infections is challenging. The Consortium on Resistance against Carbapenems in K. pneumoniae (CRACKLE) is a prospective multicenter study. Here, patients in CRACKLE were evaluated at the time of their first CRKp bloodstream infection (BSI), pneumonia or urinary tract infection (UTI). A control cohort of patients with CRKp urinary colonization without CRKp infection was constructed. Excess hospital mortality was defined as mortality in cases after subtracting mortality in controls. In addition, the adjusted hazard ratios (aHR) for time-to-hospital-mortality at 30 days associated with infection compared with colonization were calculated in Cox proportional hazard models. In the study period, 260 patients with CRKp infections were included in the BSI (90 patients), pneumonia (49 patients) and UTI (121 patients) groups, who were compared with 223 controls. All-cause hospital mortality in controls was 12%. Excess hospital mortality was 27% in both patients with BSI and those with pneumonia. Excess hospital mortality was not observed in patients with UTI. In multivariable analyses, BSI and pneumonia compared with controls were associated with aHR of 2.59 (95% CI 1.52-4.50, p \textless0.001) and 3.44 (95% CI 1.80-6.48, p \textless0.001), respectively. In conclusion, in patients with CRKp infection, pneumonia is associated with the highest excess hospital mortality. Patients with BSI have slightly lower excess hospital mortality rates, whereas excess hospital mortality was not observed in hospitalized patients with UTI.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cmi.2016.01.023" target="_blank" rel="noreferrer noopener">10.1016/j.cmi.2016.01.023</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*beta-Lactam Resistance
2016
80 and over
Aged
Bacteremia/microbiology/mortality
Bacterial/microbiology/mortality
Bonomo R A
carbapenem-resistant Enterobacteriaceae
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Cober E
Department of Internal Medicine
Doi Y
Epidemiology
Evans S
Female
Fowler V G Jr
Hauck C
Humans
Kalayjian R C
Kaye K S
Klebsiella Infections/*microbiology/*mortality
Klebsiella pneumoniae
Klebsiella pneumoniae/*drug effects/isolation & purification
Longitudinal Studies
Male
Middle Aged
Mortality
NEOMED College of Medicine
Perez F
Pneumonia
Prospective Studies
Richter S S
Salata R A
Scalera N M
Survival Analysis
Urinary Tract Infections/microbiology/mortality
van Duin D
Watkins R R