1
40
3
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Text
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URL Address
<a href="http://doi.org/10.1016/j.ekir.2020.03.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ekir.2020.03.025</a>
Pages
980-990
Issue
7
Volume
5
ISSN
2468-0249
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.ekir.2020.03.025" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.ekir.2020.03.025</a>
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Department of Anatomy & Neurobiology
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An overview of rickets in children
Publisher
An entity responsible for making the resource available
Kidney International Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07
Subject
The topic of the resource
prevention; vitamin D; mutations; animal-model; phosphate; chronic kidney disease; phosphorus; d-receptor; d-resistant rickets; hereditary hypophosphatemic rickets; hypocalcemia; hypophosphatemia; targeted ablation; vitamin-d-deficiency; x-linked hypophosphatemia
Creator
An entity primarily responsible for making the resource
Chanchlani R; Nemer P; Sinha R; Nemer L; Krishnappa V; Sochett E; Safadi F; Raina R
Description
An account of the resource
Rickets is a common bone disease worldwide that is associated with disturbances in calcium and phos- phate homeostasis and can lead to short stature and joint deformities. Rickets can be diagnosed based on history and physical examination, radiological features, and biochemical tests. It can be classified into 2 major groups based on phosphate or calcium levels: phosphopenic and calcipenic. Knowledge of cate- gorization of the type of rickets is essential for prompt diagnosis and proper management. Nutritional rickets is a preventable disease through adequate intake of vitamin D through both dietary and sunlight exposure. There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D- dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor -23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. An important development has been the introduction of burosumab, a human monoclonal antibody to FGF- 23, which is approved for the treatment of X -linked hypophosphatemia among children 1 year and older.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ekir.2020.03.025" target="_blank" rel="noreferrer noopener">10.1016/j.ekir.2020.03.025</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
animal-model
August 2020 List
Chanchlani R
Chronic kidney disease
d-receptor
d-resistant rickets
Department of Anatomy & Neurobiology
Department of Internal Medicine
hereditary hypophosphatemic rickets
hypocalcemia
hypophosphatemia
journalArticle
Kidney International Reports
Krishnappa V
mutations
Nemer L
Nemer P
NEOMED College of Medicine
NEOMED College of Medicine Student
phosphate
phosphorus
Prevention
Raina R
Safadi F
Sinha R
Sochett E
targeted ablation
Vitamin D
vitamin-d-deficiency
x-linked hypophosphatemia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/jch.13905" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/jch.13905</a>
Pages
1059–1069
Issue
6
Volume
22
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1111/jch.13905" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1111/jch.13905</a>
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Association of pulse pressure, pulse pressure index, and ambulatory arterial stiffness index with kidney function in a cross-sectional pediatric chronic kidney disease cohort from the CKiD study.
Publisher
An entity responsible for making the resource available
Journal of Clinical Hypertension
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06
Subject
The topic of the resource
inflammation; risk; children; blood-pressure; progression; ckd; AASI; chronic kidney disease; pulse pressure; pulse pressure index; aasi; albuminuria; dialysis patients; left-ventricular hypertrophy
Creator
An entity primarily responsible for making the resource
Raina R; Polaconda S; Nair N; Chakraborty R; Sethi S; Krishnappa V; Kapur G; Mhanna M; Kusumi K
Description
An account of the resource
The morbidity and mortality of adult and pediatric chronic kidney disease (CKD) and end-stage renal disease (ESRD) populations are mainly driven by cardiovascular disease (CVD). Improving CVD outcomes focuses on risk assessment of factors including diastolic blood pressure (DBP), systolic blood pressure (SBP), left ventricular mass index (LVMI), pulse pressure (PP), and pulse pressure index (PPi), which is calculated as PP/SBP. These markers are also proven predictors of CKD progression; however, their role in children has not been established. This study aims to evaluate the relationship between PP, PPi, ambulatory arterial stiffness index (AASI), and proteinuria with kidney function in pediatric CKD patients; it is a retrospective analysis of 620 patients (1-16 years) from the NIDDK Chronic Kidney Disease in Children (CKiD) registry. The authors analyzed data for three separate cohorts: an overall CKD as well as immunological versus non-immunological cause for CKD groups. An inverse relationship was found between SBP, DBP, and PP with iGFR and LVMI in the overall CKD group. Our immunological CKD subgroup showed significantly higher serum creatinine, SBP, DBP, and PP values with significantly lower serum albumin levels compared to the non-immunological group. There were no significant differences with iohexol-based glomerular filtration rate (iGFR), LVMI, PPi, or high-sensitivity C-reactive protein (hs-CRP) between the two groups. A subgroup analysis demonstrated that SBP, DBP, and PP all correlated significantly with LVMI in the immunological CKD patients but not the non-immunological subgroup. Additionally, AASI data in the overall CKD population were significantly correlated with PP, PPi, and DBP. This study is one of the first to correlate noninvasive measurements of vascular compliance including PP, PPi, and AASI with iGFR and LVMI in a pediatric CKD cohort. Improving our understanding of surrogate markers for early CVD is integral to improving the care of pediatric CKD population as these patients have yet to develop the hard end points of ESRD, heart failure, myocardial infarction, or stroke.
Identifier
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<a href="http://doi.org/10.1111/jch.13905" target="_blank" rel="noreferrer noopener">10.1111/jch.13905</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
AASI
albuminuria
blood-pressure
Chakraborty R
Children
Chronic kidney disease
ckd
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Dialysis Patients
Inflammation
Journal of Clinical Hypertension
journalArticle
July 2020 List
Kapur G
Krishnappa V
Kusumi K
left-ventricular hypertrophy
Mhanna M
Nair N
NEOMED College of Medicine
Polaconda S
progression
pulse pressure
pulse pressure index
Raina R
Risk
Sethi S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5414/cn109598" target="_blank" rel="noreferrer noopener">http://doi.org/10.5414/cn109598</a>
Pages
370–379
Issue
6
Volume
91
ISSN
0301-0430
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endothelin-1 as a therapeutic target in autosomal dominant polycystic kidney disease
Publisher
An entity responsible for making the resource available
Clinical Nephrology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
proliferation; hypertension; receptor; expression; Urology & Nephrology; growth-factor; renal damage; endothelin-1; excretion; polycystic kidney disease; chronic kidney disease; ADPKD; endothelin-1 antagonists; autosomal dominant; tolvaptan; urinary endothelin-1; water permeability
Creator
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Raina R; Chauvin A; Vajapey R; Khare A; Krishnappa V
Description
An account of the resource
Aims: Endothelin-1 (ET-1) is associated with the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD) via cyst progression. Elevated concentrations of ET-1 in ADPKD correlate with many phenotypic changes in the kidney such as renal cyst development, interstitial fibrosis, and glomerulosclerosis. In addition, an imbalance between renal ETA and ETB receptors possibly leads to more severe disease progression. The objective of this review is to determine whether evaluating the efficacy of these drugs in treatment of cystic kidney disease may be a worthwhile aim, as determined by results from animal and human models. Materials and methods: PubMed/Medline, Embase, and Google Scholar databases were searched using the key words "endothelin, endothelin-1 antagonists, and autosomal dominant polycystic kidney disease". All animal and human studies describing the effects of endothelin and endothelin-1 antagonists in ADPKD subjects were included in the review. Results: Urinary ET-1 concentrations could serve as a noninvasive surrogate biomarker for kidney ET-1 levels, as it is inversely associated with eGFR, independent of age, sex, and blood pressure. Elevated urinary excretion of ET-1 may be a biomarker for early renal injury. Antagonization of ET-1 may hopefully be a novel therapy for slowing progression of kidney damage in ADPKD. Conclusion: Based on the literature reviewed in this manuscript, it is proposed that further research evaluating the efficacy of endothelin antagonists in treatment of cystic kidney disease is warranted. More human studies need to be performed with larger sample sizes. Therefore, the recommendation for treatment is inconclusive at this time.
Identifier
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<a href="http://doi.org/10.5414/cn109598" target="_blank" rel="noreferrer noopener">10.5414/cn109598</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
ADPKD
Autosomal Dominant
Chauvin A
Chronic kidney disease
Clinical nephrology
Department of Internal Medicine
endothelin-1
endothelin-1 antagonists
excretion
expression
growth-factor
Hypertension
June 2019 Update
Khare A
Krishnappa V
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
polycystic kidney disease
proliferation
Raina R
Receptor
renal damage
Tolvaptan
urinary endothelin-1
Urology & Nephrology
Vajapey R
water permeability