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40
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Text
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URL Address
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/oncotarget.27583</a>
Pages
1876–1893
Issue
20
Volume
11
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.18632/oncotarget.27583</a>
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
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Title
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Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma.
Publisher
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Oncotarget
Date
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2020
2020-05
Subject
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DNA methylation; neuronatin; osteosarcoma; tumor suppressor genes
Creator
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Saeed H; Sinha S; Mella C; Kuerbitz JS; Cales ML; Steele MA; Stanke J; Damron D; Safadi F; Kuerbitz SJ
Description
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The paternally imprinted neuronatin (NNAT) gene has been identified as a target of aberrant epigenetic silencing in diverse cancers, but no association with pediatric bone cancers has been reported to date. In screening childhood cancers, we identified aberrant CpG island hypermethylation in a majority of osteosarcoma (OS) samples and in 5 of 6 human OS cell lines studied but not in normal bone-derived tissue samples. CpG island hypermethylation was associated with transcriptional silencing in human OS cells, and silencing was reversible upon treatment with
Identifier
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<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">10.18632/oncotarget.27583</a>
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journalArticle
2020
Cales ML
Damron D
Department of Anatomy & Neurobiology
Department of Pediatrics
Department of Pharmaceutical Sciences
DNA Methylation
journalArticle
July 2020 List
Kuerbitz JS
Kuerbitz SJ
Mella C
NEOMED College of Medicine
NEOMED College of Pharmacy
neuronatin
Oncotarget
osteosarcoma
Saeed H
Safadi F
Sinha S
Stanke J
Steele MA
tumor suppressor genes