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Bone mineral density in adolescent urinary stone formers: is sex important?

Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This…

The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine…

Tags: 2020, Chakraborty Ronith, Chauvin Abigail, Diabetic nephropathy, Endothelin, Endothelin antagonists, Focal segmental glomerulosclerosis, Hypertensive nephropathy, Kidney diseases (Basel, Kidney diseases (Basel, Switzerland), Krishnappa Vinod, Kusumi Kirsten, Nair Nikhil, NEOMED College of Graduate Studies Student, NEOMED College of Medicine Student, NEOMED Student Publications, Raina Rupesh, Shah Haikoo, Switzerland)

Overview of Monogenic or Mendelian Forms of Hypertension

Monogenic or Mendelian forms of hypertension are described as a group of conditions characterized by insults to the normal regulation of blood pressure by the kidney and adrenal gland. These alterations stem from single mutations that lead to…

Adolescents with urinary stones have elevated urine levels of inflammatory mediators

Urinary stones are increasing in children, primarily during adolescence. Although urinary stones are often viewed in the context of intermittent stone events, increasing evidence indicates that stones are a metabolic process associated with chronic…

Tags: 2019, Biomarker, Cytokine, Department of Pediatrics, Innate immunity, Interleukin, June 2019 Update, Ketz John, Kusumi Kirsten, NEOMED College of Medicine, Safadi Fayez, Saxena Vijay, Schwaderer Andrew, Spencer John David, urolithiasis

Comparison of Risk Factors for Pediatric Kidney Stone Formation: The Effects of Sex.

Background: Urinary stones are affecting more children, and pediatric stone formers have unique pathophysiology compared to adults. While adult stone formers are most frequently male, children have an age dependent sex prevalence. Under 10 years, a…

Tags: 2019, Age, Department of Internal Medicine, Frontiers in pediatrics, Khare Anshika, KIDNEY STONES, Kusumi Kirsten, Moe Sharon M, NEOMED College of Medicine, Pediatrics, Raina Rupesh, Safadi Fayez, Schwaderer Andrew L, sex, urolithiasis

Renal Calcium Oxalate Deposits Induce a Pro-Atherosclerotic and Pro-Osteoporotic Response in Mice.

Urinary stone disease (USD) is increasing in adult and pediatric populations. Adult and pediatric studies have demonstrated decreased bone mineral density and increased fracture rates. USD has also been independently linked to increased rates of…

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