1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.apsb.2015.01.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.apsb.2015.01.003</a>
Pages
113–122
Issue
2
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Circadian rhythms in liver metabolism and disease.
Publisher
An entity responsible for making the resource available
Acta pharmaceutica Sinica. B
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-03
Subject
The topic of the resource
ARC; arcuate nucleus; BMAL1; brain and muscle ARNT-like 1; CAR; cholesterol 7alpha-hydroxylase; circadian locomotor output cycles kaput; Circadian rhythm; CLOCK; constitutive androstane receptor; CRY; cryptochrome; CYP7A1; CYPs; cytochrome P450 enzymes; D-site binding protein; DBP; E-box; emergency medical technician; EMT; enhance box; FAA; familial advanced sleep-phase syndrome; farnesoid-X receptor; FASPS; FEO; food anticipatory activity; food entrainable oscillator; forkhead box O3; FOXO3; FXR; G protein-coupled bile acid receptor; glucose transporter 2; GLUT2; HDAC3; hepatic leukemia factor; HIP; histone deacetylase 3; HLF; hypoxia inducing protein; LDL; Liver; liver receptor homolog 1; low-density lipoprotein; LRH1; Metabolic syndrome; NAD+; nicotinamide adenine dinucleotide; PER; period; retinohypothalamic tract; retinoid-related orphan receptor alpha; RHT; ROR-response element; RORalpha; RORE; SCN; SHP; SIRT1; sirtuin 1; small heterodimer partner; suprachiasmatic nucleus; TEF; TGR5; thyrotroph embryonic factor; transcriptional translational feedback loop; TTFL; Type 2 diabetes
Creator
An entity primarily responsible for making the resource
Ferrell Jessica M; Chiang John Y L
Description
An account of the resource
Mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and dyslipidemia. Here, these associations are reviewed with respect to liver metabolism and disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.apsb.2015.01.003" target="_blank" rel="noreferrer noopener">10.1016/j.apsb.2015.01.003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Acta pharmaceutica Sinica. B
ARC
arcuate nucleus
BMAL1
brain and muscle ARNT-like 1
CAR
Chiang John Y L
cholesterol 7alpha-hydroxylase
circadian locomotor output cycles kaput
Circadian Rhythm
CLOCK
constitutive androstane receptor
CRY
cryptochrome
CYP7A1
CYPs
cytochrome P450 enzymes
D-site binding protein
DBP
Department of Integrative Medical Sciences
E-box
emergency medical technician
EMT
enhance box
FAA
familial advanced sleep-phase syndrome
farnesoid-X receptor
FASPS
FEO
Ferrell Jessica M
food anticipatory activity
food entrainable oscillator
forkhead box O3
FOXO3
FXR
G protein-coupled bile acid receptor
glucose transporter 2
GLUT2
HDAC3
hepatic leukemia factor
Hip
histone deacetylase 3
HLF
hypoxia inducing protein
LDL
Liver
liver receptor homolog 1
Low-density lipoprotein
LRH1
Metabolic syndrome
NAD+
NEOMED College of Medicine
nicotinamide adenine dinucleotide
PER
period
retinohypothalamic tract
retinoid-related orphan receptor alpha
RHT
ROR-response element
RORalpha
RORE
SCN
SHP
SIRT1
sirtuin 1
small heterodimer partner
suprachiasmatic nucleus
TEF
TGR5
thyrotroph embryonic factor
transcriptional translational feedback loop
TTFL
Type 2 diabetes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/ATVBAHA.118.311122" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/ATVBAHA.118.311122</a>
Pages
2448–2459
Issue
10
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice.
Publisher
An entity responsible for making the resource available
Arteriosclerosis, thrombosis, and vascular biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
human; LDL; LDLR protein; obeticholic acid; receptors; RNA stability; untranslated regions
Creator
An entity primarily responsible for making the resource
Singh Amar Bahadur; Dong Bin; Kraemer Fredric B; Xu Yanyong; Zhang Yanqiao; Liu Jingwen
Description
An account of the resource
Objective- The objective of this study was to determine whether and how activation of farnesoid X receptor (FXR) by obeticholic acid (OCA), a clinical FXR agonist, modulates liver low-density lipoprotein receptor (LDLR) expression under normolipidemic conditions. Approach and Results- Administration of OCA to chow-fed mice increased mRNA and protein levels of LDLR in the liver without affecting the sterol-regulatory element binding protein pathway. Profiling of known LDLR mRNA-binding proteins demonstrated that OCA treatment did not affect expressions of mRNA degradation factors hnRNPD (heterogeneous nuclear ribonucleoprotein D) or ZFP36L1 but increased the expression of Hu antigen R (HuR) an mRNA-stabilizing factor. Furthermore, inducing effects of OCA on LDLR and HuR expression were ablated in Fxr(-/-) mice. To confirm the post-transcriptional mechanism, we used transgenic mice (albumin-luciferase-untranslated region) that express a human LDLR mRNA 3' untranslated region luciferase reporter gene in the liver. OCA treatment led to significant rises in hepatic bioluminescence signals, Luc-untranslated region chimeric mRNA levels, and endogenous LDLR protein abundance, which were accompanied by elevations of hepatic HuR mRNA and protein levels in OCA-treated transgenic mice. In vitro studies conducted in human primary hepatocytes and HepG2 cells demonstrated that FXR activation by OCA and other agonists elicited the same inducing effect on LDLR expression as in the liver of normolipidemic mice. Furthermore, depletion of HuR in HepG2 cells by short interfering RNA transfection abolished the inducing effect of OCA on LDLR expression. Conclusions- Our study is the first to demonstrate that FXR activation increases LDLR expression in liver tissue by a post-transcriptional regulatory mechanism involving LDLR mRNA-stabilizing factor HuR.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/ATVBAHA.118.311122" target="_blank" rel="noreferrer noopener">10.1161/ATVBAHA.118.311122</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Arteriosclerosis, thrombosis, and vascular biology
Dong Bin
Human
Kraemer Fredric B
LDL
LDLR protein
Liu Jingwen
Obeticholic acid
Receptors
RNA Stability
Singh Amar Bahadur
untranslated regions
Xu Yanyong
Zhang Yanqiao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/lipd.12244" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/lipd.12244</a>
ISSN
1558-9307 0024-4201
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1002/lipd.12244" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/lipd.12244</a>
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Relationships between Very Low-Density Lipoproteins-Ceramides, -Diacylglycerols, and -Triacylglycerols in Insulin-Resistant Men.
Publisher
An entity responsible for making the resource available
Lipids
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-15
Subject
The topic of the resource
biomarkers; Ceramides; disease; humans; inflammation; kinetics; ldl; Lipids; Metabolic syndrome; NAFLD; NAFLD; obese men; secretion; sphingolipids; VLDL; VLDL
Creator
An entity primarily responsible for making the resource
Mucinski Justine M; Manrique-Acevedo Camila; Kasumov Takhar; Garrett Timothy J; Gaballah Ayman; Parks Elizabeth J
Description
An account of the resource
This short report describes the relationships between concentrations of ceramides (CER), diacylglycerols (DAG), triacylglycerols (TAG) in very low-density lipoproteins (VLDL) particles, and hepatic lipid accumulation. VLDL particles were isolated from male subjects (n = 12, mean +/- SD, age 42.1 +/- 5.4 years, BMI 37.4 +/- 4.1 kg/m(2) , ALT 45 +/- 21 U/L) and apolipoprotein B100 (apoB100),
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/lipd.12244" target="_blank" rel="noreferrer noopener">10.1002/lipd.12244</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Biomarkers
Ceramides
Department of Pharmaceutical Sciences
Disease
Gaballah Ayman
Garrett Timothy J
Humans
Inflammation
journalArticle
June 2020 Update II
Kasumov Takhar
Kinetics
LDL
Lipids
Manrique-Acevedo Camila
Metabolic syndrome
Mucinski Justine M
NAFLD
NEOMED College of Pharmacy
obese men
Parks Elizabeth J
secretion
sphingolipids
VLDL
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M039347</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2754-2762
Issue
10
Volume
54
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
apolipoprotein-b secretion; Biochemistry & Molecular Biology; cells; diabetes; extracellular signal-regulated kinase; fatty liver; function; induced insulin-resistance; ldl; lipid metabolism; liver; mitogen-activated protein kinase; Obesity; overproduction; oxidative stress; ubiquitination; vascular; vldl production
Creator
An entity primarily responsible for making the resource
Bi L P; Chiang J Y L; Ding W X; Dunn W; Roberts B; Li T G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">10.1194/jlr.M039347</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
apolipoprotein-b secretion
Bi L P
Biochemistry & Molecular Biology
Cells
Chiang J Y L
Diabetes
Ding W X
Dunn W
extracellular signal-regulated kinase
Fatty Liver
Function
induced insulin-resistance
Journal of lipid research
LDL
Li T G
Lipid Metabolism
Liver
mitogen-activated protein kinase
Obesity
overproduction
Oxidative Stress
Roberts B
ubiquitination
Vascular
vldl production
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M039347</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2754-2762
Issue
10
Volume
54
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
apolipoprotein-b secretion; Biochemistry & Molecular Biology; cells; diabetes; extracellular signal-regulated kinase; fatty liver; function; induced insulin-resistance; ldl; lipid metabolism; liver; mitogen-activated protein kinase; obesity; overproduction; oxidative stress; ubiquitination; vascular; vldl production
Creator
An entity primarily responsible for making the resource
Bi L P; Chiang J Y L; Ding W X; Dunn W; Roberts B; Li T G
Description
An account of the resource
Hepatic VLDL overproduction is a characteristic feature of diabetes and an important contributor to diabetic dyslipidemia. Hepatic sortilin 1 (Sort1), a cellular trafficking receptor, is a novel regulator of plasma lipid metabolism and reduces plasma cholesterol and triglycerides by inhibiting hepatic apolipoprotein B production. Elevated circulating free fatty acids play key roles in hepatic VLDL overproduction and the development of dyslipidemia. This study investigated the regulation of hepatic Sort1 in obesity and diabetes and the potential implications in diabetic dyslipidemia. Results showed that hepatic Sort1 protein was markedly decreased in mouse models of type I and type II diabetes and in human individuals with obesity and liver steatosis, whereas increasing hepatic Sort1 expression reduced plasma cholesterol and triglycerides in mice. Mechanistic studies showed that the saturated fatty acid palmitate activated extracellular signal-regulated kinase (ERK) and inhibited Sort1 protein by mechanisms involving Sort1 protein ubiquitination and degradation. Consistently, hepatic ERK signaling was activated in diabetic mice, whereas blocking ERK signaling by an ERK inhibitor increased hepatic Sort1 protein in mice. These results suggest that increased saturated fatty acids downregulate liver Sort1 protein, which may contribute to the development of dyslipidemia in obesity and diabetes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M039347" target="_blank" rel="noreferrer noopener">10.1194/jlr.M039347</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
apolipoprotein-b secretion
Bi L P
Biochemistry & Molecular Biology
Cells
Chiang J Y L
Diabetes
Ding W X
Dunn W
extracellular signal-regulated kinase
Fatty Liver
Function
induced insulin-resistance
Journal Article or Conference Abstract Publication
Journal of lipid research
LDL
Li T G
Lipid Metabolism
Liver
mitogen-activated protein kinase
Obesity
overproduction
Oxidative Stress
Roberts B
ubiquitination
Vascular
vldl production