1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1002/hep4.1341" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep4.1341</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
763-775
Issue
6
Volume
3
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Lipocalin‐2 Protects Against Diet‐Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes.
Publisher
An entity responsible for making the resource available
Hepatology Communications
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
FATTY liver; LIPOCALIN; LIVER disease treatment
Creator
An entity primarily responsible for making the resource
Xu Yanyong; Zhu Yingdong; Jadhav Kavita; Li Yuanyuan; Sun Huihui; Yin Liya; Kasumov Takhar; Chen Xiaoli; Zhang Yanqiao
Description
An account of the resource
Hepatocytes are the major source of hepatic lipocalin‐2 (LCN2), which is up‐regulated in response to inflammation, injury, or metabolic stress. So far, the role of hepatocyte‐derived LCN2 in the development of nonalcoholic fatty liver disease (NAFLD) remains unknown. Herein we show that overexpression of human LCN2 in hepatocytes protects against high fat/high cholesterol/high fructose (HFCF) diet–induced liver steatosis and nonalcoholic steatohepatitis by promoting lipolysis and fatty acid oxidation (FAO) and inhibiting de novo lipogenesis (DNL), lipid peroxidation, and apoptosis. LCN2 fails to reduce triglyceride accumulation in hepatocytes lacking sterol regulatory element‐binding protein 1. In contrast, Lcn2−/− mice have defective lipolysis, increased lipid peroxidation and apoptosis, and exacerbated NAFLD after being fed an HFCF diet. In primary hepatocytes, Lcn2 deficiency stimulates de novo lipogenesis but inhibits FAO. Conclusion: The current study indicates that hepatocyte LCN2 protects against diet‐induced NAFLD by regulating lipolysis, FAO, DNL, lipid peroxidation, and apoptosis. Targeting hepatocyte LCN2 may be useful for treatment of NAFLD. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.1002/hep4.1341" target="_blank" rel="noreferrer noopener">10.1002/hep4.1341</a>
2019
Chen Xiaoli
Department of Integrative Medical Sciences
Fatty Liver
Hepatology communications
Jadhav Kavita
Kasumov Takhar
Li Yuanyuan
LIPOCALIN
LIVER disease treatment
NEOMED College of Medicine
September 2019 Update
Sun Huihui
Xu Yanyong
Yin Liya
Zhang Yanqiao
Zhu Yingdong
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jmor.21099" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jmor.21099</a>
Pages
316-325
Issue
3
Volume
281
ISSN
0362-2525
Search for Full-text
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1002/jmor.21099" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1002/jmor.21099</a>
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Whale tear glands in the bowhead and the beluga whales: Source and function
Publisher
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Journal of Morphology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03
Subject
The topic of the resource
dolphin tursiops-truncatus; fluid; glands; harderian-gland; lacrimal gland; lactoferrin; lipocalin; localization; morphology; ocular glands; orbital whales; pacinian corpuscles; secretions
Creator
An entity primarily responsible for making the resource
Rehorek Susan J; Stimmelmayr Rapahela; George John C; Suydam Robert; McBurney Denise M; Thewissen J G M
Description
An account of the resource
Orbital glands are found in many tetrapod vertebrates, and are usually separate structures, consisting of individual glands lying in the eyelids and both canthi of the orbit. In cetaceans, however, the orbital glandular units are less distinct and have been described by numerous authors as a single, periorbital mass. There are few histochemical and immunhistochemical studies to date of these structures. In this study, we examined the orbital glandular region of both the bowhead whale (Balaena mysticetus: Mysticeti) and the beluga whale (Delphinapterus leucas: Odontoceti) using histological, histochemical, and immunohistochemical techniques. Histologically, in the bowhead, three glandular areas were noted (circumorbital, including Harderian and lacrimal poles), palpebral (midway in the lower eyelid), and rim (near the edge of the eyelid). In the beluga, there was only a large, continuous mass within the eyelid itself. Histochemical investigation suggests neither sexual dimorphism nor age-related differences, but both whales had two cell types freely intermingling with each other in all glandular masses. Large cells (cell type 1) were distended by four histochemically distinct intracellular secretory granules. Smaller cells (cell type 2) were not distended (fewer granules) and had two to three histochemically distinct intracellular secretory granules. The beluga orbital glands had additional lipid granules in cell type 1. Counterintuitively, both lipocalin and transferrin were localized to cell type 2 only. This intermingling of cell types is unusual for vertebrates in whom individual orbital glands usually have one cell type with one to two different secretory granules present. The heterogeneity of the orbital fluid produced by cetacean orbital glands implies a complex function, or series of functions, for these orbital glands and their role in producing the tear fluid.
Identifier
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<a href="http://doi.org/10.1002/jmor.21099" target="_blank" rel="noreferrer noopener">10.1002/jmor.21099</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Department of Anatomy & Neurobiology
dolphin tursiops-truncatus
fluid
George John C
glands
harderian-gland
Journal Article
Journal of morphology
journalArticle
June 2020 Update I
lacrimal gland
lactoferrin
LIPOCALIN
localization
McBurney Denise M
morphology
NEOMED College of Medicine
ocular glands
orbital whales
pacinian corpuscles
Rehorek Susan J
Secretions
Stimmelmayr Rapahela
Suydam Robert
Thewissen J G M