1
40
15
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90190-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90190-5</a>
Pages
50–52
Issue
1
Volume
122
Dublin Core
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Title
A name given to the resource
Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Membrane Potentials/drug effects; Hippocampus/drug effects/*physiology; Evoked Potentials/drug effects; Synaptic Transmission/*drug effects; Adenosine/*pharmacology; Synapses/*drug effects; Theophylline/analogs & derivatives/pharmacology
Creator
An entity primarily responsible for making the resource
Lambert N A; Teyler T J
Description
An account of the resource
The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late IPSPs evoked by direct activation of interneurons in the presence of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Directly activated IPSPs were unchanged by the selective adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT), but CPT reversed hyperpolarization and depression of late IPSPs produced by adenosine. These results indicate that adenosine depresses disynaptic IPSPs in area CA1 by decreasing synaptic activation of inhibitory neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90190-5" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90190-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Adenosine/*pharmacology
Animals
Evoked Potentials/drug effects
Hippocampus/drug effects/*physiology
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neuroscience letters
Quinoxalines/pharmacology
Rats
Synapses/*drug effects
Synaptic Transmission/*drug effects
Teyler T J
Theophylline/analogs & derivatives/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
90-94
Issue
1
Volume
255
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Analogs Of Cyclic-amp Decrease Gamma-aminobutyric Acid-a Receptor-mediated Chloride Current In Cultured Rat Hippocampal-neurons Via An Extracellular Site
Publisher
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Journal of Pharmacology and Experimental Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-10
Subject
The topic of the resource
Pharmacology & Pharmacy
Creator
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Lambert N A; Harrison N L
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Harrison N L
Journal Article or Conference Abstract Publication
Journal of Pharmacology and Experimental Therapeutics
Lambert N A
Pharmacology & Pharmacy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(91)90985-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(91)90985-5</a>
Pages
349–352
Issue
2
Volume
547
Dublin Core
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Title
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Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-05
Subject
The topic of the resource
Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Hippocampus/*drug effects; Evoked Potentials/drug effects; Baclofen/antagonists & inhibitors/*pharmacology; Barium/*pharmacology; Drug Resistance/physiology; Interneurons/drug effects; Neural Inhibition/drug effects; Receptors; GABA-A/*drug effects
Creator
An entity primarily responsible for making the resource
Lambert N A; Harrison N L; Teyler T J
Description
An account of the resource
The mechanism of disinhibition produced by (+/-)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Ba2+ prevented baclofen-induced hyperpolarization of pyramidal neurons but not depression of monosynaptic IPSPs by baclofen. Baclofen reversibly depressed monosynaptic IPSPs when applied close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that baclofen disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating receptors on the terminals of inhibitory neurons that are coupled to a Ba(2+)-insensitive effector mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(91)90985-5" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(91)90985-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Baclofen/antagonists & inhibitors/*pharmacology
Barium/*pharmacology
Brain research
Drug Resistance/physiology
Evoked Potentials/drug effects
GABA-A/*drug effects
Harrison N L
Hippocampus/*drug effects
In Vitro Techniques
Interneurons/drug effects
Lambert N A
Neural Inhibition/drug effects
Quinoxalines/pharmacology
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(89)90803-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(89)90803-3</a>
Pages
125–128
Issue
1
Volume
107
Dublin Core
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Title
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Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen.
Publisher
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Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-12
Subject
The topic of the resource
Animals; Rats; Action Potentials/drug effects; In Vitro Techniques; GABA-A Receptor Antagonists; Hippocampus/drug effects/*physiology; Baclofen/*analogs & derivatives/pharmacology; Neural Inhibition/*drug effects; Receptors; GABA-A/*physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Harrison N L; Kerr D I; Ong J; Prager R H; Teyler T J
Description
An account of the resource
The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potential from CA1 hippocampal neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(89)90803-3" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(89)90803-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Action Potentials/drug effects
Animals
Baclofen/*analogs & derivatives/pharmacology
GABA-A Receptor Antagonists
GABA-A/*physiology
Harrison N L
Hippocampus/drug effects/*physiology
In Vitro Techniques
Kerr D I
Lambert N A
Neural Inhibition/*drug effects
Neuroscience letters
Ong J
Prager R H
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90801-v</a>
Pages
129–131
Issue
1
Volume
203
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholinergic disinhibition in area CA1 of the rat hippocampus is not mediated by receptors located on inhibitory neurons.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Action Potentials/drug effects; Adenosine/pharmacology; Animals; Baclofen/pharmacology; Carbachol/pharmacology; Cholinergic/*drug effects; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; Hippocampus/*drug effects; In Vitro Techniques; Membrane Potentials/drug effects; Neurons/*drug effects; Parasympathetic Nervous System/*drug effects; Phorbol Esters/pharmacology; Quinoxalines/pharmacology; Rats; Receptors; Synaptic Transmission/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Teyler T J
Description
An account of the resource
We studied the effects of carbamylcholine (carbachol; CCh) on monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). CCh (30 microM) blocked late afterhyperpolarizations but did not depress GABAA receptor-mediated fast monosynaptic IPSPs or GABAB receptor-mediated late monosynaptic IPSPs. In the presence of CCh the GABAB receptor agonist (+/- )-baclofen (2 microM) reversibly hyperpolarized pyramidal neurons and depressed monosynaptic IPSPs as under control conditions. Phorbol-12,13-diacetate (PDAc; 10 microM) increased fast and depressed late monosynaptic IPSPs, and prevented depression of IPSPs by baclofen. These results suggest that cholinergic disinhibition in area CA1 of the hippocampus results from decreased synaptic excitation of inhibitory neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90801-v</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Adenosine/pharmacology
Animals
Baclofen/pharmacology
Carbachol/pharmacology
Cholinergic/*drug effects
European journal of pharmacology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
Hippocampus/*drug effects
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neurons/*drug effects
Parasympathetic Nervous System/*drug effects
Phorbol Esters/pharmacology
Quinoxalines/pharmacology
Rats
Receptors
Synaptic Transmission/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90831-d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90831-d</a>
Pages
101–104
Issue
1
Volume
124
Dublin Core
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Title
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Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
Animals; Rats; Action Potentials/drug effects; Quinoxalines/pharmacology; Bicuculline/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Ion Channel Gating/drug effects; Barium/pharmacology; Dendrites/chemistry; Enkephalins/metabolism/pharmacology; Hippocampus/*chemistry/ultrastructure; Naloxone/pharmacology; Nerve Endings/chemistry; Potassium Channels/drug effects; Receptors; Enkephalin; Opioid; Ala(2)-MePhe(4)-Gly(5)-; GABA-A/drug effects/physiology; mu; Opioid/*analysis
Creator
An entity primarily responsible for making the resource
Lambert N A; Harrison N L; Teyler T J
Description
An account of the resource
The mechanism of disinhibition produced by opioid peptides was studied using intracellular recording in area CA1 of rat hippocampal slices. The mu-selective opioid peptide [D-Ala2,N-Me-Phe4,Gly-ol5]-enkephalin (DAGO) reversibly depressed directly-activated, monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV) in a naloxone-sensitive manner. Depression of monosynaptic inhibitory postsynaptic potentials (IPSPs) by DAGO was not prevented by 1-2 mM Ba2+. DAGO reversibly depressed monosynaptic IPSPs when applied locally close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that DAGO disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating mu opiate receptors located on the terminals of inhibitory neurons, and by a Ba(2+)-insensitive mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90831-d" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90831-d</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Ala(2)-MePhe(4)-Gly(5)-
Animals
Barium/pharmacology
Bicuculline/pharmacology
Dendrites/chemistry
Enkephalin
Enkephalins/metabolism/pharmacology
GABA-A/drug effects/physiology
Harrison N L
Hippocampus/*chemistry/ultrastructure
Ion Channel Gating/drug effects
Lambert N A
mu
Naloxone/pharmacology
Nerve Endings/chemistry
Neuroscience letters
Opioid
Opioid/*analysis
Potassium Channels/drug effects
Quinoxalines/pharmacology
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1538-1548
Issue
5
Volume
66
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
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Title
A name given to the resource
Hyperpolarizing And Depolarizing Gaba-a Receptor-mediated Dendritic Inhibition In Area Ca1 Of The Rat Hippocampus
Publisher
An entity responsible for making the resource available
Journal of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
activity-dependent disinhibition; cortical-neurons; depression; electrophysiology; gamma-aminobutyric acid; lacunosum-moleculare interneurons; morphology; Neurosciences & Neurology; Physiology; pyramidal cells-invitro; responses; voltage-clamp
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. Gamma-aminobutyric acid(A) (GABA(A)) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABA(A) and late, GABA(B) receptor or-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABA(A) receptor antagonist bicuculline methiodide (BMI; 30-mu-M) and were not changed by the GABA(B) receptor antagonist P-[3-aminopropyl]-P-diethoxymethylphosphinic acid (CGP 35 348; 0.1-1.0 mM). CGP 35 348 (0.1 mM) reversibly blocked late monosynaptic IPSPs and late positive field potentials. These results suggest that fast field potentials are GABA(A) receptor-mediated population IPSPs (GABA(A), fast pIPSPs) and that late field potentials are GABA(B) receptor-mediated population IPSPs (GABA(B), late pIPSPs). 4. Fast pIPSPs were reversibly abolished when the extracellular Cl- concentration ([Cl-1]o) was reduced from 132 to 26 mM in parallel with a depolarizing shift in the reversal potential of fast IPSPs. Paired or repetitive stimulation in s. radiatum reversibly depressed fast pIPSPs and fast IPSPs. Paired-pulse depression of fast pIPSPs was reversibly antagonized by CGP 35 348 (0.40. 8 mM). 5. Laminar analysis of s. radiatum-evoked fast pIPSPs and one-dimensional CSD analysis revealed active current sources in s. radiatum and passive current sinks in s. oriens and s. lacunosum moleculare. S. radiatum sources were abolished by pressure application of BMI in s. radiatum but not in s. oriens. Stimulation in s. oriens, s. pyramidale, or s. lacunosum moleculare evoked GABA(A) current sources horizontal to the stimulation site. Changes in the dendritic location of inhibitory current with changes in stimulus location paralleled changes in the distribution of excitatory current. 6. In the presence of 4-aminopyridine (50-100-mu-M), DNQX and APV long-lasting depolarizing GABA(A) receptor-mediated responses (LLDs) occurred spontaneously or could be evoked. Current sinks associated with s. radiatum-evoked LLDs were located in the same dendritic area as sources associated with hyperpolarizing fast IPSPs. 7. These results suggest that activation of GABA(A) receptors located on pyramidal neuron apical and basal dendrites produces outward Cl-1 current and hyperpolarizing IPSPs. This suggests that depolarizing responses to dendritic GABA application and orthodromic activation in area CA1 do not result from inward chloride current.
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
activity-dependent disinhibition
Borroni A M
cortical-neurons
Depression
Electrophysiology
gamma-aminobutyric acid
Grover L M
Journal Article or Conference Abstract Publication
Journal of neurophysiology
lacunosum-moleculare interneurons
Lambert N A
morphology
Neurosciences & Neurology
Physiology
pyramidal cells-invitro
responses
Teyler T J
voltage-clamp
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1991.66.5.1538</a>
Pages
1538–1548
Issue
5
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Bicuculline/analogs & derivatives/pharmacology; Chlorides/pharmacology; Dendrites/drug effects/*physiology; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/*physiology; Hippocampus/*physiology; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials/drug effects; Models; Neurological; Neurons/drug effects/*physiology; Organophosphorus Compounds/pharmacology; Pyramidal Tracts/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABAA and late, GABAB receptor-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) and were not changed by the GABAB receptor antagonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">10.1152/jn.1991.66.5.1538</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Bicuculline/analogs & derivatives/pharmacology
Borroni A M
Chlorides/pharmacology
Dendrites/drug effects/*physiology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lambert N A
Mathematics
Membrane Potentials/drug effects
Models
Neurological
Neurons/drug effects/*physiology
Organophosphorus Compounds/pharmacology
Pyramidal Tracts/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(92)90439-e" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(92)90439-e</a>
Pages
215–218
Issue
2
Volume
135
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
*GABA-A Receptor Antagonists; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Baclofen/pharmacology; Hippocampus/cytology/*drug effects; In Vitro Techniques; Interneurons/drug effects/physiology; Membrane Potentials/drug effects; Quinoxalines/pharmacology; Rats; Synapses/drug effects; Zinc/*pharmacology
Creator
An entity primarily responsible for making the resource
Lambert N A; Levitin M; Harrison N L
Description
An account of the resource
The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potentials (IPSPs) were evoked in the presence of the excitatory amino acid (EAA) receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-amino-5-phosphonovalerate (APV). Addition of Zn2+ (0.3 mM) resulted in the appearance of long-lasting GDPs which obscured monosynaptic late IPSPs. The GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) blocked fast monosynaptic IPSPs and GDPs, revealing a monosynaptic late IPSP that was prolonged in the presence of Zn2+ and blocked by the GABAB receptor antagonist CGP 35,348 (100 microM). The selective GABAB receptor agonist baclofen (10 microM) depressed monosynaptic IPSPs and population excitatory postsynaptic potentials (pEPSPs) by acting at presynaptic GABAB receptors. Depression of synaptic potentials by baclofen was unaffected by Zn2+. These results suggest that induction of GDPs in area CA1 does not result from an action of Zn2+ at GABAB receptors. We suggest instead that Zn2+ induces GDPs by inducing synchronized discharge of GABAergic interneurons.
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<a href="http://doi.org/10.1016/0304-3940(92)90439-e" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(92)90439-e</a>
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*GABA-A Receptor Antagonists
1992
2-Amino-5-phosphonovalerate/pharmacology
Animals
Baclofen/pharmacology
Harrison N L
Hippocampus/cytology/*drug effects
In Vitro Techniques
Interneurons/drug effects/physiology
Lambert N A
Levitin M
Membrane Potentials/drug effects
Neuroscience letters
Quinoxalines/pharmacology
Rats
Synapses/drug effects
Zinc/*pharmacology
-
Text
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URL Address
<a href="http://doi.org/10.1016/0304-3940(89)90025-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(89)90025-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
137-142
Issue
1
Volume
105
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Title
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Modification Of Gabaa Receptor Function By An Analog Of Cyclic-amp
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Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-10
Subject
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Neurosciences & Neurology
Creator
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Harrison N L; Lambert N A
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<a href="http://doi.org/10.1016/0304-3940(89)90025-6" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(89)90025-6</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Harrison N L
Journal Article or Conference Abstract Publication
Lambert N A
Neuroscience letters
Neurosciences & Neurology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1993.69.5.1541</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1541-1555
Issue
5
Volume
69
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Title
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Role Of Hco3- Ions In Depolarizing Gaba-a Receptor-mediated Responses In Pyramidal Cells Of Rat Hippocampus
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Journal of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
central-nervous-system; cl-channels; cortical-neurons; cultured astrocytes; dendritic inhibition; gamma-aminobutyric acid; glial-cells; guinea-pig hippocampus; long-term potentiation; mammalian; Neurosciences & Neurology; Physiology; synaptic responses
Creator
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Grover L M; Lambert N A; Schwartzkroin P A; Teyler T J
Description
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1. Activation of GABA(A) receptors can produce both hyperpolarizing and depolarizing responses in CA1 pyramidal cells. The hyperpolarizing response is mediated by a Cl- conductance, but the ionic basis of the depolarizing response is not clear. We compared the GABA(A) receptor-mediated depolarizations induced by synaptically released gamma-aminobutyric acid [GABA; depolarizing inhibitory postsynaptic potentials (dIPSPs)] with those produced by exogenous GABA (depolarizing GABA responses). Short trains of high-frequency (200 Hz) stimuli were used to generate dIPSPs. We found that dIPSPs generated by trains of stimuli and depolarizing responses to exogenous GABA were accompanied by a conductance increase and had a similar reversal potential, indicating a similar ionic basis for both responses. 2. We wished to determine whether an HCO3- current contributed to the GABA(A)-mediated depolarizations. We found that dIPSPs and depolarizing GABA responses were sensitive to perfusion with HCO3--free medium. Interpretation of these data was complicated by the mixed nature of the responses: dIPSPs were invariably accompanied by conventional, Cl--mediated fast hyperpolarizing IPSPs (fIPSPs), and response to exogenous GABA usually consisted of biphasic hyperpolarizing and depolarizing responses. However, it was sometimes possible to elicit responses to GABA that appeared purely depolarizing (monophasic depolarizing GABA responses). 3. We analyzed monophasic depolarizing GABA responses and found no change in reversal potential when slices were perfused with HCO3--free medium. We also made whole-cell recordings from CA1 pyramidal cells, attempting to reduce [HCO3-]i, and compared the reversal potential for monophasic depolarizing GABA responses with similar responses recorded with fine intracellular microelectrodes. We found no difference in reversal potential. We also examined effects of the carbonic anhydrase inhibitor acetazolamide (ACTZ) on depolarizing GABA responses. ACTZ reduced these responses but did not change their reversal potential. 4. Effects of HCO3--free medium were not specific to GABA(A) receptor-mediated responses. GABA(B) receptor-mediated slow IPSPs (sIPSPs) were also reduced, as were excitatory postsynaptic potentials (EPSPs). Analyses of field potentials and spontaneous fIPSPs suggested a decrease in presynaptic excitability during perfusion with HCO3--free medium. In addition, pyramidal cells showed decreased input resistance when perfused with HCO 3--free medium. 5. The sensitivity of GABA(A) receptor-mediated depolarizations to HCO3--free medium can be explained by a decrease in presynaptic excitability and an increased resting conductance in postsynaptic neurons. Reduced presynaptic excitability and resting input resistance are also likely causes of the reduction in fast IPSPs, slow IPSPs, and EPSPs in HCO3--free medium. We suggest that these nonspecific effects of HCO3--free medium may be a consequence of an extracellular acidification. These data do not provide convincing evidence for involvement of an HCO3- conductance in the generation of dIPSPs and depolarizing GABA responses.
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<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">10.1152/jn.1993.69.5.1541</a>
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The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
central-nervous-system
cl-channels
cortical-neurons
cultured astrocytes
dendritic inhibition
gamma-aminobutyric acid
glial-cells
Grover L M
guinea-pig hippocampus
Journal Article or Conference Abstract Publication
Journal of neurophysiology
Lambert N A
Long-Term Potentiation
Mammalian
Neurosciences & Neurology
Physiology
Schwartzkroin P A
synaptic responses
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1993.69.5.1541</a>
Pages
1541–1555
Issue
5
Volume
69
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Role of HCO3- ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
Afferent Pathways/physiology; Animals; Bicarbonates/*metabolism; Culture Techniques; Electric Stimulation; GABA-A/*physiology; gamma-Aminobutyric Acid/physiology; Hippocampus/*physiology; Interneurons/physiology; Membrane Potentials/physiology; Neurons/physiology; Rats; Receptors; Synapses/physiology; Synaptic Transmission/*physiology
Creator
An entity primarily responsible for making the resource
Grover L M; Lambert N A; Schwartzkroin P A; Teyler T J
Description
An account of the resource
1. Activation of GABAA receptors can produce both hyperpolarizing and depolarizing responses in CA1 pyramidal cells. The hyperpolarizing response is mediated by a Cl- conductance, but the ionic basis of the depolarizing response is not clear. We compared the GABAA receptor-mediated depolarizations induced by synaptically released gamma-aminobutyric acid [GABA; depolarizing inhibitory postsynaptic potentials (dIPSPs)] with those produced by exogenous GABA (depolarizing GABA responses). Short trains of high-frequency (200 Hz) stimuli were used to generate dIPSPs. We found that dIPSPs generated by trains of stimuli and depolarizing responses to exogenous GABA were accompanied by a conductance increase and had a similar reversal potential, indicating a similar ionic basis for both responses. 2. We wished to determine whether an HCO3- current contributed to the GABAA-mediated depolarizations. We found that dIPSPs and depolarizing GABA responses were sensitive to perfusion with HCO3(-)-free medium. Interpretation of these data was complicated by the mixed nature of the responses: dIPSPs were invariably accompanied by conventional, Cl(-)-mediated fast hyperpolarizing IPSPs (fIPSPs), and response to exogenous GABA usually consisted of biphasic hyperpolarizing and depolarizing responses. However, it was sometimes possible to elicit responses to GABA that appeared purely depolarizing (monophasic depolarizing GABA responses). 3. We analyzed monophasic depolarizing GABA responses and found no change in reversal potential when slices were perfused with HCO(3-)-free medium. We also made whole-cell recordings from CA1 pyramidal cells, attempting to reduce [HCO3-]i, and compared the reversal potential for monophasic depolarizing GABA responses with similar responses recorded with fine intracellular microelectrodes. We found no difference in reversal potential. We also examined effects of the carbonic anhydrase inhibitor acetazolamide (ACTZ) on depolarizing GABA responses. ACTZ reduced these responses but did not change their reversal potential. 4. Effects of HCO(3-)-free medium were not specific to GABAA receptor-mediated responses. GABAB receptor-mediated slow IPSPs (sIPSPs) were also reduced, as were excitatory postsynaptic potentials (EPSPs). Analyses of field potentials and spontaneous fIPSPs suggested a decrease in presynaptic excitability during perfusion with HCO(3-)-free medium. In addition, pyramidal cells showed decreased input resistance when perfused with HCO(3-)-free medium. 5. The sensitivity of GABAA receptor-mediated depolarizations to HCO(3-)-free medium can be explained by a decrease in presynaptic excitability and an increased resting conductance in postsynaptic neurons.(ABSTRACT TRUNCATED AT 400 WORDS)
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<a href="http://doi.org/10.1152/jn.1993.69.5.1541" target="_blank" rel="noreferrer noopener">10.1152/jn.1993.69.5.1541</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent Pathways/physiology
Animals
Bicarbonates/*metabolism
Culture Techniques
Electric Stimulation
GABA-A/*physiology
gamma-Aminobutyric Acid/physiology
Grover L M
Hippocampus/*physiology
Interneurons/physiology
Journal of neurophysiology
Lambert N A
Membrane Potentials/physiology
Neurons/physiology
Rats
Receptors
Schwartzkroin P A
Synapses/physiology
Synaptic Transmission/*physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(90)90851-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(90)90851-y</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
272-276
Issue
2
Volume
119
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Title
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The Actions Of 2-hydroxy-saclofen At Presynaptic Gaba-b Receptors In The Rat Hippocampus
Publisher
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Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-11
Subject
The topic of the resource
Neurosciences & Neurology
Creator
An entity primarily responsible for making the resource
Harrison N L; Lovinger D M; Lambert N A; Teyler T J; Prager R; Ong J; Kerr D I B
Identifier
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<a href="http://doi.org/10.1016/0304-3940(90)90851-y" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(90)90851-y</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Harrison N L
Journal Article or Conference Abstract Publication
Kerr D I B
Lambert N A
Lovinger D M
Neuroscience letters
Neurosciences & Neurology
Ong J
Prager R
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(92)90390-p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(92)90390-p</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
337-341
Issue
3
Volume
211
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Title
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The Actions Of 3-aminopropanephosphinic Acid At Gaba(b) Receptors In Rat Hippocampus
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European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
2-hydroxy-saclofen; b receptors; baclofen; brain slices; ca3 pyramidal cells; excitatory transmission; gaba(b) receptors (postsynaptic); gaba(b) receptors (presynaptic); inhibitory transmission; in-vitro; neurons; patch; Pharmacology & Pharmacy; potent; slice recording; synapses; transmission
Creator
An entity primarily responsible for making the resource
Lovinger D M; Harrison N L; Lambert N A
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<a href="http://doi.org/10.1016/0014-2999(92)90390-p" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(92)90390-p</a>
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The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1992
2-hydroxy-saclofen
b receptors
baclofen
brain slices
ca3 pyramidal cells
European journal of pharmacology
excitatory transmission
gaba(b) receptors (postsynaptic)
gaba(b) receptors (presynaptic)
Harrison N L
in-vitro
inhibitory transmission
Lambert N A
Lovinger D M
Neurons
patch
Pharmacology & Pharmacy
potent
slice recording
synapses
Transmission
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
P17-P17
Volume
412
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Title
A name given to the resource
The Effects Of Protein-kinase Activators On Gabaa Receptor Function In Cultured Rat Hippocampal-neurons
Publisher
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Journal of Physiology-London
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-05
Subject
The topic of the resource
Neurosciences & Neurology; Physiology
Creator
An entity primarily responsible for making the resource
Harrison N L; Lambert N A
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Harrison N L
Journal Article or Conference Abstract Publication
Journal of Physiology-London
Lambert N A
Neurosciences & Neurology
Physiology