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40
5
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Text
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URL Address
<a href="http://doi.org/10.1152/jn.00409.2020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00409.2020</a>
ISSN
1522-1598
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1152/jn.00409.2020" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1152/jn.00409.2020</a>
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Update Year & Number
September 2020 List
NEOMED College
NEOMED College of Medicine
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Department of Anatomy & Neurobiology
NEOMED Postdoc Publications
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Title
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Muscle activity and kinematics show different responses to recurrent laryngeal nerve lesion in mammal swallowing.
Publisher
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Journal Of Neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-23
Subject
The topic of the resource
Swallowing; aspiration; variation; neuromuscular function
Creator
An entity primarily responsible for making the resource
Gould FDH;Lammers Andrew R;Mayerl CJ;Ohlemacher J;German RZ
Description
An account of the resource
Understanding the interactions between neural and musculoskeletal systems is key to identifying mechanisms of functional failure. Mammalian swallowing is a complex, poorly understood motor process. Lesion of the recurrent laryngeal nerve, a sensory and motor nerve of the upper airway, results in airway protection failure (liquid entry into the airway) during swallowing through an unknown mechanism. We examined how muscle and kinematic changes after recurrent laryngeal nerve lesion relate to airway protection in eight infant pigs. We tested two hypotheses: 1) Kinematics and muscle function will both change in response to lesion in swallows with and without airway protection failure 2) Differences in both kinematics and muscle function will predict whether airway protection failure occurs in lesion and intact pigs. We recorded swallowing with high speed videofluoroscopy and simultaneous electromyography of oropharyngeal muscles pre- and post-recurrent laryngeal nerve lesion. Lesion changed the relationship between airway protection and timing of tongue and hyoid movements. Changes in onset and duration of hyolaryngeal muscles post-lesion were less associated with airway protection outcomes. The tongue and hyoid kinematics all predicted airway protection outcomes differently pre and post-lesion. Onset and duration of activity of activity in only one infrahyoid and one suprahyoid muscle showed a change in predictive relationship pre- and post-lesion. Kinematics of the tongue and hyoid more directly reflect changes in airway protection s pre and post lesion than muscle activation patterns. Identifying mechanisms of airway protection failure requires specific functional hypotheses that link neural motor outputs to muscle activation to specific movements.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00409.2020" target="_blank" rel="noreferrer noopener">10.1152/jn.00409.2020</a>
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journalArticle
2020
Aspiration
Department of Anatomy & Neurobiology
German RZ
Gould FDH
Journal of neurophysiology
journalArticle
Lammers Andrew R
Mayerl CJ
NEOMED College of Medicine
NEOMED Postdoc Publications
neuromuscular function
Ohlemacher J
September 2020 List
swallowing
Variation
-
Text
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URL Address
<a href="http://doi.org/10.1007/s00455-020-10100-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-020-10100-7</a>
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s00455-020-10100-7" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s00455-020-10100-7</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of Superior Laryngeal Nerve Lesion on Kinematics of Swallowing and Airway Protection in an Infant Pig Model.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03
Subject
The topic of the resource
Deglutition; Deglutition disorders; Kinematics; Biomechanics; Animal model; Airway; Superior laryngeal nerve; Neural control; Swallow
Creator
An entity primarily responsible for making the resource
Lammers Andrew R; Abid Saja; Ding Peng; German Rebecca Z
Description
An account of the resource
The superior laryngeal nerve provides detailed sensory information from the mucosal surfaces of laryngeal structures superior to the vocal folds, including the valleculae. Injury to this nerve results in airway penetration and aspiration. Furthermore, such injuries might have an impact on the function of multiple structures involved in intraoral transport and swallowing due to connections within the brainstem. We sought to determine the effects of a surgical lesion of the superior laryngeal nerve on kinematics of the tongue, hyoid, and epiglottis during swallowing. We implanted radio-opaque markers into five infant pigs under anesthesia. Then we fed milk mixed with contrast agent to the pigs while they were recorded via video fluoroscopy, before and after a surgery to transect the superior laryngeal nerve. We digitized and rated airway protection in 177 swallows. We found that in most animals, swallow duration was shorter after nerve lesion. The hyoid also traveled a shorter distance after lesion. Frequently, individuals reacted differently to the same nerve lesion. We suggest that these differences are due to individual differences in neurological connections. When comparing hyoid kinematics between swallows with successful or failed airway protection, we found more consistency among individuals. This indicates that protecting the airway requires specific sets of kinematic events to occur, regardless of the neurological differences among individuals.
Identifier
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<a href="http://doi.org/10.1007/s00455-020-10100-7" target="_blank" rel="noreferrer noopener">10.1007/s00455-020-10100-7</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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Journal Article
2020
Abid Saja
Airway
Animal model
biomechanics
Deglutition
Deglutition disorders
Department of Anatomy & Neurobiology
Ding Peng
Dysphagia
German Rebecca Z
Kinematics
Lammers Andrew R
NEOMED College of Medicine
Neural control
Superior laryngeal nerve
Swallow
-
Text
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URL Address
<a href="http://doi.org/10.3389/fneur.2019.01301" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fneur.2019.01301</a>
Pages
1301-1301
Volume
10
Search for Full-text
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fneur.2019.01301" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fneur.2019.01301</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology; NEOMED Postdoc Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Specific Vagus Nerve Lesion Have Distinctive Physiologic Mechanisms of Dysphagia.
Publisher
An entity responsible for making the resource available
Frontiers in neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
1905-07
Subject
The topic of the resource
Dysphagia; Animal model; Kinematics; Superior laryngeal nerve; recurrent laryngeal nerve
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Lammers Andrew R; Mayerl Christopher J; German Rebecca Z
Description
An account of the resource
Swallowing is complex at anatomical, functional, and neurological levels. The connections among these levels are poorly understood, yet they underpin mechanisms of swallowing pathology. The complexity of swallowing physiology means that multiple failure points may exist that lead to the same clinical diagnosis (e.g., aspiration). The superior laryngeal nerve (SLN) and the recurrent laryngeal nerve (RLN) are branches of the vagus that innervate different structures involved in swallowing. Although they have distinct sensory fields, lesion of either nerve is associated clinically with increased aspiration. We tested the hypothesis that despite increased aspiration in both case, oropharyngeal kinematic changes and their relationship to aspiration would be different in RLN and SLN lesioned infant pigs. We compared movements of the tongue and epiglottis in swallows before and after either RLN or SLN lesion. We rated swallows for airway protection. Posterior tongue ratio of safe swallows changed in RLN (p = 0.01) but not SLN lesioned animals. Unsafe swallows post lesion had different posterior tongue ratios in RLN and SLN lesioned animals. Duration of epiglottal inversion shortened after lesion in SLN animals (p = 0.02) but remained unchanged in RLN animals. Thus, although SLN and RLN lesion lead to the same clinical outcome (increased aspiration), the mechanisms of failure of airway protection are different, which suggests that effective therapies may be different with each injury. Understanding the specific pathophysiology of swallowing associated with specific neural insults will help develop targeted, disease appropriate treatments.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fneur.2019.01301" target="_blank" rel="noreferrer noopener">10.3389/fneur.2019.01301</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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Journal Article
2019
Animal model
Department of Anatomy & Neurobiology
Dysphagia
Frontiers in neurology
German Rebecca Z
Gould François D H
Kinematics
Lammers Andrew R
Mayerl Christopher J
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
Recurrent laryngeal nerve
Superior laryngeal nerve
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/japplphysiol.00946.2015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/japplphysiol.00946.2015</a>
Pages
495–502
Issue
5
Volume
120
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Central nervous system integration of sensorimotor signals in oral and pharyngeal structures: oropharyngeal kinematics response to recurrent laryngeal nerve lesion.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-03
Subject
The topic of the resource
Animals; Central Nervous System/*physiology; dysphagia; Feeding Methods; Female; infant; Larynx/*physiology; Male; mammalian feeding; Newborn; Oropharynx/*physiology; Pharynx/*physiology; Recurrent Laryngeal Nerve/*physiology; Sensation/physiology; Sensorimotor Cortex/*physiology; swallow control; Swine; tongue kinematics; Tongue/physiology
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Ohlemacher Jocelyn; Lammers Andrew R; Gross Andrew; Ballester Ashley; Fraley Luke; German Rebecca Z
Description
An account of the resource
Safe, efficient liquid feeding in infant mammals requires the central coordination of oropharyngeal structures innervated by multiple cranial and spinal nerves. The importance of laryngeal sensation and central sensorimotor integration in this system is poorly understood. Recurrent laryngeal nerve lesion (RLN) results in increased aspiration, though the mechanism for this is unclear. This study aimed to determine the effect of unilateral RLN lesion on the motor coordination of infant liquid feeding. We hypothesized that 1) RLN lesion results in modified swallow kinematics, 2) postlesion oropharyngeal kinematics of unsafe swallows differ from those of safe swallows, and 3) nonswallowing phases of the feeding cycle show changed kinematics postlesion. We implanted radio opaque markers in infant pigs and filmed them pre- and postlesion with high-speed videofluoroscopy. Markers locations were digitized, and swallows were assessed for airway protection. RLN lesion resulted in modified kinematics of the tongue relative to the epiglottis in safe swallows. In lesioned animals, safe swallow kinematics differed from unsafe swallows. Unsafe swallow postlesion kinematics resembled prelesion safe swallows. The movement of the tongue was reduced in oral transport postlesion. Between different regions of the tongue, response to lesion was similar, and relative timing within the tongue was unchanged. RLN lesion has a pervasive effect on infant feeding kinematics, related to the efficiency of airway protection. The timing of tongue and hyolaryngeal kinematics in swallows is a crucial locus for swallow disruption. Laryngeal sensation is essential for the central coordination in feeding of oropharyngeal structures receiving motor inputs from different cranial nerves.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/japplphysiol.00946.2015" target="_blank" rel="noreferrer noopener">10.1152/japplphysiol.00946.2015</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Animals
Ballester Ashley
Central Nervous System/*physiology
Department of Anatomy & Neurobiology
Dysphagia
Feeding Methods
Female
Fraley Luke
German Rebecca Z
Gould François D H
Gross Andrew
Infant
Journal of applied physiology (Bethesda, Md. : 1985)
Lammers Andrew R
Larynx/*physiology
Male
mammalian feeding
NEOMED College of Medicine
Newborn
Ohlemacher Jocelyn
Oropharynx/*physiology
Pharynx/*physiology
Recurrent Laryngeal Nerve/*physiology
Sensation/physiology
Sensorimotor Cortex/*physiology
swallow control
Swine
tongue kinematics
Tongue/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-015-9648-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-015-9648-8</a>
Pages
714–722
Issue
6
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
Animal; Animals; Aspiration; Biological; Deglutition; Deglutition – Physiology; Deglutition disorders; Deglutition Disorders – Etiology; Deglutition Disorders – Physiopathology; Deglutition Disorders/*etiology/physiopathology; Deglutition/*physiology; Disease Models; Esophagus; Esophagus – Physiopathology; Esophagus/*physiopathology; Human; Infant; Laryngeal Nerves – Injuries; Laryngeal Nerves – Physiopathology; Models; Oropharynx – Physiopathology; Oropharynx/*physiopathology; Recurrent laryngeal nerve; Recurrent Laryngeal Nerve Injuries/*complications/physiopathology; Recurrent Laryngeal Nerve/*physiopathology; Swine
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Lammers Andrew R; Ohlemacher Jocelyn; Ballester Ashley; Fraley Luke; Gross Andrew; German Rebecca Z
Description
An account of the resource
Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN unilaterally in an infant mammalian animal model to characterize the degree and variability of dysphagia in a controlled experimental setting. We tested the hypotheses that (1) both airway protection and esophageal function would be compromised by lesion, (2) given our design, variability between multiple post-lesion trials would be minimal, and (3) variability among individuals would be minimal. Individuals' swallowing performance was assessed pre- and post-lesion using high speed VFSS. Aspiration was assessed using the Infant Mammalian Penetration-Aspiration Scale (IMPAS). Esophageal function was assessed using two measures devised for this study. Our results indicate that RLN lesion leads to increased frequency of aspiration, and increased esophageal dysfunction, with significant variation in these basic patterns at all levels. On average, aspiration worsened with time post-lesion. Within a single feeding sequence, the distribution of unsafe swallows varied. Individuals changed post-lesion either by increasing average IMPAS score, or by increasing variation in IMPAS score. Unilateral RLN transection resulted in dysphagia with both compromised airway protection and esophageal function. Despite consistent, experimentally controlled injury, significant variation in response to lesion remained. Aspiration following RLN lesion was due to more than unilateral vocal fold paralysis. We suggest that neurological variation underlies this pattern.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-015-9648-8" target="_blank" rel="noreferrer noopener">10.1007/s00455-015-9648-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Animal
Animals
Aspiration
Ballester Ashley
Biological
Deglutition
Deglutition – Physiology
Deglutition disorders
Deglutition Disorders – Etiology
Deglutition Disorders – Physiopathology
Deglutition Disorders/*etiology/physiopathology
Deglutition/*physiology
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
Esophagus
Esophagus – Physiopathology
Esophagus/*physiopathology
Fraley Luke
German Rebecca Z
Gould François D H
Gross Andrew
Human
Infant
Lammers Andrew R
Laryngeal Nerves – Injuries
Laryngeal Nerves – Physiopathology
Models
NEOMED College of Medicine
Ohlemacher Jocelyn
Oropharynx – Physiopathology
Oropharynx/*physiopathology
Recurrent laryngeal nerve
Recurrent Laryngeal Nerve Injuries/*complications/physiopathology
Recurrent Laryngeal Nerve/*physiopathology
Swine