Browse Items · NEOMED Bibliography Database

Analysis of connective tissues by laser capture microdissection and reverse transcriptase-polymerase chain reaction.

Studies of gene expression from bone, cartilage, and other tissues are complicated by the fact that their RNA, collected and pooled for analysis, often represents a wide variety of composite cells distinct in individual phenotype, age, and state of…

Analysis of osteopontin in mouse growth plate cartilage by application of laser capture microdissection and RT-PCR.

Gene expression of osteopontin (OPN) has been investigated in mice by application of laser capture microdissection (LCM) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. LCM permits individual cells to be isolated ("captured")…

Development of bone and cartilage in tissue-engineered human middle phalanx models.

Human middle phalanges were tissue-engineered with midshaft scaffolds of poly(L-lactide-epsilon-caprolactone) [P(LA-CL)], hydroxyapatite-P(LA-CL), or beta-tricalcium phosphate-P(LA-CL) and end plate scaffolds of bovine chondrocyte-seeded polyglycolic…

Tags: *Models, 2009, Aggrecans/genetics/metabolism, Animals, Biological, Bone Development/drug effects/*physiology, Calcium Phosphates/pharmacology, Cartilage/cytology/drug effects/*growth & development, Cattle, Chondrocytes/cytology/drug effects/metabolism, Collagen Type II/genetics/metabolism, Durapatite/pharmacology, Electron, Enjo Mitsuhiro, Experimental, Finger Phalanges/cytology/diagnostic imaging/drug effects/*physiology, Gene Expression Profiling, Gene Expression Regulation/drug effects, Humans, Implants, Integrin-Binding Sialoprotein, Isogai Noritaka, Jacquet Robin, Landis William J, Lowder Elizabeth, Mice, Microscopy, Paraffin Embedding, Periosteum/cytology/drug effects, Polyesters/pharmacology, Radiography, Scanning, Sialoglycoproteins/genetics/metabolism, Tissue engineering. Part A, Tissue Engineering/*methods, Tissue Scaffolds/chemistry, Wada Yoshitaka

Effects of FGF-2 and OP-1 in vitro on donor source cartilage for auricular reconstruction tissue engineering.

OBJECTIVE: Microtia is a congenital partial or total loss of the external ear with current treatment approaches involving autologous construction from costal cartilage. Alternatively, tissue engineering provides possible use of normal or microtia…

Histochemical analyses of tissue-engineered human menisci.

The field of tissue engineering remains one of the least explored areas of current meniscal research but holds great promise. In this investigation, meniscal fibrochondrocytes were isolated from fresh human meniscal tissue and seeded onto synthetic…

Mineral deposition in the extracellular matrices of vertebrate tissues: identification of possible apatite nucleation sites on type I collagen.

The possible means by which type I collagen may mediate mineralization in normal vertebrate bone, tendon, dentin and cementum as well as in pathological mineral formation are not fully understood. One consideration in this regard is that the…

Tags: *Calcification, 2009, Animals, Apatites/*metabolism, Calcium/metabolism, Cells, tissues, organs, Collagen Type I/chemistry/*metabolism, Extracellular Matrix/*metabolism, Humans, Landis William J, Microfibrils/chemistry, Models, Molecular, Phosphates/metabolism, Physiologic, Silver Frederick H, Vertebrates/*metabolism

Murine metapodophalangeal sesamoid bones: morphology and potential means of mineralization underlying function.

Normal murine metapodophalangeal sesamoid bones, closely associated with tendons, were examined in terms of their structure and mineralization with reference to their potential function following crystal deposition. This study utilized radiography,…

The nature and role of periosteum in bone and cartilage regeneration.

This study was undertaken to determine whether periosteum from different bone sources in a donor results in the same formation of bone and cartilage. In this case, periosteum obtained from the cranium and mandible (examples of tissue supporting…

The potential of tissue engineering in orthopedics.

This article presents models of human phalanges and small joints developed by tissue engineering. Biodegradable polymer scaffolds support growth of osteoblasts, chondrocytes, and tenocytes after implantation of the models in athymic mice. The…

The structure and function of normally mineralizing avian tendons.

The leg tendons of certain avian species normally calcify. The gastrocnemius, or Achilles, tendon of the domestic turkey, Meleagris gallopavo, is one such example. Its structure and biomechanical properties have been studied to model the adaptive…

Tags: 2002, Animals, Biomechanical Phenomena, Birds/*anatomy & histology/*physiology, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Landis William J, Minerals/*metabolism, Non-programmatic, Silver Frederick H, Tendons/anatomy & histology/*cytology/*physiology

Tissue engineering models of human digits: effect of periosteum on growth plate cartilage development.

Tissue-engineered middle phalanx constructs of human digits were investigated to determine whether periosteum wrapped partly about model midshafts mediated cartilage growth plate formation. Models were fabricated by suturing ends of polymer midshafts…

Tissue-engineered meniscal constructs.

The medial and lateral menisci play important roles in knee biomechanics, kinematics, and stability. Unfortunately, these structures are prone to damage and, because of a tenuous blood supply, have great difficulty healing. Many interventions have…

Tags: *Biocompatible Materials, *Tissue Engineering, 2007, American journal of orthopedics (Belle Mead, N.J.), Biomechanical Phenomena, Humans, Kay David B, Landis William J, Menisci, Schoenfeld Andrew J, Tibial/*anatomy & histology/physiology

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