1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-018-9881-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-018-9881-z</a>
Pages
627–635
Issue
5
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
*Animal model; *Deglutition; *Development; *Infant; *Recurrent laryngeal nerve; *Respiration; *Sensorimotor; Animal; Animal Population Groups; Animals; Biological; Deglutition – Physiology; Deglutition Disorders; Deglutition/*physiology; Disease Models; Humans; Laryngeal Nerves – Injuries; Laryngeal Nerves – Physiology; Larynx – Physiology; Larynx/*physiology; Models; Newborn; Questionnaires; Recurrent Laryngeal Nerve Injuries/*complications; Recurrent Laryngeal Nerve/physiology; Respiration; Swine
Creator
An entity primarily responsible for making the resource
Ballester Ashley; Gould Francois; Bond Laura; Stricklen Bethany; Ohlemacher Jocelyn; Gross Andrew; DeLozier Katherine R; Buddington Randall; Buddington Karyl; Danos Nicole; German Rebecca
Description
An account of the resource
The timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and supplies the intrinsic muscles of the larynx, experience a significant incidence of dysphagia. Using our validated infant pig model, we determined the interaction between this nerve damage and the coordination between respiration and swallowing during postnatal development. We recorded 23 infant pigs at two ages (neonatal and older, pre-weaning) feeding on milk with barium using simultaneous high-speed videofluoroscopy and measurements of thoracic movement. With a complete linear model, we tested for changes with maturation, and whether these changes are the same in control and lesioned individuals. We found (1) the timing of swallowing and respiration coordination changes with maturation; (2) no overall effect of RLN lesion on the timing of coordination, but (3) a greater magnitude of maturational change occurs with RLN injury. We also determined that animals with no surgical intervention did not differ from animals that had surgery for marker placement and a sham procedure for nerve lesion. The coordination between respiration and swallowing changes in normal, intact individuals to provide increased airway protection prior to weaning. Further, in animals with an RLN lesion, the maturation process has a larger effect. Finally, these results suggest a high level of brainstem sensorimotor interactions with respect to these two functions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-018-9881-z" target="_blank" rel="noreferrer noopener">10.1007/s00455-018-9881-z</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Animal model
*Deglutition
*Development
*Infant
*Recurrent laryngeal nerve
*Respiration
*Sensorimotor
2018
Animal
Animal Population Groups
Animals
Ballester Ashley
Biological
Bond Laura
Buddington Karyl
Buddington Randall
Danos Nicole
Deglutition – Physiology
Deglutition disorders
Deglutition/*physiology
DeLozier Katherine R
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
German Rebecca
Gould Francois
Gross Andrew
Humans
Laryngeal Nerves – Injuries
Laryngeal Nerves – Physiology
Larynx – Physiology
Larynx/*physiology
Models
NEOMED College of Medicine
Newborn
Ohlemacher Jocelyn
Questionnaires
Recurrent Laryngeal Nerve Injuries/*complications
Recurrent Laryngeal Nerve/physiology
Respiration
Stricklen Bethany
Swine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-017-9832-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-017-9832-0</a>
Pages
51–62
Issue
1
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-02
Subject
The topic of the resource
*Animal model; *Aspiration; *Deglutition; *Deglutition disorders; *Dysphagia; *Infant; *Laryngeal vestibule closure; *Recurrent laryngeal nerve; Animal; Animal Population Groups; Animals; Aspiration – Etiology; Aspiration/*etiology; Biological; Deglutition – Physiology; Deglutition Disorders – Etiology; Deglutition Disorders/*etiology; Deglutition/*physiology; Disease Models; Humans; Laryngeal Nerve Injuries/*complications; Laryngeal Nerves – Injuries; Larynx; Models; Newborn; Oropharynx; Pneumonia; Questionnaires; Swine
Creator
An entity primarily responsible for making the resource
Gross Andrew; Ohlemacher Jocelyn; German Rebecca; Gould Francois
Description
An account of the resource
Recurrent laryngeal nerve (RLN) injury in neonates, a complication of head and neck surgeries, leads to increased aspiration risk and swallowing dysfunction. The severity of resulting sequelae range from morbidity, such as aspiration pneumonia, to mortality from infection and failure to thrive. The timing of airway protective events including laryngeal vestibule closure (LVC) is implicated in aspiration. We unilaterally transected the RLN in an infant pig model to observe changes in the timing of swallowing kinematics with lesion and aspiration. We recorded swallows using high-speed video-fluoroscopic swallow studies (VFSS) and scored them using the Infant Mammalian Penetration and Aspiration Scale (IMPAS). We hypothesized that changes would occur in swallowing kinematics (1) between RLN lesion and control animals, and (2) among safe swallows (IMPAS 1), penetration swallows (IMPAS 3), and aspiration swallows (IMPAS 7). We observed numerous changes in timing following RLN lesion in safe and unsafe swallows, suggesting pervasive changes in the coordination of oropharyngeal function. The timing of LVC, posterior tongue, and hyoid movements differed between pre- and post-lesion in safe swallows. Posterior tongue kinematics differed for post-lesion swallows with penetration. The timing and duration of LVC and posterior tongue movement differed between aspiration swallows pre- and post-lesion. After lesion, safe swallows and swallows with aspiration differed in timing of LVC, laryngeal vestibule opening, and posterior tongue and hyoid movements. The timing of thyrohyoid muscle activity varied with IMPAS, but not lesion. Further study into the pathophysiology of RLN lesion-induced swallowing dysfunction is important to developing novel therapies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-017-9832-0" target="_blank" rel="noreferrer noopener">10.1007/s00455-017-9832-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Animal model
*Aspiration
*Deglutition
*Deglutition disorders
*Dysphagia
*Infant
*Laryngeal vestibule closure
*Recurrent laryngeal nerve
2018
Animal
Animal Population Groups
Animals
Aspiration – Etiology
Aspiration/*etiology
Biological
Deglutition – Physiology
Deglutition Disorders – Etiology
Deglutition Disorders/*etiology
Deglutition/*physiology
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
German Rebecca
Gould Francois
Gross Andrew
Humans
Laryngeal Nerve Injuries/*complications
Laryngeal Nerves – Injuries
Larynx
Models
NEOMED College of Medicine
Newborn
Ohlemacher Jocelyn
Oropharynx
Pneumonia
Questionnaires
Swine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-016-9762-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-016-9762-2</a>
Pages
362–373
Issue
3
Volume
32
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pre-pharyngeal Swallow Effects of Recurrent Laryngeal Nerve Lesion on Bolus Shape and Airway Protection in an Infant Pig Model.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
*Aspiration; *Deglutition; *Deglutition disorders; *Infant; *Oro-pharyngeal pathophysiology; *Recurrent laryngeal nerve; Animal Studies; Animals; Aspiration – Etiology; Aspiration/etiology; Deglutition – Physiology; Deglutition Disorders – Etiology; Deglutition Disorders – Physiopathology; Deglutition Disorders/*etiology/physiopathology; Deglutition/physiology; Laryngeal Nerve Injuries/*complications; Laryngeal Nerves – Injuries; Newborn; Pneumonia; Swine
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Yglesias B; Ohlemacher J; German R Z
Description
An account of the resource
Recurrent laryngeal nerve (RLN) damage in infants leads to increased dysphagia and aspiration pneumonia. Recent work has shown that intraoral transport and swallow kinematics change following RLN lesion, suggesting potential changes in bolus formation prior to the swallow. In this study, we used geometric morphometrics to understand the effect of bolus shape on penetration and aspiration in infants with and without RLN lesion. We hypothesized (1) that geometric bolus properties are related to airway protection outcomes and (2) that in infants with RLN lesion, the relationship between geometric bolus properties and dysphagia is changed. In five infant pigs, dysphagia in 188 swallows was assessed using the Infant Mammalian Penetration-Aspiration Scale (IMPAS). Using images from high-speed VFSS, bolus shape, bolus area, and tongue outline were quantified digitally. Bolus shape was analyzed using elliptical Fourier analysis, and tongue outline using polynomial curve fitting. Despite large inter-individual differences, significant within individual effects of bolus shape and bolus area on airway protection exist. The relationship between penetration-aspiration score and both bolus area and shape changed post lesion. Tongue shape differed between pre- and post-lesion swallows, and between swallows with different IMPAS scores. Bolus shape and area affect airway protection outcomes. RLN lesion changes that relationship, indicating that proper bolus formation and control by the tongue require intact laryngeal sensation. The impact of RLN lesion on dysphagia is pervasive.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-016-9762-2" target="_blank" rel="noreferrer noopener">10.1007/s00455-016-9762-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aspiration
*Deglutition
*Deglutition disorders
*Infant
*Oro-pharyngeal pathophysiology
*Recurrent laryngeal nerve
2017
Animal Studies
Animals
Aspiration – Etiology
Aspiration/etiology
Deglutition – Physiology
Deglutition Disorders – Etiology
Deglutition Disorders – Physiopathology
Deglutition Disorders/*etiology/physiopathology
Deglutition/physiology
Department of Anatomy & Neurobiology
Dysphagia
German R Z
Gould François D H
Laryngeal Nerve Injuries/*complications
Laryngeal Nerves – Injuries
NEOMED College of Medicine
Newborn
Ohlemacher J
Pneumonia
Swine
Yglesias B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00455-015-9648-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-015-9648-8</a>
Pages
714–722
Issue
6
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.
Publisher
An entity responsible for making the resource available
Dysphagia
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
Animal; Animals; Aspiration; Biological; Deglutition; Deglutition – Physiology; Deglutition disorders; Deglutition Disorders – Etiology; Deglutition Disorders – Physiopathology; Deglutition Disorders/*etiology/physiopathology; Deglutition/*physiology; Disease Models; Esophagus; Esophagus – Physiopathology; Esophagus/*physiopathology; Human; Infant; Laryngeal Nerves – Injuries; Laryngeal Nerves – Physiopathology; Models; Oropharynx – Physiopathology; Oropharynx/*physiopathology; Recurrent laryngeal nerve; Recurrent Laryngeal Nerve Injuries/*complications/physiopathology; Recurrent Laryngeal Nerve/*physiopathology; Swine
Creator
An entity primarily responsible for making the resource
Gould Francois D H; Lammers Andrew R; Ohlemacher Jocelyn; Ballester Ashley; Fraley Luke; Gross Andrew; German Rebecca Z
Description
An account of the resource
Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN unilaterally in an infant mammalian animal model to characterize the degree and variability of dysphagia in a controlled experimental setting. We tested the hypotheses that (1) both airway protection and esophageal function would be compromised by lesion, (2) given our design, variability between multiple post-lesion trials would be minimal, and (3) variability among individuals would be minimal. Individuals' swallowing performance was assessed pre- and post-lesion using high speed VFSS. Aspiration was assessed using the Infant Mammalian Penetration-Aspiration Scale (IMPAS). Esophageal function was assessed using two measures devised for this study. Our results indicate that RLN lesion leads to increased frequency of aspiration, and increased esophageal dysfunction, with significant variation in these basic patterns at all levels. On average, aspiration worsened with time post-lesion. Within a single feeding sequence, the distribution of unsafe swallows varied. Individuals changed post-lesion either by increasing average IMPAS score, or by increasing variation in IMPAS score. Unilateral RLN transection resulted in dysphagia with both compromised airway protection and esophageal function. Despite consistent, experimentally controlled injury, significant variation in response to lesion remained. Aspiration following RLN lesion was due to more than unilateral vocal fold paralysis. We suggest that neurological variation underlies this pattern.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00455-015-9648-8" target="_blank" rel="noreferrer noopener">10.1007/s00455-015-9648-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Animal
Animals
Aspiration
Ballester Ashley
Biological
Deglutition
Deglutition – Physiology
Deglutition disorders
Deglutition Disorders – Etiology
Deglutition Disorders – Physiopathology
Deglutition Disorders/*etiology/physiopathology
Deglutition/*physiology
Department of Anatomy & Neurobiology
Disease Models
Dysphagia
Esophagus
Esophagus – Physiopathology
Esophagus/*physiopathology
Fraley Luke
German Rebecca Z
Gould François D H
Gross Andrew
Human
Infant
Lammers Andrew R
Laryngeal Nerves – Injuries
Laryngeal Nerves – Physiopathology
Models
NEOMED College of Medicine
Ohlemacher Jocelyn
Oropharynx – Physiopathology
Oropharynx/*physiopathology
Recurrent laryngeal nerve
Recurrent Laryngeal Nerve Injuries/*complications/physiopathology
Recurrent Laryngeal Nerve/*physiopathology
Swine