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URL Address
<a href="http://doi.org/10.1371/journal.pgen.1007048" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pgen.1007048</a>
Pages
e1007048–e1007048
Issue
10
Volume
13
Dublin Core
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Title
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Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.
Publisher
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PLoS genetics
Date
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2017
2017-10
Subject
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Female; Male; Animals; Mice; Neurogenesis; Neurons/cytology; Neuropilin-1/genetics/*metabolism; Semaphorin-3A/genetics/*metabolism; Signal Transduction; Spiral Ganglion/cytology/*embryology; Inbred C57BL; Knockout
Creator
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Salehi Pezhman; Ge Marshall X; Gundimeda Usha; Michelle Baum Leah; Lael Cantu Homero; Lavinsky Joel; Tao Litao; Myint Anthony; Cruz Charlene; Wang Juemei; Nikolakopoulou Angeliki Maria; Abdala Carolina; Kelley Matthew William; Ohyama Takahiro; Coate Thomas Matthew; Friedman Rick A
Description
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Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL) in mice. In this study, we generated and characterized an inner ear-specific Nrp1 conditional knockout (CKO) mouse line because Nrp1 constitutive knockouts are embryonic lethal. In situ hybridization demonstrated weak Nrp1 mRNA expression late in embryonic cochlear development, but increased expression in early postnatal stages when cochlear hair cell innervation patterns have been shown to mature. At postnatal day 5, Nrp1 CKO mice showed disorganized outer spiral bundles and enlarged microvessels of the stria vascularis (SV) but normal spiral ganglion cell (SGN) density and presynaptic ribbon body counts; however, we observed enlarged SV microvessels, reduced SGN density, and a reduction of presynaptic ribbons in the outer hair cell region of 4-month-old Nrp1 CKO mice. In addition, we demonstrated elevated hearing thresholds of the
Identifier
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<a href="http://doi.org/10.1371/journal.pgen.1007048" target="_blank" rel="noreferrer noopener">10.1371/journal.pgen.1007048</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Abdala Carolina
Animals
Coate Thomas Matthew
Cruz Charlene
Female
Friedman Rick A
Ge Marshall X
Gundimeda Usha
Inbred C57BL
Kelley Matthew William
Knockout
Lael Cantu Homero
Lavinsky Joel
Male
Mice
Michelle Baum Leah
Myint Anthony
Neurogenesis
Neurons/cytology
Neuropilin-1/genetics/*metabolism
Nikolakopoulou Angeliki Maria
Ohyama Takahiro
PLoS genetics
Salehi Pezhman
Semaphorin-3A/genetics/*metabolism
Signal Transduction
Spiral Ganglion/cytology/*embryology
Tao Litao
Wang Juemei