1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.radonc.2015.10.018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.radonc.2015.10.018</a>
Pages
547–551
Issue
3
Volume
118
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Predictive model for survival in patients having repeat radiation treatment for painful bone metastases.
Publisher
An entity responsible for making the resource available
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-03
Subject
The topic of the resource
*Models; Aged; Bone metastases; Bone Neoplasms/*mortality/*radiotherapy/secondary; Dose Fractionation; Female; Humans; Male; Middle Aged; Predictive model; Predictive Value of Tests; Proportional Hazards Models; Radiation; Randomized Controlled Trials as Topic/methods; Re-irradiation; Statistical; Survival; Survival Analysis; Survival Rate
Creator
An entity primarily responsible for making the resource
Chow Edward; Ding Keyue; Parulekar Wendy R; Wong Rebecca K S; van der Linden Yvette M; Roos Daniel; Hartsell William F; Hoskin Peter; Wu Jackson S Y; Nabid Abdenour; Leer Jan Willem; Vonk Ernest; Babington Scott; Demas William F; Wilson Carolyn F; Brundage Michael; Zhu Liting; Meyer Ralph M
Description
An account of the resource
PURPOSE: To establish a survival prediction model in the setting of a randomized trial of re-irradiation for painful bone metastases. METHODS: Data were randomly divided into training and testing sets with an approximately 3:2 ratio. Baseline factors of gender, primary cancer site, KPS, worst-pain score and age were included with backward variable selection to derive a model using the training set. A partial score was assigned by dividing the value of each statistically significant regression coefficient by the smallest statistically significant regression coefficient. The survival prediction score (SPS) was obtained by adding together partial scores for the variables that were statistically significant. Three risk groups were modelled. RESULTS: The training set included 460 patients and the testing set 351 patients. Only KPS and primary cancer site reached the 5%-significance level. Summing up the partial scores assigned to KPS (90-100, 0; 70-80, 1; 50-60, 2) and primary cancer site (breast, 0; prostate, 1.3; other, 2.6; lung, 3) totalled the SPS. The 1/3 and 2/3 percentiles of the SPS were 2 and 3.6. For the testing set, the median survival of the 3 groups was not reached, 11.3 (95% C.I. 8.5 - not reached) and 5.2 months (95% C.I. 3.7-6.5). The 3, 6 and 12 month survival rates for the worst group were 64.4% (95% C.I. 55.3-72.1%), 43.0% (95% C.I. 34.0-51.8%) and 19.7% (95% C.I. 12.4-28.1%) respectively, similar to that in the training set. CONCLUSION: This survival prediction model will assist in choosing dose fractionation. We recommend a single 8 Gy in the worst group identified.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.radonc.2015.10.018" target="_blank" rel="noreferrer noopener">10.1016/j.radonc.2015.10.018</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Models
2016
Aged
Babington Scott
Bone metastases
Bone Neoplasms/*mortality/*radiotherapy/secondary
Brundage Michael
Chow Edward
Demas William F
Ding Keyue
Dose Fractionation
Female
Hartsell William F
Hoskin Peter
Humans
Leer Jan Willem
Male
Meyer Ralph M
Middle Aged
Nabid Abdenour
Parulekar Wendy R
Predictive model
Predictive Value of Tests
Proportional Hazards Models
Radiation
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Randomized Controlled Trials as Topic/methods
Re-irradiation
Roos Daniel
Statistical
Survival
Survival Analysis
Survival Rate
van der Linden Yvette M
Vonk Ernest
Wilson Carolyn F
Wong Rebecca K S
Wu Jackson S Y
Zhu Liting