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Text
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URL Address
<a href="http://doi.org/10.1152/ajpheart.1994.266.2.H531" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1994.266.2.H531</a>
Pages
H531–539
Issue
2
Volume
266
Dublin Core
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Title
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Myocardial work load is a major determinant of norepinephrine-induced left ventricular dysfunction.
Publisher
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The American journal of physiology
Date
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1994
1994-02
Subject
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Anesthesia; Animals; Blood Pressure/*drug effects; Cardiovascular; Consciousness; Diastole/drug effects; Dose-Response Relationship; Drug; General; Heart Rate/*drug effects; Heart/drug effects/*physiology; Left/drug effects/*physiology; Models; Norepinephrine/*pharmacology; Pentobarbital; Rabbits; Systole/drug effects; Time Factors; Ventricular Function
Creator
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Bosso F J; Allman F D; Pilati C F
Description
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This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was produced in both conscious and pentobarbital sodium-anesthetized rabbits with the same dose of NE (10 micrograms priming bolus plus 2.5 micrograms.kg-1 x min-1 for 2.5 h). After NE treatment, LV function was evaluated in vitro and found to be markedly diminished in the rabbits that had an elevated P-R product. In contrast, LV function was not significantly affected when the P-R product was maintained near control levels during NE treatment. In separate experiments, rabbit hearts were isolated and exposed to NE (10,000 or 50,000 pg/ml) for 2.5 h under low P-R product conditions. These hearts exhibited a dose-dependent decrease in LV function that was modest compared with that observed in rabbits that had elevated P-R products during in vivo NE treatment. Our results suggest that high concentrations of NE may cause modest degrees of LV dysfunction independently of increases in myocardial energy demand, but the LV dysfunction is exacerbated when myocardial energy demand is elevated.
Identifier
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<a href="http://doi.org/10.1152/ajpheart.1994.266.2.H531" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1994.266.2.H531</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Allman F D
Anesthesia
Animals
Blood Pressure/*drug effects
Bosso F J
Cardiovascular
Consciousness
Diastole/drug effects
Dose-Response Relationship
Drug
General
Heart Rate/*drug effects
Heart/drug effects/*physiology
Left/drug effects/*physiology
Models
Norepinephrine/*pharmacology
Pentobarbital
Pilati C F
Rabbits
Systole/drug effects
The American journal of physiology
Time Factors
Ventricular Function