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Text
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URL Address
<a href="http://doi.org/10.1002/ana.10731" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ana.10731</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
547-551
Issue
4
Volume
54
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Dublin Core
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Title
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Neuropathological findings in West Nile virus encephalitis: A case report
Publisher
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Annals of Neurology
Date
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2003
2003-10
Subject
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fever; infection; myelitis; Neurosciences & Neurology; New York; outbreak; Pathology
Creator
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Agamanolis D P; Leslie M J; Caveny E A; Guarner J; Shieh W J; Zaki S R
Description
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A 67-year-old woman had fever, myalgias, progressive weakness, and respiratory insufficiency. In 9 days, flaccid areflexic quadriparesis and bulbar palsy developed. She died 26 days after the onset of her illness. Serum and cerebrospinal fluid serology were positive for West Nile virus. Neuropathological study showed changes consistent with a viral encephalomyelitis, similar to poliomyelitis. The brainstem showed neuronal loss and multiple foci of necrosis. The spinal cord showed severe loss of anterior and posterior horn neurons. Immunohistochemistry identified West Nile virus antigens in the brainstem and spinal cord. Paralysis, in West Nile virus encephalitis, is caused by destruction of motor neurons.
Identifier
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<a href="http://doi.org/10.1002/ana.10731" target="_blank" rel="noreferrer noopener">10.1002/ana.10731</a>
Format
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Journal Article or Conference Abstract Publication
2003
Agamanolis D P
Annals of Neurology
Caveny E A
fever
Guarner J
Infection
Journal Article or Conference Abstract Publication
Leslie M J
myelitis
Neurosciences & Neurology
New York
outbreak
Pathology
Shieh W J
Zaki S R