1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hep.28712" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep.28712</a>
Pages
1072–1085
Issue
4
Volume
64
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.
Publisher
An entity responsible for making the resource available
Hepatology (Baltimore, Md.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-10
Subject
The topic of the resource
*Intestinal Absorption; Animals; Bile Acids and Salts/*chemistry; Biological Transport; Cholesterol/*metabolism; Cytoplasmic and Nuclear/*physiology; Inbred C57BL; Mice; Receptors
Creator
An entity primarily responsible for making the resource
Xu Yang; Li Fei; Zalzala Munaf; Xu Jiesi; Gonzalez Frank J; Adorini Luciano; Lee Yoon-Kwang; Yin Liya; Zhang Yanqiao
Description
An account of the resource
UNLABELLED: Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that the FXR agonist, obeticholic acid (OCA), increases fecal cholesterol excretion and macrophage reverse cholesterol transport (RCT) dependent on activation of hepatic FXR. OCA does not increase biliary cholesterol secretion, but inhibits intestinal cholesterol absorption. OCA markedly inhibits hepatic cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool size and altered bile acid composition, with the alpha/beta-muricholic acid proportion in bile increased by 2.6-fold and taurocholic acid (TCA) level reduced by 71%. Overexpression of Cyp8b1 or concurrent overexpression of Cyp7a1 and Cyp8b1 normalizes TCA level, bile acid composition, and intestinal cholesterol absorption. CONCLUSION: Activation of FXR inhibits intestinal cholesterol absorption by modulation of bile acid pool size and composition, thus leading to increased RCT. Targeting hepatic FXR and/or bile acids may be useful for boosting RCT and preventing the development of atherosclerosis. (Hepatology 2016;64:1072-1085).
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/hep.28712" target="_blank" rel="noreferrer noopener">10.1002/hep.28712</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Intestinal Absorption
2016
Adorini Luciano
Animals
Bile Acids and Salts/*chemistry
Biological Transport
Cholesterol/*metabolism
Cytoplasmic and Nuclear/*physiology
Department of Integrative Medical Sciences
Gonzalez Frank J
Hepatology (Baltimore, Md.)
Inbred C57BL
Lee Yoon-Kwang
Li Fei
Mice
NEOMED College of Medicine
Receptors
Xu Jiesi
Xu Yang
Yin Liya
Zalzala Munaf
Zhang Yanqiao