1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpgi.00170.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpgi.00170.2004</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
G60-G66
Issue
1
Volume
288
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Fxr-activating Ligands Inhibit Rabbit Asbt Expression Via Fxr-shp-ftf Cascade
Publisher
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American Journal of Physiology-Gastrointestinal and Liver Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
bile-acid transporter; cloning; down-regulation; Gastroenterology & Hepatology; identification; ileal; messenger-rna; negative feedback-regulation; nuclear receptor; Physiology; rats; real-time
Creator
An entity primarily responsible for making the resource
Li H; Chen F; Shang Q; Pan L X; Shneider B L; Chiang J Y L; Forman B M; Ananthanarayanan M; Tint G S; Salen G; Xu G R
Description
An account of the resource
The regulation of the rabbit apical sodium-dependent bile acid transporter ( ASBT) was studied both in vivo and in vitro. New Zealand White rabbits were fed 0.5% deoxycholic acid (DCA) or SC-435, a competitive ASBT inhibitor, for 1 wk. In DCA-fed rabbits, ASBT expression was repressed, associated with activated FXR, and evidenced by increased ileal short heterodimer partner (SHP) mRNA. Feeding SC-435 to the rabbits blocked bile acid absorption, decreased SHP mRNA, and increased ASBT expression. A 1.9-kb rabbit ASBT 5'-flanking region (promoter) was cloned, and a cis-acting element for alpha-fetoprotein transcription factor (FTF) was identified (-1166/-1158). The effects of transcriptional factors and different bile acids on the rabbit ASBT promoter were studied in Caco-2 cells. FTF stimulated the rabbit ASBT promoter activity fourfold but not after the FTF binding site was deleted from the promoter. Increasing the SHP protein notably inhibited FTF-dependent trans-activation of rabbit ASBT. Adding hydrophobic bile acids deoxycholic acid, chenodeoxycholic acid, and cholic acid, activating ligands for FXR, inhibited rabbit ASBT promoter activity in Caco-2 cells, but this inhibitory effect was abolished after the FTF binding site was deleted. Ursodeoxycholic acid and ursocholic acid, nonactivating ligands for FXR, did not repress ASBT promoter activity. Thus the rabbit ASBT promoter is negative-feedback regulated by bile acids via a functional FTF binding site. Only FXR-activating ligands can downregulate rabbit ASBT expression through the regulatory cascade FXR-SHP-FTF.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpgi.00170.2004" target="_blank" rel="noreferrer noopener">10.1152/ajpgi.00170.2004</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2005
American Journal of Physiology-Gastrointestinal and Liver Physiology
Ananthanarayanan M
bile-acid transporter
Chen F
Chiang J Y L
Cloning
Down-Regulation
Forman B M
Gastroenterology & Hepatology
identification
ileal
Journal Article or Conference Abstract Publication
Li H
messenger-rna
negative feedback-regulation
Nuclear Receptor
Pan L X
Physiology
Rats
real-time
Salen G
Shang Q
Shneider B L
Tint G S
Xu G R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S102-S102
Volume
64
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Influenza immunization influences TNF-like weak inducer of apoptosis (TWEAK) levels in older adults
Publisher
An entity responsible for making the resource available
Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-05
Subject
The topic of the resource
Geriatrics & Gerontology
Creator
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Ahmed S; Ouyang M; Li H; Walston J; Leng S
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2016
Ahmed S
Geriatrics & Gerontology
Journal Article or Conference Abstract Publication
Journal of the American Geriatrics Society
Leng S
Li H
Ouyang M
Walston J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0121826" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0121826</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-13
Issue
3
Volume
10
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Title
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Identification of Multiple Metabolic Enzymes from Mice Cochleae Tissue Using a Novel Functional Proteomics Technology
Publisher
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PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-03
Subject
The topic of the resource
Animal tissues; Beef; Biology; cancer; cancer metabolism; cell metabolism; Cochlea; draft; Drug therapy; E coli; Electrophoresis; Elution; Enzymatic activity; Enzyme assays; Enzyme metabolism; Enzymes; Feasibility studies; Functional analysis; Gel electrophoresis; Genes; Genomics; Hearing impairment; Kinases; Mass spectrometry; Mass spectroscopy; medicine; messenger-rna; metabolism; mice; NAD(P)H oxidase; NADH; Neurobiology; Neurosciences; Nicotinamide adenine dinucleotide; Noise; Otolaryngology; Oxidation-reduction reactions; Phosphatase; Protein expression; proteins; Proteomes; Proteomics; Science & Technology - Other Topics; Sciences: Comprehensive Works; Scientific imaging; Studies; Substance abuse treatment; Technology; United States--US
Creator
An entity primarily responsible for making the resource
Wang D L; Li H; Liang R Q; Bao J X
Description
An account of the resource
A new type of technology in proteomics was developed in order to separate a complex protein mixture and analyze protein functions systematically. The technology combines the ability of two-dimensional gel electrophoresis (2-DE) to separate proteins with a protein elution plate (PEP) to recover active proteins for functional analysis and mass spectrometry (MS)-based identification. In order to demonstrate the feasibility of this functional proteomics approach, NADH and NADPH-dependent oxidases, major redox enzyme families, were identified from mice cochlear tissue after a specific drug treatment. By comparing the enzymatic activity between mice that were treated with a drug and a control group significant changes were observed. Using MS, five NADH-dependent oxidases were identified that showed highly altered enzymatic activities due to the drug treatment. In essence, the PEP technology allows for a systematic analysis of a large enzyme family from a complex proteome, providing insights in understanding the mechanism of drug treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0121826" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0121826</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2015
Animal tissues
Bao J X
Beef
Biology
Cancer
cancer metabolism
cell metabolism
Cochlea
draft
Drug Therapy
E coli
Electrophoresis
Elution
Enzymatic activity
Enzyme assays
Enzyme metabolism
Enzymes
Feasibility Studies
Functional analysis
Gel electrophoresis
Genes
Genomics
Hearing impairment
Journal Article
Kinases
Li H
Liang R Q
Mass spectrometry
Mass spectroscopy
Medicine
messenger-rna
Metabolism
Mice
NAD(P)H oxidase
NADH
Neurobiology
Neurosciences
nicotinamide adenine dinucleotide
Noise
otolaryngology
Oxidation-reduction reactions
Phosphatase
PloS one
PROTEIN expression
Proteins
Proteomes
proteomics
Science & Technology - Other Topics
Sciences: Comprehensive Works
Scientific imaging
Studies
Substance abuse treatment
Technology
United States--US
Wang D L