Rapid Development Of Edema And Its Relationship To Degree Of Pulmonary-hypertension In Neurogenic Pulmonary-edema (npe)
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Maron M B; Holcomb P H; Dawson C A; Rickaby D A; Clough A V; Linehan J H
Faseb Journal
1993
1993-02
Journal Article or Conference Abstract Publication
n/a
MODEL-FREE NUMERICAL DECONVOLUTION OF RECIRCULATING INDICATOR CONCENTRATION CURVES
Physiology; Sport Sciences; parameters; camera; computation; extravascular lung water; indicator dilution; pulmonary circulation; transport functions; vascular transit time
This paper investigates two model-free methods for numerical deconvolution of recirculating indicator concentration curves. The two methods, damped least squares and discrete orthogonal polynomial deconvolution, are applied to simulated data to verify the reliability of the algorithms. Both deconvolution methods provide damping that results in estimated transport functions that are smooth and reasonable estimates of the actual simulated transport function. On convolution with the simulated input curve, the estimated transport functions provide good fits to the simulated output curve. In addition, methods for identifying an optimal solution and for truncating the artifactually long oscillatory tails of the estimated transport functions are proposed, which appear to allow for reasonably accurate estimation of the mean transit times and variances of the transport functions as well. When either method was applied to indicator dilution data obtained from the pulmonary artery and left atrium, it was computationally stable while producing transport functions that when convolved with the input concentration curves provided good fits to the output concentration curves. The combined simulation and experimental results suggest that the proposed methods should be useful for estimating circulation transport functions from indicator dilution data.
Clough A V; Cui D Y; Linehan J H; Krenz G S; Dawson C A; Maron M B
Journal of Applied Physiology
1993
1993-03
Journal Article or Conference Abstract Publication
n/a
Edema development and recovery in neurogenic pulmonary edema.
Animals; Atrial Function; Blood Gas Analysis; Blood Volume; Dogs; Extravascular Lung Water/drug effects/*physiology; Female; Hemodynamics; Left; Male; Pulmonary Artery/physiopathology; Pulmonary Circulation/drug effects/physiology; Pulmonary Edema/chemically induced/*physiopathology; Radio-Iodinated; Serum Albumin; Sympathetic Nervous System/physiopathology
We determined the time course of changes in extravascular lung water (EVLW) that occur after massive sympathetic activation produced by intracisternal veratrine administration in chloralose-anesthetized dogs. Three groups of dogs were studied. In the first group (n = 9), acute increases in EVLW (occurring within minutes) were determined both by measuring extravascular thermal volume and by gravimetric analysis. In the second (n = 6) and third (n = 7) groups, changes in EVLW were followed for 2-3 h after veratrine administration. Extravascular thermal volume was measured in the second group. In the third group, right atrial injections of a vascular indicator (125I-labeled serum albumin) and an extravascular indicator (3HOH) were made while blood was sampled from the pulmonary artery (PA) and left atrium, and EVLW was determined by deconvolution of the left atrial and PA concentration-time curves. Indicator-dilution and gravimetric EVLW increased acutely only in dogs in which PA pressure exceeded 60 Torr, with two- to four-fold increases in EVLW being observed in dogs that developed the highest PA pressures (maximum 94 Torr). Thus, severe edema can develop rapidly after massive sympathetic nervous system activation but requires extreme degrees of pulmonary hypertension. In several dogs after the acute increase in EVLW associated with the pulmonary hypertension, the indicator-dilution EVLW decreased with time. These decreases appear to effect clearance of edema fluid rather than alterations in perfusion.
Maron M B; Holcomb P H; Dawson C A; Rickaby D A; Clough A V; Linehan J H
Journal of applied physiology (Bethesda, Md. : 1985)
1994
1994-09
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<a href="http://doi.org/10.1152/jappl.1994.77.3.1155" target="_blank" rel="noreferrer noopener">10.1152/jappl.1994.77.3.1155</a>