1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
35–52
Issue
1
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.
Publisher
An entity responsible for making the resource available
Journal of submicroscopic cytology and pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
Female; Animals; Body Weight; Lipids/blood; Organ Size; Cricetinae; Mesocricetus; Epithelium/drug effects/ultrastructure; Estradiol/*toxicity; Medroxyprogesterone/*toxicity; Gallbladder/*drug effects/metabolism/ultrastructure; Microscopy; Electron; Scanning
Creator
An entity primarily responsible for making the resource
Karkare S; Kelly T R; Gilloteaux J
Description
An account of the resource
Light (LM), transmission (TEM), and scanning (SEM) electron microscopy were used to characterize morphological changes induced in the gallbladder epithelium of female Syrian hamsters in response to one-month estradiol alone (E) and estradiol with medroxyprogesterone (E + MP) treatments. TEM data were correlated with the SEM observations. Compared with control (C), E- and E + MP-treated hamsters showed significant decreases in body weight, while the liver and gallbladder, and uterus weights increased. Moreover, E treatment induced some subcellular changes (microvilli, nucleus, mitochondria, RER, glycogen, abundant apical granules). The E + MP treatment appeared to exacerbate these similar changes and, in addition, induced apical excrescences and cell shedding. Both E and E + MP gallbladders showed luminal micelles, cellular debris and crystalliths associated with mucus. Simultaneously, an increased acidification of the mucoid content of the apical granules was noticed.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Body Weight
Cricetinae
Electron
Epithelium/drug effects/ultrastructure
Estradiol/*toxicity
Female
Gallbladder/*drug effects/metabolism/ultrastructure
Gilloteaux J
Journal of submicroscopic cytology and pathology
Karkare S
Kelly T R
Lipids/blood
Medroxyprogesterone/*toxicity
Mesocricetus
Microscopy
Organ Size
Scanning
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
53–74
Issue
1
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gallstones induced by sex steroids in the female Syrian hamster: duration effects.
Publisher
An entity responsible for making the resource available
Journal of submicroscopic cytology and pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
Female; Time Factors; Animals; Body Weight; Lipids/blood; Organ Size; Cricetinae; Mesocricetus; Epithelium/drug effects/ultrastructure; Cholelithiasis/*chemically induced; Estradiol/*toxicity; Gallbladder/*drug effects/pathology; Medroxyprogesterone/*toxicity; Microscopy; Electron
Creator
An entity primarily responsible for making the resource
Karkare S; Gilloteaux J
Description
An account of the resource
Scanning (SEM), and transmission (TEM) electron microscopy were used and correlated to morphologically characterize changes induced in the gallbladder epithelium of female Syrian hamster in response to treatments with estradiol (E) alone, and estradiol with medroxyprogesterone (E + MP). Compared with control (C), the E- and E + MP-treated groups demonstrated alterations in the serum lipid profile as well as significantly decreased body weights. The liver with gallbladder weights, as well as the uterus weights, were significantly increased. Two-month E and E + MP treatment groups exhibited increased number of anionically charged apical granules, and luminal mucoid elements. Contrastingly, the three-month treatment groups demonstrated larger and more gallstone-like deposits as compared to the C and two-month E and E + MP groups. This report presents a comprehensive overview of our previous and current data, including that of other investigators in relation to the various factors and parameters involved in the cholelithiatic process.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Body Weight
Cholelithiasis/*chemically induced
Cricetinae
Electron
Epithelium/drug effects/ultrastructure
Estradiol/*toxicity
Female
Gallbladder/*drug effects/pathology
Gilloteaux J
Journal of submicroscopic cytology and pathology
Karkare S
Lipids/blood
Medroxyprogesterone/*toxicity
Mesocricetus
Microscopy
Organ Size
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00653.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00653.2016</a>
Pages
H541–H545
Issue
3
Volume
312
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.
Publisher
An entity responsible for making the resource available
American journal of physiology. Heart and circulatory physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
*Rats; Animal; Animals; Aortic Aneurysm; Atherosclerosis/pathology; Blood Glucose/metabolism; Blood Vessels/pathology; Body Weight; Collagen/biosynthesis; Cysts/*genetics/pathology; Disease Models; hypoxia; Hypoxia; Inbred Strains; leptin; Lipids/blood; Male; metabolic syndrome; Metabolic Syndrome/*genetics/pathology; Necrosis; Proteoglycans/biosynthesis; Rats; rodent model; Thoracic/*genetics/pathology
Creator
An entity primarily responsible for making the resource
Pung Yuh Fen; Chilian William M; Bennett Martin R; Figg Nichola; Kamarulzaman Mohd Hamzah
Description
An account of the resource
Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of the normal vessel wall has not been described. We examined JCR:LA control (+/+) or cp/cp rats fed normal chow diet for 6 or 18 mo. JCR:LA-cp rats developed multiple features of advanced cystic medial necrosis including "cysts," increased collagen formation and proteoglycan deposition around cysts, apoptosis of vascular smooth muscle cells, and spotty medial calcification. These appearances began within 6 mo and were extensive by 18 mo. JCR:LA-cp rats had reduced medial cellularity, increased medial thickness, and vessel hypoxia that was most marked in the adventitia. In conclusion, the normal chow-fed JCR:LA-cp rat represents a novel rodent model of cystic medial necrosis, associated with multiple metabolic abnormalities, vascular smooth muscle cell apoptosis, and vessel hypoxia.NEW & NOTEWORTHY Triggers for cystic medial necrosis (CMN) have been difficult to study due to lack of animal models to recapitulate the pathologies seen in humans. Our study is the first description of CMN in the rat. Thus the JCR:LA-cp rat represents a useful model to investigate the underlying molecular changes leading to the development of CMN.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00653.2016" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00653.2016</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Rats
2017
American journal of physiology. Heart and circulatory physiology
Animal
Animals
Aortic Aneurysm
Atherosclerosis/pathology
Bennett Martin R
Blood Glucose/metabolism
Blood Vessels/pathology
Body Weight
Chilian William M
Collagen/biosynthesis
Cysts/*genetics/pathology
Department of Integrative Medical Sciences
Disease Models
Figg Nichola
hypoxia
Inbred Strains
Kamarulzaman Mohd Hamzah
leptin
Lipids/blood
Male
Metabolic syndrome
Metabolic Syndrome/*genetics/pathology
Necrosis
NEOMED College of Medicine
Proteoglycans/biosynthesis
Pung Yuh Fen
Rats
rodent model
Thoracic/*genetics/pathology