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Text
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URL Address
<a href="http://doi.org/10.1016/j.ajpath.2016.05.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajpath.2016.05.006</a>
Pages
2417–2428
Issue
9
Volume
186
Dublin Core
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Title
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The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice.
Publisher
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The American journal of pathology
Date
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2016
2016-09
Subject
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Alcoholic/*metabolism; Animal; Animals; Blotting; Disease Models; Fatty Liver; Humans; Inbred C57BL; Knockout; Lipocalin-2/*metabolism; Mice; Polymerase Chain Reaction; Western
Creator
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Cai Yan; Jogasuria Alvin; Yin Huquan; Xu Ming-Jiang; Hu Xudong; Wang Jiayou; Kim Chunki; Wu Jiashin; Lee Kwangwon; Gao Bin; You Min
Description
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We have previously shown that the ethanol-mediated elevation of lipocaline-2 (LCN2) is closely associated with the development of alcoholic fatty liver disease (AFLD) in mice. Herein, we aimed to understand the functional significance of LCN2 induction by ethanol and to explore its underlying mechanisms. We evaluated the effects of LCN2 in an in vitro cellular alcoholic steatosis model and in an animal study using wild-type and LCN2 knockout mice fed for 4 weeks with an ethanol-supplemented Lieber-DeCarli diet. In the cellular model of alcoholic steatosis, recombinant LCN2 or overexpression of LCN2 exacerbated ethanol-induced fat accumulation, whereas knocking down LCN2 prevented steatosis in hepatocytes exposed to ethanol. Consistently, removal of LCN2 partially but significantly alleviated alcoholic fatty liver injury in mice. Mechanistically, LCN2 mediates detrimental effects of ethanol in the liver via disrupted multiple signaling pathways, including aberrant nicotinamide phosphoribosyltransferase-sirtuin 1 axis, perturbed endocrine metabolic regulatory fibroblast growth factor 15/19 signaling, and impaired chaperone-mediated autophagy. Finally, compared with healthy human livers, liver samples from patients with AFLD had lower gene expression of several
Identifier
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<a href="http://doi.org/10.1016/j.ajpath.2016.05.006" target="_blank" rel="noreferrer noopener">10.1016/j.ajpath.2016.05.006</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Alcoholic/*metabolism
Animal
Animals
Blotting
Cai Yan
Department of Pharmaceutical Sciences
Disease Models
Fatty Liver
Gao Bin
Hu Xudong
Humans
Inbred C57BL
Jogasuria Alvin
Kim Chunki
Knockout
Lee Kwangwon
Lipocalin-2/*metabolism
Mice
NEOMED College of Pharmacy
Polymerase Chain Reaction
The American journal of pathology
Wang Jiayou
Western
Wu Jiashin
Xu Ming-Jiang
Yin Huquan
You Min