1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hipo.450040602" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hipo.450040602</a>
Pages
623–634
Issue
6
Volume
4
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Multideterminant role of calcium in hippocampal synaptic plasticity.
Publisher
An entity responsible for making the resource available
Hippocampus
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-12
Subject
The topic of the resource
Animals; Calcium/*physiology; Hippocampus/drug effects/*physiology; Humans; Neuronal Plasticity/drug effects/*physiology; Synapses/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Teyler T J; Cavus I; Coussens C; DiScenna P; Grover L; Lee Y P; Little Z
Description
An account of the resource
Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca(2+)-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/hipo.450040602" target="_blank" rel="noreferrer noopener">10.1002/hipo.450040602</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Animals
Calcium/*physiology
Cavus I
Coussens C
DiScenna P
Grover L
Hippocampus
Hippocampus/drug effects/*physiology
Humans
Lee Y P
Little Z
Neuronal Plasticity/drug effects/*physiology
Synapses/drug effects/*physiology
Teyler T J
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
73–76
Issue
1
Volume
201
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
Animals; Rats; Electric Stimulation; In Vitro Techniques; Electrophysiology; Excitatory Amino Acid Antagonists/*pharmacology; Long-Term Potentiation/*drug effects; Hippocampus/drug effects/*physiology; Benzoates/*pharmacology; Calcium Channels/drug effects/metabolism/physiology; Glycine/*analogs & derivatives/pharmacology; Ion Channel Gating/drug effects; Receptors; Metabotropic Glutamate/*antagonists & inhibitors
Creator
An entity primarily responsible for making the resource
Little Z; Grover L M; Teyler T J
Description
An account of the resource
The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two independent forms of LTP. One form induced by a 25 Hz/1 s tetanus is solely N-methyl-D-aspartate (NMDA) receptor-dependent. The other form induced by four 200 Hz/0.5 s bursts in the presence of APV is NMDA receptor-independent. In both paradigms the presence of MCPG prevented the induction of LTP by afferent activation.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Benzoates/*pharmacology
Calcium Channels/drug effects/metabolism/physiology
Electric Stimulation
Electrophysiology
Excitatory Amino Acid Antagonists/*pharmacology
Glycine/*analogs & derivatives/pharmacology
Grover L M
Hippocampus/drug effects/*physiology
In Vitro Techniques
Ion Channel Gating/drug effects
Little Z
Long-Term Potentiation/*drug effects
Metabotropic Glutamate/*antagonists & inhibitors
Neuroscience letters
Rats
Receptors
Teyler T J