1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.490430109" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.490430109</a>
Pages
71–77
Issue
1
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alteration of dopamine release by rat caudate putamen tissues superfused with alpha 2-macroglobulin.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-01
Subject
The topic of the resource
alpha-Macroglobulins/drug effects/*pharmacology/physiology; Alzheimer Disease/metabolism; Animals; Caudate Nucleus/*drug effects/metabolism; Chemical; Dopamine/*metabolism; Male; Methylamines/pharmacology; Nerve Growth Factor/physiology; Nerve Growth Factors/physiology; Neurotoxins/*pharmacology; Parkinson Disease/metabolism; Perfusion; Putamen/*drug effects/metabolism; Rats; Receptors; Sprague-Dawley; Stimulation
Creator
An entity primarily responsible for making the resource
Hu Y Q; Liu B J; Dluzen D E; Koo P H
Description
An account of the resource
Monoamine-activated alpha-2-macroglobulin (alpha 2M) has been shown to decrease the dopamine concentrations in rat caudate putamen (CP) in vivo as well as inhibit choline acetyltransferase activities in the culture of basal forebrain neurons. In this study, we further investigated the effects of methylamine-activated alpha 2M (MA-alpha 2M) upon striatal dopaminergic function by determining whether a direct infusion of this glycoprotein will alter dopamine (DA) release in vitro from superfused CP tissue fragments. In experiment 1, an infusion of 2.8 microM MA-alpha 2M produced a statistically significant increase in DA release compared with control superfusions. In experiment 2, varying doses (0, 0.7, 1.4, 2.8, 4.1 microM) of MA-alpha 2M were tested for their capacity to alter DA release. Only the 2.8 microM dose of MA-alpha 2M was effective in producing a significant increase of DA release. In experiment 3, the normal form of alpha 2M (N-alpha 2M) at 2.8 microM was compared with the control superfusions. The infusion of N-alpha 2M produced an increase in DA release which was substantially lower than the DA increase induced by MA-alpha 2M, and not significantly different from that of the control superfusion. These results show that MA-alpha 2M, like some other neurotoxins, can markedly alter CP dopaminergic function as indicated by the acute increase in DA release following infusion of this glycoprotein, and these effects are exerted at a relatively narrow range of doses. Taken together, these data suggest that this glycoprotein, if allowed to accumulate in the central nervous system (CNS), may promote some neurodegenerative changes that can occur in disorders like Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.490430109" target="_blank" rel="noreferrer noopener">10.1002/jnr.490430109</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
alpha-Macroglobulins/drug effects/*pharmacology/physiology
Alzheimer Disease/metabolism
Animals
Caudate Nucleus/*drug effects/metabolism
Chemical
Dluzen D E
Dopamine/*metabolism
Hu Y Q
Journal of neuroscience research
Koo P H
Liu B J
Male
Methylamines/pharmacology
Nerve Growth Factor/physiology
Nerve Growth Factors/physiology
Neurotoxins/*pharmacology
Parkinson Disease/metabolism
Perfusion
Putamen/*drug effects/metabolism
Rats
Receptors
Sprague-Dawley
Stimulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/hbeh.1994.1002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/hbeh.1994.1002</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
16-28
Issue
1
Volume
28
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Title
A name given to the resource
EFFECTS OF ESTROGEN-TREATMENT ON SENSORIMOTOR TASK-PERFORMANCE AND BRAIN DOPAMINE CONCENTRATIONS IN GONADECTOMIZED MALE AND FEMALE CD-1 MICE
Publisher
An entity responsible for making the resource available
Hormones and Behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-03
Subject
The topic of the resource
Endocrinology & Metabolism; parkinsons-disease; Behavioral Sciences; Sensitivity; striatum; amphetamine; sex-differences; estradiol; release; locomotor-activity; castrated male-rats; rotational behavior
Creator
An entity primarily responsible for making the resource
McDermott J L; Kreutzberg J D; Liu B J; Dluzen D E
Description
An account of the resource
In Experiment I, castrated male and female CD-1 mice +/- estradiol benzoate (EB) treatment were tested for their performance on a skilled sensorimotor task consisting of walking across beams of varying widths (6, 9, 12, and 21 mm). To evaluate whether behavioral performance was related to nigrostriatal dopaminergic function, tissue dopamine concentrations were determined from the corpus striatum as well as the hypothalamus and olfactory tubercle. In general, sensorimotor performance improved for all treatment conditions as the beam width increased. Castrated male mice treated with oil vehicle showed the worst performance as indicated by significantly greater amounts of time to cross the beam. Treatment of castrated males with EB significantly improved their performance. Performance of the castrated females was not changed by EB treatment and was similar to that observed with the castrated + EB males. Significant gender differences in dopamine concentrations (female > male) were obtained in the corpus striatum, as well as the olfactory tubercle and hypothalamus. Dopamine levels were unaltered by EB treatment. In Experiment II, behavioral and neurochemical determinations were directly compared between castrated and intact male mice. Behavioral performance of castrates was significantly reduced compared to intact males. No differences in dopamine concentrations were obtained between these two groups; however, the hypothalamic dopamine/DOPAC ratio of castrates was significantly greater than that of intact male mice. These results demonstrate significant modulatory effects of EB in castrated male, but not female, mice upon sensorimotor performance and indicate that this task may provide an effective means to partial out modulatory effects of gonadal steroid hormones upon skilled sensorimotor performance. When the data of Experiments I and II are combined, it appears that the basis of this sensorimotor deficit in the males is the absence of gonadal steroid hormones. In addition, these results reveal significant gender differences in various dopaminergic systems in these mice. (C) 1994 Academic Press, Inc.
Identifier
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<a href="http://doi.org/10.1006/hbeh.1994.1002" target="_blank" rel="noreferrer noopener">10.1006/hbeh.1994.1002</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
amphetamine
Behavioral Sciences
castrated male-rats
Dluzen D E
Endocrinology & Metabolism
estradiol
Hormones and Behavior
Journal Article or Conference Abstract Publication
Kreutzberg J D
Liu B J
locomotor-activity
McDermott J L
parkinsons-disease
release
rotational behavior
sensitivity
sex-differences
striatum
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)00993-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)00993-z</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
248-252
Issue
1
Volume
698
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Title
A name given to the resource
TAMOXIFEN TREATMENT OF OVARIECTOMIZED MICE ALTERS DOPAMINE RELEASE FROM STRIATAL TISSUE FRAGMENTS SUPERFUSED IN-VITRO
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-11
Subject
The topic of the resource
rat; therapy; Neurosciences & Neurology; estrogen; metabolism; brain; breast-cancer; estradiol; nigrostriatal; pituitary; antiestrogens; uterus; anti-estrogen; caudate nucleus
Creator
An entity primarily responsible for making the resource
McDermott J L; Liu B J; Dluzen D E
Description
An account of the resource
In this report we examined the effect of tamoxifen upon the nigrostriatal dopaminergic system. Ovariectomized mice were subjected to one of the following treatments: two subcutaneous injections administered on successive days of the sesame oil vehicle (control), estradiol benzoate (EB-10 mu g), tamoxifen citrate (TMX 125 mu g) or a combination of EB + TMX. At 24 h after the second injection, the caudate nucleus was superfused in vitro to evaluate the effects of these treatments upon basal as well as potassium stimulated (30 mM) dopamine release rates. In addition, uteri were weighed from each animal. Basal and total fractional dopamine release rates from the caudate nucleus of control mice were significantly lower than those of the other three treatments, which failed to differ among each other. Potassium minus(-) basal stimulated dopamine release rates failed to differ significantly among the four treatment conditions. Uterine weights of the TMX treated mice were significantly greater than controls, but significantly lower than EB and EB + TMX animals. These data show that TMX can significantly increase caudate nucleus dopamine release to levels observed in EB treated mice. These agonistic effects of TMX upon nigrostriatal dopaminergic function can be contrasted with its relatively weak estrogenic effects upon uterine weights and indicate the discriminatory, system specific effects that can be exerted by this anti-estrogen. This demonstration of TMX's ability to modulate central nervous system function is of particular relevance in light of pending clinical trials for the prophylactic use of TMX in the treatment of women for breast cancer.
Identifier
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<a href="http://doi.org/10.1016/0006-8993(95)00993-z" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)00993-z</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
anti-estrogen
antiestrogens
Brain
Brain research
breast-cancer
caudate nucleus
Dluzen D E
estradiol
estrogen
Journal Article or Conference Abstract Publication
Liu B J
McDermott J L
Metabolism
Neurosciences & Neurology
nigrostriatal
pituitary
rat
therapy
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1994.62010094.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1994.62010094.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
94-101
Issue
1
Volume
62
Search for Full-text
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Dublin Core
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Title
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Modulatory Effects Of Testosterone On 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity
Publisher
An entity responsible for making the resource available
Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
1-methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine; aged rats; amphetamine; Biochemistry & Molecular Biology; castrated male-rats; corpus striatum; dopamine; dopamine release invitro; estrogen-treatment; l-dopa; mice; Neurosciences & Neurology; parkinsons-disease; rotational behavior; sex-differences; steroid-hormones; testosterone
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1994.62010094.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1994.62010094.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine
aged rats
amphetamine
Biochemistry & Molecular Biology
castrated male-rats
corpus striatum
Dluzen D
Dopamine
dopamine release invitro
estrogen-treatment
Jain R
Journal of neurochemistry
l-dopa
Liu B J
Mice
Neurosciences & Neurology
parkinsons-disease
rotational behavior
sex-differences
steroid-hormones
Testosterone