1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2014/769515" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2014/769515</a>
Pages
1–9
Volume
2014
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload.
Publisher
An entity responsible for making the resource available
Evidence-based Complementary & Alternative Medicine (eCAM)
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-01
Subject
The topic of the resource
Mice; Gene Expression Profiling; Signal Transduction; Echocardiography; Staining and Labeling; Descriptive Statistics; Funding Source; Post Hoc Analysis; One-Way Analysis of Variance; T-Tests; Blotting; Western; Animal Studies; In Vivo Studies; Vasoconstriction; Phosphorylation – Drug Effects; Aorta – Physiopathology; Heart Diseases – Prevention and Control; Hypertrophy – Prevention and Control; Plant Extracts – Therapeutic Use; Protein Kinases – Antagonists and Inhibitors
Creator
An entity primarily responsible for making the resource
Qi Jianyong; Liu Qin; Gong Kaizheng; Yu Juan; Wang Lei; Guo Liheng; Zhou Miao; Wu Jiashin; Zhang Minzhou
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2014/769515" target="_blank" rel="noreferrer noopener">10.1155/2014/769515</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animal Studies
Aorta – Physiopathology
Blotting
Descriptive Statistics
Echocardiography
Evidence-based Complementary & Alternative Medicine (eCAM)
Funding Source
Gene Expression Profiling
Gong Kaizheng
Guo Liheng
Heart Diseases – Prevention and Control
Hypertrophy – Prevention and Control
In Vivo Studies
Liu Qin
Mice
One-Way Analysis of Variance
Phosphorylation – Drug Effects
Plant Extracts – Therapeutic Use
Post Hoc Analysis
Protein Kinases – Antagonists and Inhibitors
Qi Jianyong
Signal Transduction
Staining and Labeling
T-Tests
Vasoconstriction
Wang Lei
Western
Wu Jiashin
Yu Juan
Zhang Minzhou
Zhou Miao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2014/769515" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2014/769515</a>
Pages
769515–769515
Volume
2014
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload.
Publisher
An entity responsible for making the resource available
Evidence-based complementary and alternative medicine : eCAM
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Creator
An entity primarily responsible for making the resource
Qi Jianyong; Liu Qin; Gong Kaizheng; Yu Juan; Wang Lei; Guo Liheng; Zhou Miao; Wu Jiashin; Zhang Minzhou
Description
An account of the resource
Background. Cardiac hypertrophy occurs in many cardiovascular diseases. Apocynum tablet (AT), a traditional Chinese medicine, has been widely used in China to treat patients with hypertension. However, the underlying molecular mechanisms of AT on the hypertension-induced cardiac hypertrophy remain elusive. The current study evaluated the effect and mechanisms of AT on cardiac hypertrophy. Methods. We created a mouse model of cardiac hypertrophy by inducing pressure overload with surgery of transverse aortic constriction (TAC) and then explored the effect of AT on the development of cardiac hypertrophy using 46 mice in 4 study groups (combinations of AT and TAC). In addition, we evaluated the signaling pathway of phosphorylation of ERK1/2, AKT, and protein expression of GATA4 in the cardioprotective effects of AT using Western blot. Results. AT inhibited the phosphorylation of Thr202/Tyr204 sites of ERK1/2, Ser473 site of AKT, and protein expression of GATA4 and significantly inhibited cardiac hypertrophy and cardiac fibrosis at 2 weeks after TAC surgery (P \textless 0.05). Conclusions. We experimentally demonstrated that AT inhibits cardiac hypertrophy via suppressing phosphorylation of ERK1/2 and AKT.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2014/769515" target="_blank" rel="noreferrer noopener">10.1155/2014/769515</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Evidence-based complementary and alternative medicine : eCAM
Gong Kaizheng
Guo Liheng
Liu Qin
Qi Jianyong
Wang Lei
Wu Jiashin
Yu Juan
Zhang Minzhou
Zhou Miao
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/srep42843" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/srep42843</a>
Pages
42843–42843
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanisms of Chinese Medicine Xinmailong's protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes.
Publisher
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Scientific reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-02
Subject
The topic of the resource
Animal; Animals; Cardiac/cytology/*drug effects/metabolism; Cell Nucleus/metabolism; Cell Survival/drug effects; Cells; Chinese Herbal/*administration & dosage/pharmacology; Constriction; Cultured; Disease Models; Drugs; Echocardiography; GABA Plasma Membrane Transport Proteins/*metabolism; Gene Expression Regulation/drug effects; Glycogen Synthase Kinase 3 beta/metabolism; Heart Failure/etiology/metabolism/physiopathology/*prevention & control; Humans; MAP Kinase Signaling System/drug effects; Mice; Myocytes; Pathologic; Phosphorylation; Proto-Oncogene Proteins c-akt/metabolism; Rats
Creator
An entity primarily responsible for making the resource
Qi Jianyong; Yu Juan; Tan Yafang; Chen Renshan; Xu Wen; Chen Yanfen; Lu Jun; Liu Qin; Wu Jiashin; Gu Weiwang; Zhang Minzhou
Description
An account of the resource
Patients with heart failure (HF) have high mortality and mobility. Xinmailong (XML) injection, a Chinese Medicine, is clinically effective in treating HF. However, the mechanism of XML's effectiveness on HF was unclear, and thus, was the target of the present study. We created a mouse model of pressure-overload-induced HF with transverse aortic constriction (TAC) surgery and compared among 4 study groups: SHAM (n = 10), TAC (n = 12), MET (metoprolol, positive drug treatment, n = 7) and XML (XML treatment, n = 14). Dynamic changes in cardiac structure and function were evaluated with echocardiography in vivo. In addition, H9C2 rat cardiomyocytes were cultured in vitro and the phosphorylation of ERK1/2, AKT, GSK3beta and protein expression of GATA4 in nucleus were detected with Western blot experiment. The results showed that XML reduced diastolic thickness of left ventricular posterior wall, increased ejection fraction and fraction shortening, so as to inhibit HF at 2 weeks after TAC. Moreover, XML inhibited the phosphorylation of ERK1/2, AKT and GSK3beta, subsequently inhibiting protein expression of GATA4 in nucleus (P \textless 0.001). Together, our data demonstrated that XML inhibited the TAC-induced HF via inactivating the ERK1/2, AKT/GSK3beta, and GATA4 signaling pathway.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/srep42843" target="_blank" rel="noreferrer noopener">10.1038/srep42843</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Animal
Animals
Cardiac/cytology/*drug effects/metabolism
Cell Nucleus/metabolism
Cell Survival/drug effects
Cells
Chen Renshan
Chen Yanfen
Chinese Herbal/*administration & dosage/pharmacology
Constriction
Cultured
Disease Models
Drugs
Echocardiography
GABA Plasma Membrane Transport Proteins/*metabolism
Gene Expression Regulation/drug effects
Glycogen Synthase Kinase 3 beta/metabolism
Gu Weiwang
Heart Failure/etiology/metabolism/physiopathology/*prevention & control
Humans
Liu Qin
Lu Jun
MAP Kinase Signaling System/drug effects
Mice
Myocytes
Pathologic
Phosphorylation
Proto-Oncogene Proteins c-akt/metabolism
Qi Jianyong
Rats
Scientific reports
Tan Yafang
Wu Jiashin
Xu Wen
Yu Juan
Zhang Minzhou