1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fncir.2014.00051" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2014.00051</a>
Pages
51–51
Volume
8
Dublin Core
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Title
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Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.
Publisher
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Frontiers in neural circuits
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
Animals; IPSC; Chick Embryo; Patch-Clamp Techniques; Neurons/*physiology; Auditory Pathways/*physiology; GABAergic inhibition; Inhibitory Postsynaptic Potentials/*physiology; interaural time difference; IPSP; Sound Localization/physiology; Synaptic Transmission/*physiology; tonotopy; voltage-gated low-threshold potassium current; whole-cell patch; Potassium Channels; Voltage-Gated/*physiology
Creator
An entity primarily responsible for making the resource
Hamlet William R; Liu Yu-Wei; Tang Zheng-Quan; Lu Yong
Description
An account of the resource
Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between intrinsic voltage-gated conductances and extrinsic synaptic conductances in determining neuronal output are not well understood. In chicken, neurons in the nucleus laminaris (NL) encode sound location using interaural time difference (ITD) as a cue. Along the tonotopic axis of NL, there exist robust differences among low, middle, and high frequency (LF, MF, and HF, respectively) neurons in a variety of neuronal properties such as low threshold voltage-gated K(+) (LTK) channels and depolarizing inhibition. This establishes NL as an ideal model to examine the interactions between LTK currents and synaptic inhibition across the tonotopic axis. Using whole-cell patch clamp recordings prepared from chicken embryos (E17-E18), we found that LTK currents were larger in MF and HF neurons than in LF neurons. Kinetic analysis revealed that LTK currents in MF neurons activated at lower voltages than in LF and HF neurons, whereas the inactivation of the currents was similar across the tonotopic axis. Surprisingly, blockade of LTK currents using dendrotoxin-I (DTX) tended to broaden the duration and increase the amplitude of the depolarizing inhibitory postsynaptic potentials (IPSPs) in NL neurons without dependence on coding frequency regions. Analyses of the effects of DTX on inhibitory postsynaptic currents led us to interpret this unexpected observation as a result of primarily postsynaptic effects of LTK currents on MF and HF neurons, and combined presynaptic and postsynaptic effects in LF neurons. Furthermore, DTX transferred subthreshold IPSPs to spikes. Taken together, the results suggest a critical role for LTK currents in regulating inhibitory synaptic strength in ITD-coding neurons at various frequencies.
Identifier
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<a href="http://doi.org/10.3389/fncir.2014.00051" target="_blank" rel="noreferrer noopener">10.3389/fncir.2014.00051</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Auditory Pathways/*physiology
Chick Embryo
Department of Anatomy & Neurobiology
Frontiers in neural circuits
GABAergic inhibition
Hamlet William R
Inhibitory Postsynaptic Potentials/*physiology
interaural time difference
IPSC
IPSP
Liu Yu-Wei
Lu Yong
NEOMED College of Medicine
Neurons/*physiology
Patch-Clamp Techniques
Potassium Channels
Sound Localization/physiology
Synaptic Transmission/*physiology
Tang Zheng-Quan
tonotopy
voltage-gated low-threshold potassium current
Voltage-Gated/*physiology
whole-cell patch
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0202-13.2013</a>
Pages
15964–15977
Issue
40
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.
Publisher
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
Animals; Chick Embryo; Synaptic Transmission/drug effects/*physiology; Excitatory Amino Acid Antagonists/pharmacology; Amino Acids/pharmacology; Cochlear Nucleus/drug effects/metabolism; Cyclopropanes/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; GABAergic Neurons/drug effects/*metabolism; Glycine/analogs & derivatives/pharmacology; Inhibitory Postsynaptic Potentials/drug effects/physiology; Long-Term Synaptic Depression/drug effects/*physiology; Neural Inhibition/drug effects/physiology; Synapses/drug effects/*metabolism; Xanthenes/pharmacology; Receptors; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
Creator
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Tang Zheng-Quan; Liu Yu-Wei; Shi Wei; Dinh Emilie Hoang; Hamlet William R; Curry Rebecca J; Lu Yong
Description
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Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory synapses. Here we report that pharmacological or synaptic activation of group II mGluRs (mGluR II) induces LTD at GABAergic synapses without affecting the excitatory glutamatergic transmission in neurons of the chicken cochlear nucleus. Coefficient of variation and failure rate analysis suggested that the LTD was expressed presynaptically. The LTD requires presynaptic spike activity, but does not require the activation of NMDA receptors. The classic cAMP-dependent protein kinase A signaling is involved in the transduction pathway. Remarkably, blocking mGluR II increased spontaneous GABA release, indicating the presence of tonic activation of mGluR II by ambient glutamate. Furthermore, synaptically released glutamate induced by electrical stimulations that concurrently activated both the glutamatergic and GABAergic pathways resulted in significant and constant suppression of GABA release at various stimulus frequencies (3.3, 100, and 300 Hz). Strikingly, low-frequency stimulation (1 Hz, 15 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LTD was blocked by mGluR II antagonist, indicating that synaptic activation of mGluR II induced the LTD. This novel form of long-term plasticity in the avian auditory brainstem may play a role in the development as well as in temporal processing in the sound localization circuit.
Identifier
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<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0202-13.2013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Amino Acids/pharmacology
Animals
Chick Embryo
Cochlear Nucleus/drug effects/metabolism
Curry Rebecca J
Cyclopropanes/pharmacology
Department of Anatomy & Neurobiology
Dinh Emilie Hoang
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
GABAergic Neurons/drug effects/*metabolism
Glycine/analogs & derivatives/pharmacology
Hamlet William R
Inhibitory Postsynaptic Potentials/drug effects/physiology
Liu Yu-Wei
Long-Term Synaptic Depression/drug effects/*physiology
Lu Yong
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Receptors
Shi Wei
Synapses/drug effects/*metabolism
Synaptic Transmission/drug effects/*physiology
Tang Zheng-Quan
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xanthenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1113/JP275735" target="_blank" rel="noreferrer noopener">http://doi.org/10.1113/JP275735</a>
Pages
1981–1997
Issue
10
Volume
596
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.
Publisher
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The Journal of physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-05
Subject
The topic of the resource
EPSC; mGluR; neuromodulation; synaptic integration
Creator
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Lu Yong; Liu Yu-Wei; Curry Rebecca J
Description
An account of the resource
KEY POINTS: Binaural excitatory inputs to coincidence detection neurons in nucleus laminaris (NL) play essential roles in interaural time difference coding for sound localization. Here, we show that the two excitatory inputs are physiologically nearly completely segregated. Synaptic integration shows linear summation of EPSPs, ensuring high efficiency of coincidence detection of the bilateral excitatory inputs. We further show that the two excitatory inputs to single NL neurons are symmetrical in synaptic strength, kinetics and short-term plasticity. Modulation of the EPSCs by metabotropic glutamate receptors (mGluRs) is identical between the two excitatory inputs, maintaining balanced bilateral excitation under neuromodulatory conditions. Unilateral hearing deprivation reduces synaptic excitation and paradoxically strengthens mGluR modulation of EPSCs, suggesting activity-dependent anti-homeostatic regulation, a novel synaptic plasticity in response to sensory manipulations. ABSTRACT: Neurons in the avian nucleus laminaris (NL) receive bilateral excitatory inputs from the cochlear nucleus magnocellularis, via morphologically symmetrical dorsal (ipsilateral) and ventral (contralateral) dendrites. Using in vitro whole-cell patch recordings in chicken brainstem slices, we investigated synaptic integration and modulation of the bilateral inputs to NL under normal and hearing deprivation conditions. We found that the two excitatory inputs onto single NL neurons were nearly completely segregated, and integration of the two inputs was linear for EPSPs. The two inputs had similar synaptic strength, kinetics and short-term plasticity. EPSCs in low but not middle and high frequency neurons were suppressed by activation of group I and II metabotropic glutamate receptors (mGluR I and II), with similar modulatory strength between the ipsilateral and contralateral inputs. Unilateral hearing deprivation by cochlea removal reduced the excitatory transmission on the deprived dendritic domain of NL. Interestingly, EPSCs evoked at the deprived domain were modulated more strongly by mGluR II than at the counterpart domain that received intact input in low frequency neurons, suggesting anti-homeostatic regulation. This was supported by a stronger expression of mGluR II protein on the deprived neuropils of NL. Under mGluR II modulation, EPSCs on the deprived input show transient synaptic facilitation, forming a striking contrast with normal hearing conditions under which pure synaptic depression is observed. These results demonstrate physiological symmetry and thus balanced bilateral excitatory inputs to NL neurons. The activity-dependent anti-homeostatic plasticity of mGluR modulation constitutes a novel mechanism regulating synaptic transmission in response to sensory input manipulations.
Identifier
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<a href="http://doi.org/10.1113/JP275735" target="_blank" rel="noreferrer noopener">10.1113/JP275735</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Curry Rebecca J
Department of Anatomy & Neurobiology
EPSC
Liu Yu-Wei
Lu Yong
mGluR
NEOMED College of Medicine
neuromodulation
synaptic integration
The Journal of physiology