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Text
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URL Address
<a href="http://doi.org/10.2174/187152010791162252" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/187152010791162252</a>
Pages
338–345
Issue
4
Volume
10
Dublin Core
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Title
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Selenium in the prevention and treatment of hepatocellular carcinoma.
Publisher
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Anti-cancer agents in medicinal chemistry
Date
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2010
2010-05
Subject
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Humans; Animals; Oxidative Stress; Anticarcinogenic Agents/*therapeutic use; Liver Neoplasms/chemically induced/*drug therapy/etiology/*prevention & control; Selenium/*therapeutic use; Carcinoma; Models; Animal; Hepatocellular/chemically induced/*drug therapy/etiology/*prevention & control
Creator
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Darvesh Altaf S; Bishayee Anupam
Description
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Hepatocellular carcinoma (HCC) happens to be one of the most lethal cancers in the world. Even though most cases occur in the developing world, reported cases in Western Europe as well as North America are on a steep rise. Human HCC etiology includes chronic liver disease, viral hepatitis, alcoholism, iron overload as well as dietary carcinogens such as aflatoxins and nitrosoamines. Surgical resection as well as liver transplants, which are currently used to treat HCC, is mostly ineffective. Consequently, there exists a decisive requirement to explore possible alternative chemopreventive and therapeutic strategies for HCC. Both oxidative stress and inflammatory mechanisms have been implicated in the pathophysiology of HCC. The use of dietary antioxidants and micronutrients has been proposed as an effective means for successful management of human HCC. Trace elements such as vanadium and selenium are involved in several major metabolic pathways as well as antioxidant defense systems. Selenium has been shown to be involved in the prevention of numerous chronic illnesses such as several specific cancers and neurodegenerative diseases. This review examines the potential role of selenium in the prevention and treatment of HCC. The in vivo and in vitro effects of selenium and the mechanisms involved in preclinical models of liver cancer are critically reviewed in this article. The chemopreventive and therapeutic effects of selenium are reviewed especially in relation to its antioxidant property. Future directions and potential challenges involved in the advance of selenium use in the prevention and treatment of liver cancer are also discussed.
Identifier
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<a href="http://doi.org/10.2174/187152010791162252" target="_blank" rel="noreferrer noopener">10.2174/187152010791162252</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Animal
Animals
Anti-cancer agents in medicinal chemistry
Anticarcinogenic Agents/*therapeutic use
Bishayee Anupam
Carcinoma
Darvesh Altaf S
Department of Pharmaceutical Sciences
Hepatocellular/chemically induced/*drug therapy/etiology/*prevention & control
Humans
Liver Neoplasms/chemically induced/*drug therapy/etiology/*prevention & control
Models
NEOMED College of Pharmacy
Oxidative Stress
Selenium/*therapeutic use