1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s11095-010-0144-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11095-010-0144-4</a> Pages 1080–1091 Issue 6 Volume 27 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis. Publisher An entity responsible for making the resource available Pharmaceutical research Date A point or period of time associated with an event in the lifecycle of the resource 2010 2010-06 Subject The topic of the resource Animals; Anticarcinogenic Agents/*therapeutic use; Chemoprevention; Cyclooxygenase 2/immunology; Diethylnitrosamine; Female; HSP70 Heat-Shock Proteins/immunology; Humans; Inflammation/prevention & control; Liver Neoplasms/chemically induced/*immunology/*prevention & control; Liver/drug effects/pathology; NF-kappa B/immunology; Rats; Resveratrol; Sprague-Dawley; Stilbenes/*therapeutic use Creator An entity primarily responsible for making the resource Bishayee Anupam; Waghray Abhijeet; Barnes Kendra F; Mbimba Thomas; Bhatia Deepak; Chatterjee Malay; Darvesh Altaf S Description An account of the resource PURPOSE: Resveratrol, present in grapes and red wine, has been found to prevent diethylnitrosamine (DENA)-initiated rat liver tumorigenesis, though the chemopreventive mechanisms are not completely elucidated. The current study was designed to explore whether the antiinflammatory properties of resveratrol play a role in its antihepatocarcinogenic action. METHODS: Liver samples were harvested from a 20-week chemopreventive study in which resveratrol (50, 100 and 300 mg/kg) was shown to inhibit DENA-induced hepatocyte nodules in Sprague-Dawley rats in a dose-responsive manner. Hepatic preneoplastic and inflammatory markers, namely heat shock protein (HSP70), cyclooxygenase-2 (COX-2) and nuclear factor-kappaB (NF-kappaB), were studied using immunohistochemical as well as Western blot techniques. RESULTS: Resveratrol dose-dependently suppressed DENA-induced increased expressions of hepatic HSP70 and COX-2. Resveratrol also attenuated the Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s11095-010-0144-4" target="_blank" rel="noreferrer noopener">10.1007/s11095-010-0144-4</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2010 Animals Anticarcinogenic Agents/*therapeutic use Barnes Kendra F Bhatia Deepak Bishayee Anupam Chatterjee Malay Chemoprevention Cyclooxygenase 2/immunology Darvesh Altaf S Department of Pharmaceutical Sciences Diethylnitrosamine Female HSP70 Heat-Shock Proteins/immunology Humans Inflammation/prevention & control Liver Neoplasms/chemically induced/*immunology/*prevention & control Liver/drug effects/pathology Mbimba Thomas NEOMED College of Pharmacy NF-kappa B/immunology Pharmaceutical research Rats Resveratrol Sprague-Dawley Stilbenes/*therapeutic use Waghray Abhijeet