1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/icb.2014.60" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/icb.2014.60</a>
Pages
837–850
Issue
10
Volume
92
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Members of the novel UBASH3/STS/TULA family of cellular regulators suppress
Publisher
An entity responsible for making the resource available
Immunology and cell biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-11
Subject
The topic of the resource
Animals; Antigen; Colitis/*immunology; Humans; Knockout; Mice; Phosphorylation; Protein Tyrosine Phosphatases/genetics/*physiology; Receptors; T-Cell/genetics/*physiology; T-Lymphocytes/*immunology; ZAP-70 Protein-Tyrosine Kinase/metabolism
Creator
An entity primarily responsible for making the resource
Newman Tiffanny N; Liverani Elisabetta; Ivanova Elitza; Russo Gian L; Carpino Nick; Ganea Doina; Safadi Fayez; Kunapuli Satya P; Tsygankov Alexander Y
Description
An account of the resource
The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates. TULA-family proteins act as downregulators of receptor-induced activation in several cell types, including T cells and platelets. Deletion of both family members in mice has been shown to result in hyperresponsiveness of T cells to T-cell receptor (TCR)/CD3 complex engagement, but little is known about the biological consequences of double knockout (dKO) and especially of either single KO (sKO). We elucidated the biological consequences of the lack of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/icb.2014.60" target="_blank" rel="noreferrer noopener">10.1038/icb.2014.60</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Antigen
Carpino Nick
Colitis/*immunology
Department of Anatomy & Neurobiology
Ganea Doina
Humans
Immunology and cell biology
Ivanova Elitza
Knockout
Kunapuli Satya P
Liverani Elisabetta
Mice
NEOMED College of Medicine
Newman Tiffanny N
Phosphorylation
Protein Tyrosine Phosphatases/genetics/*physiology
Receptors
Russo Gian L
Safadi Fayez
T-Cell/genetics/*physiology
T-Lymphocytes/*immunology
Tsygankov Alexander Y
ZAP-70 Protein-Tyrosine Kinase/metabolism