1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1185/030079904x2556" target="_blank" rel="noreferrer noopener">http://doi.org/10.1185/030079904x2556</a>
Pages
1473–1481
Issue
9
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical implications of 750 mg, 5-day levofloxacin for the treatment of community-acquired pneumonia.
Publisher
An entity responsible for making the resource available
Current Medical Research & Opinion
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-09
Subject
The topic of the resource
Adult; Female; Male; Human; Chi Square Test; Funding Source; Retrospective Design; T-Tests; Kaplan-Meier Estimator; Random Assignment; McNemar's Test; Double-Blind Studies; Log-Rank Test; Pneumonia – Drug Therapy; Community-Acquired Infections – Drug Therapy; Ofloxacin – Administration and Dosage
Creator
An entity primarily responsible for making the resource
File T M Jr; Milkovich G; Tennenberg AM; Xiang JX; Khashab MM; Zadeikis N
Description
An account of the resource
OBJECTIVE: To evaluate the time to symptom resolution and i.v.-to-p.o. transition in community-acquired pneumonia (CAP) patients treated with 750 mg or 500 mg levofloxacin. RESEARCH DESIGN: A retrospective, subset analysis of a multicenter, randomized, double-blind, controlled trial comparing 750 mg levofloxacin for 5 days to 500 mg levofloxacin for 10 days for the treatment of CAP. PATIENTS AND METHODS: A total of 528 CAP patients were included. Baseline symptoms were re-evaluated on Day 3 of therapy, and time to i.v.-to-p.o. transition was recorded for inpatients. RESULTS: For the overall population, 67.4% of patients receiving 750 mg levofloxacin had resolution of fever by Day 3 of therapy, compared to 54.6% of 500 mg treated patients (P = 0.006). Patients who started on 750 mg levofloxacin i.v. (N = 108) transitioned to p.o. in an average of 2.68 days while those starting on 500 mg i.v. (N = 124) transitioned in 2.95 days (P = 0.144). The median time for i.v.-to-p.o. switch was 2.35 days and 2.75 days for patients receiving 750 mg and 500 mg levofloxacin, respectively (P = 0.098, log rank test). By Day 3 of therapy, 68% of patients receiving the 750 mg dose had transitioned from i.v. to p.o. levofloxacin, compared with 61% of the 500 mg group (P = 0.280). The safety profiles were comparable for the two regimens. CONCLUSIONS: The 750 mg levofloxacin dose resulted in a greater proportion of patients with resolution of CAP symptoms by Day 3 when compared with 500 mg therapy. Consequently, the 750 mg regimen trended toward more rapid transition to p.o., potentially resulting in lower overall drug costs. Time to switch from i.v. to p.o. was determined by the investigators' discretion rather than a set protocol. Additionally, length of stay data was not collected in this study, which can significantly impact overall healthcare costs. Further research is required to fully understand the economic impact of the 750 mg, 5-day levofloxacin regimen.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1185/030079904x2556" target="_blank" rel="noreferrer noopener">10.1185/030079904x2556</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Adult
Chi Square Test
Community-Acquired Infections – Drug Therapy
Current Medical Research & Opinion
Department of Internal Medicine
Double-Blind Studies
Female
File T M Jr
Funding Source
Human
Kaplan-Meier Estimator
Khashab MM
Log-Rank Test
Male
McNemar's Test
Milkovich G
NEOMED College of Medicine
Ofloxacin – Administration and Dosage
Pneumonia – Drug Therapy
Random Assignment
Retrospective Design
T-Tests
Tennenberg AM
Xiang JX
Zadeikis N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4037/ajcc2015335" target="_blank" rel="noreferrer noopener">http://doi.org/10.4037/ajcc2015335</a>
Pages
440–445
Issue
5
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanical Ventilation Antioxidant Trial.
Publisher
An entity responsible for making the resource available
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-09
Subject
The topic of the resource
Adult; Female; Humans; Male; Middle Aged; Time Factors; Aged; Length of Stay; Treatment Outcome; Prospective Studies; Oxidative Stress; Double-Blind Method; Intensive Care Units; Antioxidants/*therapeutic use; Antioxidants; Oxidative Stress/*drug effects; Critical Care/*methods; Human; Chi Square Test; Funding Source; Data Analysis Software; Middle Age; T-Tests; Ascorbic Acid/therapeutic use; Critical Illness; Cystine/analogs & derivatives/therapeutic use; Inflammation/*drug therapy/*etiology; Vitamin E/therapeutic use; Vitamins/therapeutic use; 80 and over; Artificial; Respiration; Artificial/*adverse effects; Randomized Controlled Trials; Double-Blind Studies; Acetylcysteine; Critically Ill Patients; Dietary Supplementation; Log-Rank Test; Mantel-Haenszel Test; Ventilator Weaning; Vitamin E; 80 and Over; Ascorbic Acid – Administration and Dosage
Creator
An entity primarily responsible for making the resource
Howe Kimberly P; Clochesy John M; Goldstein Lawrence S; Owen Hugh
Description
An account of the resource
BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy and contractile dysfunction of diaphragmatic myofibers. Antioxidant supplementation might mitigate the harmful effects of the oxidative stress induced by mechanical ventilation. OBJECTIVE: To test the clinical effectiveness of antioxidant supplementation in reducing the duration of mechanical ventilation. METHODS: A randomized, prospective, placebo-controlled double-blind design was used to test whether enterally administered antioxidant supplementation would decrease the duration of mechanical ventilation, all-cause mortality, and length of stay in the intensive care unit and hospital. Patients received vitamin C 1000 mg plus vitamin E 1000 IU, vitamin C 1000 mg plus vitamin E 1000 IU plus N-acetylcysteine 400 mg, or placebo solution as a bolus injection via their enteral feeding tube every 8 hours. RESULTS: Clinical and statistically significant differences in duration of mechanical ventilation were seen among the 3 groups (Mantel-Cox log rank statistic = 5.69, df = 1, P = .017). The 3 groups did not differ significantly in all-cause mortality during hospitalization or in the length of stay in the intensive care unit or hospital. CONCLUSIONS: Enteral administration of antioxidants is a simple, safe, inexpensive, and effective intervention that decreases the duration of mechanical ventilation in critically ill adults.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4037/ajcc2015335" target="_blank" rel="noreferrer noopener">10.4037/ajcc2015335</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
80 and over
Acetylcysteine
Adult
Aged
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Antioxidants
Antioxidants/*therapeutic use
Artificial
Artificial/*adverse effects
Ascorbic Acid – Administration and Dosage
Ascorbic Acid/therapeutic use
Chi Square Test
Clochesy John M
Critical Care/*methods
Critical Illness
Critically Ill Patients
Cystine/analogs & derivatives/therapeutic use
Data Analysis Software
Department of Internal Medicine
Dietary Supplementation
Double-Blind Method
Double-Blind Studies
Female
Funding Source
Goldstein Lawrence S
Howe Kimberly P
Human
Humans
Inflammation/*drug therapy/*etiology
Intensive Care Units
Length of Stay
Log-Rank Test
Male
Mantel-Haenszel Test
Middle Age
Middle Aged
NEOMED College of Medicine
Owen Hugh
Oxidative Stress
Oxidative Stress/*drug effects
Prospective Studies
RANDOMIZED controlled trials
Respiration
T-Tests
Time Factors
Treatment Outcome
Ventilator Weaning
Vitamin E
Vitamin E/therapeutic use
Vitamins/therapeutic use