1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s10162-016-0601-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10162-016-0601-9</a>
Pages
343–353
Issue
2
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Long-Lasting forward Suppression of Spontaneous Firing in Auditory Neurons: Implication to the Residual Inhibition of Tinnitus.
Publisher
An entity responsible for making the resource available
Journal of the Association for Research in Otolaryngology : JARO
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
acoustic trauma; Animals; Brain Stem – Physiology; Clinical Assessment Tools; Cochlear Nerve – Physiology; Cochlear Nerve/*physiology; Inbred CBA; Inferior Colliculi/*physiology; inferior colliculus; Male; mice; Mice; residual inhibition; Sound; Tinnitus – Physiopathology; Tinnitus/*physiopathology
Creator
An entity primarily responsible for making the resource
Galazyuk A V; Voytenko S V; Longenecker R J
Description
An account of the resource
Tinnitus is the perception of a sound that has no external source. Sound stimuli can suppress spontaneous firing in auditory neurons long after stimulus offset. It is unknown how changes in sound stimulus parameters affect this forward suppression. Using in vivo extracellular recording in awake mice, we found that about 40 % of spontaneously active inferior colliculus (IC) neurons exhibited forward suppression of spontaneous activity after sound offset. The duration of this suppression increased with sound duration and lasted about 40 s following a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s10162-016-0601-9" target="_blank" rel="noreferrer noopener">10.1007/s10162-016-0601-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Acoustic trauma
Animals
Brain Stem – Physiology
Clinical Assessment Tools
Cochlear Nerve – Physiology
Cochlear Nerve/*physiology
Department of Anatomy & Neurobiology
Galazyuk A V
Inbred CBA
Inferior Colliculi/*physiology
inferior colliculus
Journal of the Association for Research in Otolaryngology : JARO
Longenecker R J
Male
Mice
NEOMED College of Medicine
residual inhibition
Sound
Tinnitus – Physiopathology
Tinnitus/*physiopathology
Voytenko S V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainres.2012.02.067" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2012.02.067</a>
Pages
54–62
Volume
1485
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
Acoustic Stimulation/instrumentation/*methods; Animal/physiology; Animals; Behavior; Habituation; Mice; Psychophysiologic/physiology; Reflex; Startle/*physiology; Tinnitus/*diagnosis/physiopathology
Creator
An entity primarily responsible for making the resource
Longenecker R J; Galazyuk A V
Description
An account of the resource
Recently prepulse inhibition of the acoustic startle reflex (ASR) became a popular technique for tinnitus assessment in laboratory animals. This method confers a significant advantage over the previously used time-consuming behavioral approaches utilizing basic mechanisms of conditioning. Although this technique has been successfully used to assess tinnitus in different laboratory animals, many of the finer details of this methodology have not been described enough to be replicated, but are critical for tinnitus assessment. Here we provide detail description of key procedures and methodological issues that provide guidance for newcomers with the process of learning to correctly apply gap detection techniques for tinnitus assessment in laboratory animals. The major categories of these issues include: refinement of hardware for best performance, optimization of stimulus parameters, behavioral considerations, and identification of optimal strategies for data analysis. This article is part of a Special Issue entitled: Tinnitus Neuroscience.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainres.2012.02.067" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2012.02.067</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Acoustic Stimulation/instrumentation/*methods
Animal/physiology
Animals
Behavior
Brain research
Department of Anatomy & Neurobiology
Galazyuk A V
Habituation
Longenecker R J
Mice
NEOMED College of Medicine
Psychophysiologic/physiology
Reflex
Startle/*physiology
Tinnitus/*diagnosis/physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2016.06.006</a>
Pages
80–93
Volume
339
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
*Audiometric functions; *Hearing loss; *Mouse; *Permanent threshold shift; *Sound exposure; *Temporary threshold shift; Acoustic Stimulation/*methods; Animal; Animals; Audiometry; Auditory; Auditory Threshold/*physiology; Brain Stem/*physiology; Evoked Potentials; Hearing; Inbred CBA; Male; Mice; Models; Noise; Prepulse Inhibition/*physiology; Pure-Tone/*methods; Reflex; Startle/*physiology
Creator
An entity primarily responsible for making the resource
Longenecker R J; Alghamdi F; Rosen M J; Galazyuk A V
Description
An account of the resource
The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for experimental manipulations targeting hearing loss in animal models. The standard auditory brainstem response (ABR) measurement is fairly quick and translational across species, but is limited by the need for anesthesia and a lack of perceptual assessment. The goal of this study was to develop a new method of hearing assessment utilizing prepulse inhibition (PPI) of the acoustic startle reflex, a commonly used tool that measures detection thresholds in awake animals, and can be performed on multiple animals simultaneously. We found that in control mice PPI audiometric functions are similar to both ABR and traditional operant conditioning audiograms. The hearing thresholds assessed with PPI audiometry in sound exposed mice were also similar to those detected by ABR thresholds one day after exposure. However, three months after exposure PPI threshold shifts were still evident at and near the frequency of exposure whereas ABR thresholds recovered to the pre-exposed level. In contrast, PPI audiometry and ABR wave one amplitudes detected similar losses. PPI audiometry provides a high throughput automated behavioral screening tool of hearing in awake animals. Overall, PPI audiometry and ABR assessments of the auditory system are robust techniques with distinct advantages and limitations, which when combined, can provide ample information about the functionality of the auditory system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2016.06.006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Audiometric functions
*Hearing loss
*Mouse
*Permanent threshold shift
*Sound exposure
*Temporary threshold shift
2016
Acoustic Stimulation/*methods
Alghamdi F
Animal
Animals
Audiometry
Auditory
Auditory Threshold/*physiology
Brain Stem/*physiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk A V
Hearing
Hearing research
Inbred CBA
Longenecker R J
Male
Mice
Models
NEOMED College of Medicine
Noise
Prepulse Inhibition/*physiology
Pure-Tone/*methods
Reflex
Rosen M J
Startle/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2019.01.022" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2019.01.022</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-13
Volume
375
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology; NEOMED Postdoc Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Residual inhibition: From the putative mechanisms to potential tinnitus treatment.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-04
Creator
An entity primarily responsible for making the resource
Galazyuk A V; Longenecker R J; Voytenko S V; Kristaponyte I; Nelson G L
Description
An account of the resource
Neurons in various sensory systems show some level of spontaneous firing in the absence of sensory stimuli. In the auditory system spontaneous firing has been shown at all levels of the auditory pathway from spiral ganglion neurons in the cochlea to neurons of the auditory cortex. This internal "noise" is normal for the system and it does not interfere with our ability to perceive silence or analyze sound. However, this internal noise can be elevated under pathological conditions, leading to the perception of a phantom sound known as tinnitus. The efforts of many research groups, including our own, led to the development of a mechanistic understanding of this process: After cochlear insult the input to the central auditory system becomes markedly reduced. As a result, the neural activity in the central auditory system is enhanced to compensate for this reduced input. Such hyperactivity is hypothesized to be interpreted by the brain as a presence of sound. This implies that suppression of hyperactivity should reduce/eliminate tinnitus. This review explores research from our laboratory devoted to identifying the mechanism underlying residual inhibition of tinnitus, a brief suppression of tinnitus following a sound stimulus. The key mechanisms that govern neural suppression of spontaneous activity in animals closely resemble clinical psychoacoustic findings of residual inhibition (RI) observed in tinnitus patients. This suppression is mediated by metabotropic glutamate receptors (mGluRs). Lastly, drugs targeting mGluRs suppress spontaneous activity in auditory neurons and reduce/eliminate behavioral signs of tinnitus in mice. Thus, these drugs are therapeutically relevant for tinnitus suppression in humans.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2019.01.022" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2019.01.022</a>
2019
Department of Anatomy & Neurobiology
Galazyuk A V
Hearing research
Kristaponyte I
Longenecker R J
Nelson G L
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
Voytenko S V