Browse Items · NEOMED Bibliography Database

Synaptic Inhibition in Avian Interaural Level Difference Sound Localizing Neurons.

Synaptic inhibition plays a fundamental role in the neural computation of the interaural level difference (ILD), an important cue for the localization of high-frequency sound. Here, we studied the inhibitory synaptic currents in the chicken posterior…

Tags: *dorsal nucleus of the lateral lemniscus, *GABAA receptor, *interaural level difference, *reversal potential, *synaptic inhibition, 2016, Acoustic Stimulation/methods, Animals, Anions/metabolism, Avian Proteins/metabolism, Brain Stem/cytology/drug effects/*physiology, Chick Embryo, Chlorides/metabolism, Curry Rebecca J, Department of Anatomy & Neurobiology, Electric Stimulation, eNeuro, Female, GABA-A/metabolism, gamma-Aminobutyric Acid/metabolism, Glycine/metabolism, Intracellular Space/drug effects/metabolism, Lu Yong, Male, NEOMED College of Medicine, Neural Inhibition/drug effects/*physiology, Neurons/cytology/drug effects/*physiology, Patch-Clamp Techniques, Receptors, Sound Localization/drug effects/*physiology, Symporters/metabolism, Synaptic Transmission/drug effects/*physiology, Tissue Culture Techniques

Neurotransmitter- and Release-Mode-Specific Modulation of Inhibitory Transmission by Group I Metabotropic Glutamate Receptors in Central Auditory Neurons of the Mouse.

Neuromodulation mediated by metabotropic glutamate receptors (mGluRs) regulates many brain functions. However, the functions of mGluRs in the auditory system under normal and diseased states are not well understood. The medial nucleus of the…

Tags: 2018, Curry Rebecca J, Department of Anatomy & Neurobiology, GABA, glycine, IPSC, Lu Yong, mGluR, MNTB, NEOMED College of Medicine, neuromodulation, Peng Kang, The Journal of neuroscience : the official journal of the Society for Neuroscience

Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.

Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between…

Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.

GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic…

Tags: 2-Amino-5-phosphonovalerate/pharmacology, 2007, Amino Acids/pharmacology, Animals, Chickens/*physiology, Cochlear Nucleus/*cytology/*physiology, Department of Anatomy & Neurobiology, Electric Stimulation, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/physiology, GABA-B Receptor Agonists, GABA-B Receptor Antagonists, GABA-B/physiology, gamma-Aminobutyric Acid/*physiology, Glycine/analogs & derivatives/pharmacology, In Vitro Techniques, Journal of neurophysiology, Kinetics, Lu Yong, Membrane Potentials/drug effects, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology, Models, NEOMED College of Medicine, Neurological, Neurons/*physiology, Patch-Clamp Techniques, Receptors, Resorcinols/pharmacology, Synapses/physiology, Synaptic Transmission/*physiology, Xanthenes/pharmacology

Subtle differences in synaptic transmission in medial nucleus of trapezoid body neurons between wild-type and Fmr1 knockout mice

In animal models for fragile X syndrome where the gene for fragile X mental retardation protein is knocked out (Fmr1 KO), neurotransmission in multiple brain regions shifts excitation/inhibition balance, resulting in hyperexcitability in neural…

Tags: 2019, Brain research, Department of Anatomy & Neurobiology, Fragile X syndrome, June 2019 Update, Lu Yong, MNTB, NEOMED College of Medicine, Synaptic excitation, synaptic inhibition

Activity-dependent synaptic integration and modulation of bilateral excitatory inputs in an auditory coincidence detection circuit.

KEY POINTS: Binaural excitatory inputs to coincidence detection neurons in nucleus laminaris (NL) play essential roles in interaural time difference coding for sound localization. Here, we show that the two excitatory inputs are physiologically…

Tags: 2018, Curry Rebecca J, Department of Anatomy & Neurobiology, EPSC, Liu Yu-Wei, Lu Yong, mGluR, NEOMED College of Medicine, neuromodulation, synaptic integration, The Journal of physiology

Mechanisms underlying auditory processing deficits in Fragile X syndrome.

Autism spectrum disorders (ASD) are strongly associated with auditory hypersensitivity or hyperacusis (difficulty tolerating sounds). Fragile X syndrome (FXS), the most common monogenetic cause of ASD, has emerged as a powerful gateway for exploring…

Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons.

Neurons in the avian cochlear nucleus angularis (NA) receive glutamatergic input from the auditory nerve, and GABAergic input from the superior olivary nucleus. Physiologically heterogeneous, NA neurons perform multiple functions including encoding…

Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.

Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in…

Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.

Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus…

Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.

Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at…

Tags: 2013, Amino Acids/pharmacology, Animals, Chick Embryo, Cochlear Nucleus/drug effects/metabolism, Curry Rebecca J, Cyclopropanes/pharmacology, Department of Anatomy & Neurobiology, Dinh Emilie Hoang, Excitatory Amino Acid Agonists/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects/physiology, GABAergic Neurons/drug effects/*metabolism, Glycine/analogs & derivatives/pharmacology, Hamlet William R, Inhibitory Postsynaptic Potentials/drug effects/physiology, Liu Yu-Wei, Long-Term Synaptic Depression/drug effects/*physiology, Lu Yong, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism, NEOMED College of Medicine, Neural Inhibition/drug effects/physiology, Receptors, Shi Wei, Synapses/drug effects/*metabolism, Synaptic Transmission/drug effects/*physiology, Tang Zheng-Quan, The Journal of neuroscience : the official journal of the Society for Neuroscience, Xanthenes/pharmacology

Two GABAA responses with distinct kinetics in a sound localization circuit.

The temporal characteristics and functional diversity of GABAergic inhibition are determined by the spatiotemporal neurotransmitter profile, intrinsic properties of GABAA receptors, and other factors. Here, we report two distinct GABAA responses and…

Tags: *Sound, 2012, Animals, Chick Embryo, Chickens, Department of Anatomy & Neurobiology, Female, GABA-A/*physiology, gamma-Aminobutyric Acid/metabolism, Lu Yong, Male, NEOMED College of Medicine, Neurons/*metabolism, Pitch Discrimination, Receptors, Sound Localization/*physiology, Synapses/physiology, Tang Zheng-Quan, The Journal of physiology

Development of GPCR modulation of GABAergic transmission in chicken nucleus laminaris neurons.

Neurons in the nucleus laminaris (NL) of birds act as coincidence detectors and encode interaural time difference to localize the sound source in the azimuth plane. GABAergic transmission in a number of CNS nuclei including the NL is subject to a…

Tags: *Synaptic Transmission, 2012, Animals, Brain/*cytology, Chickens/*metabolism, Department of Anatomy & Neurobiology, G-Protein-Coupled/*metabolism, GABA-A/metabolism, GABA-B/metabolism, gamma-Aminobutyric Acid/*metabolism, Lu Yong, Metabotropic Glutamate/metabolism, NEOMED College of Medicine, Neurons/*metabolism, Patch-Clamp Techniques, PloS one, Receptors, Synapses/metabolism, Tang Zheng-Quan

Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.

Neurons of the avian cochlear nucleus magnocellularis (NM) receive glutamatergic inputs from the spiral ganglion cells via the auditory nerve and feedback GABAergic inputs primarily from the superior olivary nucleus. We investigated regulation of…

Postsynaptic FMRP Regulates Synaptogenesis In Vivo in the Developing Cochlear Nucleus.

A global loss of the fragile X mental retardation protein (FMRP; encoded by the Fmr1 gene) leads to sensory dysfunction and intellectual disabilities. One underlying mechanism of these phenotypes is structural and functional deficits in synapses.…

Tags: 2018, auditory processing, dendritic maturation, Department of Anatomy & Neurobiology, endbulb synapse, fragile X mental retardation protein, Lu Yong, NEOMED College of Medicine, Schecterson Leslayann, The Journal of neuroscience : the official journal of the Society for Neuroscience, trans-synaptic regulation, Wang Xiaoyu, Wang Yuan, Zorio Diego A R

Browse Items (15 total)