1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1993.74.6.3068" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1993.74.6.3068</a>
Pages
3068–3072
Issue
6
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of peak inspiratory pressure on the filtration coefficient in the isolated perfused rat lung.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-06
Subject
The topic of the resource
Animals; Biological; Body Fluids/physiology; Capillary Permeability; Evaluation Studies as Topic; In Vitro Techniques; Lung/blood supply/*physiology; Male; Models; Perfusion; Positive-Pressure Respiration; Pressure; Rats; Respiration/physiology; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Omlor G; Niehaus G D; Maron M B
Description
An account of the resource
Positive inspiratory pressure- (PIP) ventilated, isolated rat lungs become edematous when perfused at rates approximately the normal cardiac output. The study was conducted to test the hypothesis that high peak inspiratory pressures contribute to the edema development. Five isolated lungs were perfused at a rate of 24.4 +/- 2.2 ml.min-1.100 g body wt-1 with 40% whole blood (diluted with saline containing 4.0 g/100 ml bovine serum albumin) and ventilated with peak pressures ranging from 0 to 20 mmHg. The lungs exhibited edema at PIP values \textgreater 9.3 mmHg. The stable pulmonary vascular pressure and resistance suggested that the edema may have resulted from a PIP-induced increase in microvascular permeability. In a second study, the stability of the preparation was evaluated during a 3-h test period. Seven lungs were ventilated at a peak inspiratory pressure of 8.0 mmHg and perfused at 26.8 +- 1.7 ml.min-1 x 100 g body wt-1. Microvascular integrity was maintained for approximately 2 h as indicated by filtration coefficient measurements of 0.175 +/- 0.068, 0.197 +/- 0.066, and 0.169 +/- 0.067 g.min-1 x mmHg-1 x 100 g-1 at 25, 70, and 115 min, respectively, after initiation of the study. The results suggest that isolated rat lungs perfused at rates that parallel normal rat cardiac output and ventilated at low peak inspiratory pressures provide a viable mechanism for evaluation of the pathophysiology of microvascular injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1993.74.6.3068" target="_blank" rel="noreferrer noopener">10.1152/jappl.1993.74.6.3068</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Biological
Body Fluids/physiology
Capillary Permeability
Department of Integrative Medical Sciences
Evaluation Studies as Topic
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Lung/blood supply/*physiology
Male
Maron M B
Models
NEOMED College of Medicine
Niehaus G D
Omlor G
Perfusion
Positive-Pressure Respiration
Pressure
Rats
Respiration/physiology
Sprague-Dawley