Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review.
Adult; Humans; Male; Antifungal Agents/therapeutic use; Itraconazole/therapeutic use; Ketoconazole/therapeutic use; Hypergammaglobulinemia/*complications; Thymoma/*complications; Thymus Neoplasms/*complications; Candidiasis; Lupus Erythematosus; Chronic Mucocutaneous/*complications/drug therapy; Systemic/*complications
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent candidal infections of the mucous membranes, nails, and skin. Systemic involvement is rare. CMC in adults with coexistent thymoma, benign or malignant, is well-known and is often associated with hypogammaglobulinemia. There is an unusually high frequency of thymoma and systemic lupus erythematosus (SLE). I present a case of a patient with a history of malignant thymoma, SLE, and hypergammaglobulinemia who was found to have CMC. Discussion of the relationship of these findings is presented.
San Filippo James
Cutis
2006
2006-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Drug-induced lupus. The list of culprits grows.
Humans; Male; Aged; Quinidine/*adverse effects; Lupus Erythematosus; Systemic/*chemically induced
More than 70 medications have been implicated as a cause of drug-induced lupus. The condition most commonly manifests with arthralgias and fever. The most important laboratory feature is an elevated antinuclear antibody titer, which often corresponds to the presence of antihistone antibodies. Fortunately, the course of drug-induced lupus is more benign than that of idiopathic systemic lupus erythematosus. Clinical resolution generally occurs after withdrawal of the offending agent. The patient described here exemplifies the importance of maintaining a heightened awareness of this uncommon disorder. For him, delayed diagnosis of drug-induced lupus resulted in prolonged discomfort, restriction of daily activities, and unnecessary therapeutic intervention.
Rich M W
Postgraduate medicine
1996
1996-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3810/pgm.1996.09.83" target="_blank" rel="noreferrer noopener">10.3810/pgm.1996.09.83</a>
Serine Proteases in Systemic Lupus Erythematosus: The Other Half of the Story.
Female; Humans; Immunity; Mannose-Binding Lectin/*metabolism; Mannose-Binding Protein-Associated Serine Proteases/*metabolism; Lupus Erythematosus; Innate/*immunology; Systemic/*immunology/*physiopathology; Proteins – Metabolism; Immunity – Immunology; Systemic – Immunology; Systemic – Physiopathology
Rothschild Bruce
The Journal of rheumatology
2016
2016-01
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3899/jrheum.150726" target="_blank" rel="noreferrer noopener">10.3899/jrheum.150726</a>
The contribution of interleukin-2 to effective wound healing.
*cutaneous diseases; *cytokines; *immunotherapy; *Interleukin-2; *therapeutic targets; *wound healing; Animals; Cell Differentiation/physiology; Cell Proliferation/physiology; Diabetes Mellitus/metabolism/pathology; Humans; Interleukin-2/*metabolism; Interleukin-2/*metabolism/*therapeutic use; Lupus Erythematosus; Mice; Myocardial Infarction/metabolism/pathology; Receptors; Sarcoidosis/metabolism/pathology; Signal Transduction/physiology; Skin/*injuries; Systemic/metabolism/pathology; T-Lymphocytes/cytology/immunology; Wound Healing/*physiology
Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment. When these interactions are perturbed, wounds can be a nidus for infection, which can cause them to remain open an extended period of time, or can scar excessively. Interleukin-2, a cytokine that directs T-cell expansion and phenotypic development, appears to play an important role in wound healing. The best-studied role for Interleukin-2 is in influencing
Doersch Karen M; DelloStritto Daniel J; Newell-Rogers M Karen
Experimental biology and medicine (Maywood, N.J.)
2017
2017-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1177/1535370216675773" target="_blank" rel="noreferrer noopener">10.1177/1535370216675773</a>