1
40
4
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofz360.577" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofz360.577</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S246-S246
Volume
6
ISSN
23288957
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ofid/ofz360.577" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ofid/ofz360.577</a>
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
508. Gentamicin Non-susceptibility is Associated with Persistence of Carbapenem-Resistant Klebsiella pneumoniae in the Urinary Tract.
Publisher
An entity responsible for making the resource available
Open Forum Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-10-02
Subject
The topic of the resource
NORTH Carolina; hospital admission; bacteriuria; urine; laboratory; antimicrobial susceptibility; Klebsiella pneumonia; bacteriuria; CENTERS for Disease Control & Prevention (U.S.); urinary tract infections; URINARY organs; urinary tract; health care systems; disclosure; CENTERS for Disease Control & Prevention (U.S.); amikacin; antibiotic overuse; carbapenem resistance; carbapenem-resistant enterobacteriaceae; GENTAMICIN; gentamicin sulfate (usp); gentamicins; health care safety; Klebsiella pneumonia; midwestern united states; persistence; persistence; rales; signs and symptoms; trimethoprim-sulfamethoxazole combination; urinary tract infections; urine culture
Creator
An entity primarily responsible for making the resource
Luterbach Courtney L; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kaye Keith S; Doi Yohei; Watkins Richard R; Bonomo Robert A; Duin David van
Description
An account of the resource
Background Urinary tract infection (UTI) is the most common clinical manifestation of carbapenem-resistant Klebsiella pneumoniae (CR Kp). Persistent CR Kp bacteriuria is associated with the spread of CR Kp and antibiotic overuse. Risk factors for persistent CR Kp bacteriuria are uncertain. Methods CRACKLE-1 was a multicenter, prospective study that included 960 patients with at least one carbapenem-resistant Enterobacteriaceae (CRE)-positive culture from December 2011 to June 2016 collected from 18 hospitals encompassing 8 healthcare systems in the Midwestern US and North Carolina. Patients with CR Kp bacteriuria who were discharged alive from index hospitalization were included in the current study, and sporadic (single positive CR Kp urine culture) and persistent (≥2 CR Kp urine cultures during independent hospital admissions occurring at least 2 days apart) cases were compared. Antibiotic susceptibility testing was performed by local laboratories. Amikacin, gentamicin (GENT), and trimethoprim/sulfamethoxazole were included in the analysis based on variance and frequency of testing. The CDC/National Healthcare Safety Network criteria for UTI were used. Results CR Kp was the most common CRE isolate (n = 869, prevalence 91%). In patients with CR Kp , 527 had CR Kp isolated from the urine (prevalence 61%, 95% CI 0.57, 0.64). Of these, 486 patients, of whom 129 (27%) were diagnosed with a UTI, were discharged alive. Notably, 135/486 (28%) patients with CR Kp bacteriuria were readmitted and yielded a second urine culture of CR Kp. Most patients with persistent bacteriuria, 99/135 (73%), were asymptomatic at initial admission. Of these patients, 20/99 (20%) were diagnosed with a UTI at second admission. In multivariable analysis, only GENT non-susceptibility was associated with an increased risk (adjusted OR 1.66, 95% CI 1.10–2.49) of persistent bacteriuria. Persistent bacteriuria was independent of GENT treatment during index hospitalization (GENT was used in 15% of patients). Conclusion Bacteriuria with GENT non-susceptible CR Kp strains was associated with persistent bacteriuria. As this was independent of GENT treatment, GENT resistance determinants may be co-transmitted along with traits that promote bacterial persistence in CR Kp. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofz360.577" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofz360.577</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
amikacin
antibiotic overuse
antimicrobial susceptibility
bacteriuria
Bonomo Robert A
carbapenem resistance
carbapenem-resistant Enterobacteriaceae
CENTERS for Disease Control & Prevention (U.S.)
Cleveland Clinic Akron General Hospital
Cober Eric
Department of Internal Medicine
Disclosure
Doi Yohei
Duin David van
Gentamicin
gentamicin sulfate (usp)
gentamicins
health care safety
health care systems
Henderson Heather I
hospital admission
Journal Article
Kaye Keith S
Klebsiella pneumonia
Laboratory
Luterbach Courtney L
Midwestern United States
NEOMED College of Medicine
North Carolina
November 2019 Update
Open forum infectious diseases
Persistence
rales
Richter Sandra S
Salata Robert A
signs and symptoms
Trimethoprim-Sulfamethoxazole Combination
URINARY organs
urinary tract
Urinary Tract Infections
Urine
urine culture
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
N.PAG-N.PAG
Issue
1
Volume
6
ISSN
23288957
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ofid/ofy351</a>
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open Forum Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
antimicrobial resistance; carbapenem-resistant enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
An entity primarily responsible for making the resource
Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Duin David van
Description
An account of the resource
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Clev eland Clinic Akron General Hosptial
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Duin David van
Evans Scott
Fowler Vance G
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Journal Article
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
November 2019 Update
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciz528" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciz528</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Pitt Bacteremia Score Predicts Mortality in Non-Bacteremic Infections.
Publisher
An entity responsible for making the resource available
Clinical Infectious Diseases: An Official Publication Of The Infectious Diseases Society Of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Creator
An entity primarily responsible for making the resource
Henderson Heather; Luterbach Courtney L; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Harris Anthony; Napravnik Sonia; van Duin David
Description
An account of the resource
Background: Predicting mortality risk in patients is important in research settings. The Pitt bacteremia score (PBS) is commonly used as a predictor of early mortality risk in patients with bloodstream infections (BSI). Here, we determined whether the PBS predicts 14-day inpatient mortality in non-bacteremia carbapenem-resistant Enterobacteriaceae (CRE) infections.; Methods: Patients were selected from the Consortium on resistance against carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE-1), a prospective, multicenter, observational study. We estimated risk ratios to analyze the predictive ability of the PBS overall and each of its components individually. We analyzed each component of the PBS in the prediction of mortality, assessed the appropriate cutoff value for the dichotomized score, and compared the predictive ability of the qPitt score to that of the PBS.; Results: In a cohort of 475 patients with CRE infections, a PBS ≥ 4 was associated with mortality in patients with non-bacteremia infections (RR=21.9 [95% CI: 7.0, 68.8]) and with BSI (RR=6.0 [95% CI: 2.5, 14.4]). In multivariable analysis, the hypotension, mechanical ventilation, mental status, and cardiac arrest parameters of the PBS were independent risk factors for 14-day all-cause inpatient mortality. The temperature parameter as originally calculated for the PBS was not independently associated with mortality. However, a temperature < 36.0ᴼ C versus ≥ 36ᴼ C was independently associated with mortality. A qPitt score ≥ 2 had similar discrimination as a PBS ≥ 4 in non-bacteremia infections.; Conclusion: Here, we validated that the PBS and qPitt score can be used as reliable predictors of mortality in non-bacteremia CRE infections.; © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/cid/ciz528" target="_blank" rel="noreferrer noopener">10.1093/cid/ciz528</a>
2019
Bonomo Robert A
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Cober Eric
Department of Family & Community Medicine
Department of Internal Medicine
Doi Yohei
Evans Scott
Fowler Vance G
Harris Anthony
Henderson Heather
Kalayjian Robert C
Kaye Keith S
Luterbach Courtney L
Napravnik Sonia
NEOMED College of Medicine
Richter Sandra S
Salata Robert A
September 2019 Update
van Duin David
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
Pages
ofy351–ofy351
Issue
1
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
An entity responsible for making the resource available
Open forum infectious diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
antimicrobial resistance; carbapenem-resistant Enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
An entity primarily responsible for making the resource
Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G Jr; Bonomo Robert A; van Duin David
Description
An account of the resource
In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Evans Scott
Fowler Vance G Jr
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
van Duin David
Watkins Richard R