1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1152/ajpheart.1990.258.3.H748" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1990.258.3.H748</a> Pages H748–753 Issue 3 Volume 258 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Macromolecular transport in canine coronary microvasculature. Publisher An entity responsible for making the resource available The American journal of physiology Date A point or period of time associated with an event in the lifecycle of the resource 1990 1990-03 Subject The topic of the resource *Coronary Circulation; Animals; Biological Transport; Blood Proteins/metabolism; Coronary Disease/metabolism; Dogs; Female; Immunoglobulin G/*metabolism; Immunoglobulin M/*metabolism; Lymph/metabolism; Macromolecular Substances; Male; Microcirculation; Myocardial Reperfusion; Myocardium/metabolism; Osmolar Concentration; Permeability; Reference Values; Serum Albumin/*metabolism Creator An entity primarily responsible for making the resource Pilati C F Description An account of the resource Coronary vascular osmotic reflection coefficients (sigma dS) for total protein, albumin (Alb), immunoglobulin (Ig)G, and IgM were determined in the anesthetized dog. Myocardial lymph was collected from the anterior interventricular lymphatic trunk, and the sigma dS estimated from filtration rate-independent lymph-to-plasma protein concentration ratios (CL/CPS). Lymph flows of at least 12 times base line were needed to produce filtration rate-independent CL/CPS, and these were achieved in 9 of 12 experiments. In these nine experiments, sigma dS for total protein, Alb, IgG, and IgM were, respectively, 0.67 +/- 0.02 (SE), 0.59 +/- 0.05, 0.70 +/- 0.03, and 0.87 +/- 0.01. The data were fitted to a model that showed that transvascular fluid and solute flux could be described by two populations of pores. A large pore system with an equivalent radius of 235 A was responsible for 39% of the transvascular volume flow. A small pore system less than 53 A accounted for the remaining flow. In a second group of experiments (n = 8), 60 min of ischemia decreased the sigma dS to 0.27 +/- 0.03, 0.07 +/- 0.05, 0.22 +/- 0.03, and 0.69 +/- 0.04 for total protein, Alb, IgG, and IgM, respectively. A single population of pores of 220 A could describe the entire transvascular volume flow. These results indicate that coronary vascular protein permeability is moderately high and can be increased significantly by ischemia. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1152/ajpheart.1990.258.3.H748" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1990.258.3.H748</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Coronary Circulation 1990 Animals Biological Transport Blood Proteins/metabolism Coronary Disease/metabolism Dogs Female Immunoglobulin G/*metabolism Immunoglobulin M/*metabolism Lymph/metabolism Macromolecular Substances Male Microcirculation Myocardial Reperfusion Myocardium/metabolism Osmolar Concentration Permeability Pilati C F Reference Values Serum Albumin/*metabolism The American journal of physiology