A computer model for the study of breast cancer.
*Computer Simulation; Breast Neoplasms/epidemiology/mortality/*pathology; Female; Humans; Incidence; Life Expectancy; Lymphatic Metastasis; Neoplasm Metastasis; SEER Program; Software; United States/epidemiology
A computer model was designed as a relational database to assess breast cancer screening in a cohort of women where the growth and development of breast cancer originates with the first malignant cell. The concepts of thresholds for growth, axillary spread, and distant sites are integrated. With tumor diagnosis, staging was performed that includes clinical and sub-clinical states. The model was parameterized to have staging characteristics similar to data published by the Surveillance, Epidemiology, and End-Results (SEER) Program. Validation was accomplished by comparing simulated staging results with non-SEER sources, and simulated survival with independent clinical survival data.
Carter Kimbroe J; Castro Frank; Kessler Edward; Erickson Barbara
Computers in biology and medicine
2003
2003-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/s0010-4825(03)00003-9" target="_blank" rel="noreferrer noopener">10.1016/s0010-4825(03)00003-9</a>
Breast cancer screening in a private women's clinic.
Adult; Female; Humans; Middle Aged; Ohio; Biopsy; Hospitals; Lymphatic Metastasis; Costs and Cost Analysis; *Mass Screening/economics; Breast Neoplasms/economics/*epidemiology; Breast/pathology; Mammography/economics; Needle/economics; Proprietary
A review of 6109 mammograms representing 4332 patients seen over 4 years is presented. The American Cancer Society guidelines for mammography screening were followed. Forty-five percent of all tumors were nonpalpable; in 12% of these the lymph nodes were positive for cancer. In the group with palpable breast cancers, 62% had positive lymph nodes. Screening mammography results in an increased number of localization biopsies. Biopsy rates were compared with several series. Costs for mammography screening programs were reviewed and related to the cost of each breast cancer detected. In our series the cost per cancer detected was $13,000. This study provides evidence to justify the American Cancer Society guidelines.
Tifft J G; Jarjoura D
American journal of obstetrics and gynecology
1988
1988-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0002-9378(88)90374-2" target="_blank" rel="noreferrer noopener">10.1016/0002-9378(88)90374-2</a>
Selective lateral compartment neck dissection for thyroid cancer.
80 and over; Adenocarcinoma; Adult; Aged; Carcinoma; Female; Follicular/mortality/secondary/surgery; Follow-Up Studies; Humans; Local/mortality/pathology/surgery; Lymph Node Excision/*methods; Lymph Nodes/anatomy & histology/surgery; Lymphatic Metastasis; Male; Medullary/mortality/secondary/*surgery; Middle Aged; Morbidity; Neck Dissection/*methods; Neck Muscles/anatomy & histology/surgery; Neoplasm Recurrence; Papillary/mortality/secondary/surgery; Retrospective Studies; Selective lateral compartment neck dissection; Thyroid cancer; Thyroid Neoplasms/mortality/pathology/*surgery; Thyroidectomy/*methods; Young Adult
BACKGROUND: Compartment-oriented lymph node dissection in patients with thyroid cancer and macroscopic lymph node metastases reduces recurrence and improves survival. However, the extent of lymph node dissection remains controversial. The purpose of this study was to examine the results of selective lateral compartment neck dissection (LCND) for thyroid cancer. METHODS: We completed a retrospective review of patients with thyroid cancer who underwent selective LCND from
Welch Kellen; McHenry Christopher R
The Journal of surgical research
2013
2013-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.jss.2013.04.084" target="_blank" rel="noreferrer noopener">10.1016/j.jss.2013.04.084</a>
The importance of extranodal extension in penile cancer: a meta-analysis.
Comparative Studies; Cox Proportional Hazards Model; Evaluation Research; Human; Humans; Lymph Nodes – Pathology; Lymph Nodes/pathology; Lymphatic Metastasis; Male; Meta Analysis; Multicenter Studies; Neoplasm Metastasis; Odds Ratio; Penile Neoplasms – Diagnosis; Penile Neoplasms – Mortality; Penile Neoplasms – Pathology; Penile Neoplasms/diagnosis/*mortality/*pathology; Prognosis; Proportional Hazards Models; Publication Bias; Validation Studies
BACKGROUND: The role of extranodal extension (ENE) in penile cancer is controversial and has not been well studied. The aim of this study was to investigate the importance of ENE in predicting prognosis and presence of pelvic lymph node metastasis (PLNM) in penile cancer patients. METHODS: We searched related studies in Medline, Embase, Cochrane Library, and Scopus database. Hazard ratio (HR) and odds ratio (OR) were directly extracted or indirectly estimated from the included studies. RESULTS: A total of ten studies with 1,142 patients were included in this meta-analysis. Patients with ENE showed a worse cancer-specific survival (CSS) (HR = 1.90, 95 % confidence interval [CI] = 1.35-2.67, P = 0.0002) and overall survival (HR = 4.04, 95 % CI = 1.02-16.1, P = 0.05) than those without ENE. Further subgroup analysis revealed that the predictive value of ENE for CSS in penile cancer patients was significant regardless of the study's country of origin, but not in the subgroup with shorter follow-up time (\textless36 months, P = 0.38). Patients with ENE also showed a higher incidence of presenting with PLNM (OR = 4.95, 95 % CI = 2.58-9.49, P \textless 0.001). A stratified analysis demonstrated that the predictive role of ENE for PLNM was only detected in studies with a larger sample size (\textgreater 100 cases). No significant publication bias was observed, as suggested by Begg's and Egger's tests. CONCLUSIONS: ENE is associated with worse prognosis and high risk of PLNM in penile cancer patients. Due to the limited number of studies included in this meta-analysis, a large-scale, well-designed study will be required to verify our results.
Zhang Zhi-Ling; Yu Chun-Ping; Liu Zhuo-Wei; Velet Liliya; Li Yong-Hong; Jiang Li-Juan; Zhou Fang-Jian
BMC cancer
2015
2015-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1186/s12885-015-1834-4" target="_blank" rel="noreferrer noopener">10.1186/s12885-015-1834-4</a>